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Information on EC 2.7.11.22 - cyclin-dependent kinase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P17157

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IUBMB Comments
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
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Saccharomyces cerevisiae
UNIPROT: P17157
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Word Map
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
cyclin-dependent kinase, cdk, p34cdc2, cdkl5, cdc2 kinase, cyclin-dependent kinase 5, cyclin-dependent kinase 2, cdc28, cyclin-dependent kinase 4, cyclin-dependent kinase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
negative regulator of the PHO system
-
B-type cyclin-dependent kinase
-
-
Cdc28p-Chlp kinase
-
-
cell division control protein 28
-
CTD kinase alpha subunit
-
cyclin-dependent kinase
-
-
Cyclin-dependent kinase pef1
-
-
-
-
G1/S cyclin-dependent kinase
-
-
meiosis induction protein kinase IME2/SME1
-
meiotic mRNA stability protein kinase UME5
-
PHO85
PHO85 homolog
-
-
-
-
phosphate-activated cyclin-dependent kinase
-
-
phosphate-sensing CDK
-
-
serine/threonine protein kinase SGV1
-
serine/threonine-protein kinase CAK1
-
serine/threonine-protein kinase KIN28
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:cyclin phosphotransferase
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
CAS REGISTRY NUMBER
COMMENTARY hide
150428-23-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + Gcn4 protein
ADP + phosphorylated Gcn4 protein
show the reaction diagram
-
-
-
?
ATP + Glc8 protein
ADP + phosphorylated Glc8 protein
show the reaction diagram
-
-
-
?
ATP + Gsy2 protein
ADP + phosphorylated Gsy2 protein
show the reaction diagram
-
-
-
?
ATP + Pho4 protein
ADP + phosphorylated Pho4 protein
show the reaction diagram
-
-
-
?
ATP + Rga2 protein
ADP + phosphorylated Rga2 protein
show the reaction diagram
-
-
-
?
ATP + Rim 15 protein
ADP + phosphorylated Rim15 protein
show the reaction diagram
-
-
-
?
ATP + Rvs167 protein
ADP + phosphorylated Rvs167 protein
show the reaction diagram
-
-
-
?
ATP + Sic1 protein
ADP + phosphorylated Sic1 protein
show the reaction diagram
-
-
-
?
ATP + Whi5 G1 protein
ADP + phosphorylated Whi5 G1 protein
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + ADAQHATPPKKKRKVEDPKDF
ADP + ADAQHAT(P)PPKKKRKVEDPKDF
show the reaction diagram
-
a histone peptide substrate
-
-
?
ATP + Bni4
ADP + phosphorylated Bni4
show the reaction diagram
-
-
-
-
?
ATP + Boi1
ADP + phosphorylated Boi1
show the reaction diagram
-
-
-
-
?
ATP + Boi2
ADP + phosphorylated Boi2
show the reaction diagram
-
-
-
-
?
ATP + Cdc6
ADP + phosphorylated Cdc6
show the reaction diagram
-
-
-
-
?
ATP + Clb6
ADP + phosphorylated Clb6
show the reaction diagram
-
-
-
-
?
ATP + Cln3 protein
ADP + Cln3 phosphoprotein
show the reaction diagram
-
recombinant His-tagged Cln3 protein is phosphorylated by Pho85/Pho80 complexes at S449 and T520. Cdc28 phosphorylates Cln3 to a greater extent than Pho85, probably because it phosphorylates Cln3 at more sites in the PEST region than Pho85
-
-
?
ATP + cyclin-dependent kinase
ADP + phosphorylated cyclin-dependent kinase
show the reaction diagram
-
-
-
?
ATP + Fin1
ADP + phosphorylated Fin1
show the reaction diagram
-
-
-
-
?
ATP + Fkh2p
ADP + phosphorylated Fkh2p
show the reaction diagram
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 2
ADP + phosphorylated mini-chromosomemaintenance protein 2
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 3
ADP + phosphorylated mini-chromosomemaintenance protein 3
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 4
ADP + phosphorylated mini-chromosomemaintenance protein 4
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 5
ADP + phosphorylated mini-chromosomemaintenance protein 5
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 6
ADP + phosphorylated mini-chromosomemaintenance protein 6
show the reaction diagram
-
-
-
-
?
ATP + mini-chromosomemaintenance protein 7
ADP + phosphorylated mini-chromosomemaintenance protein 7
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 1
ADP + phosphorylated origin recognition complex 1
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 2
ADP + phosphorylated origin recognition complex 2
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 3
ADP + phosphorylated origin recognition complex 3
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 4
ADP + phosphorylated origin recognition complex 4
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 5
ADP + phosphorylated origin recognition complex 5
show the reaction diagram
-
-
-
-
?
ATP + origin recognition complex 6
ADP + phosphorylated origin recognition complex 6
show the reaction diagram
-
-
-
-
?
ATP + Pho81
ADP + phosphorylated Pho81
show the reaction diagram
-
-
phosphorylated Pho81 is an inhibitor for Pho85
-
?
ATP + Rad9 protein
ADP + Rad9 phosphoprotein
show the reaction diagram
ATP + Rga2
ADP + phosphorylated Rga2
show the reaction diagram
-
-
-
-
?
ATP + RhoGEF Tus1p
ADP + phosphorylated RhoGEF Tus1p
show the reaction diagram
-
-
-
-
?
ATP + RNA polymerase II largest subunit
ADP + phosphorylated RNA polymerase II largest subunit
show the reaction diagram
specifically hyperphosphorylates the carboxyl-terminal
-
-
?
ATP + Sic1
ADP + phosphorylated Sic1
show the reaction diagram
ATP + Swi5
ADP + phosphorylated Swi5
show the reaction diagram
-
-
-
-
?
ATP + Swi6
ADP + phosphorylated Swi6
show the reaction diagram
-
substrate of cdc28p
-
-
?
ATP + Vac17
ADP + phosphorylated Vac17
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + Gcn4 protein
ADP + phosphorylated Gcn4 protein
show the reaction diagram
-
-
-
?
ATP + Glc8 protein
ADP + phosphorylated Glc8 protein
show the reaction diagram
-
-
-
?
ATP + Gsy2 protein
ADP + phosphorylated Gsy2 protein
show the reaction diagram
-
-
-
?
ATP + Pho4 protein
ADP + phosphorylated Pho4 protein
show the reaction diagram
-
-
-
?
ATP + Rga2 protein
ADP + phosphorylated Rga2 protein
show the reaction diagram
-
-
-
?
ATP + Rim 15 protein
ADP + phosphorylated Rim15 protein
show the reaction diagram
-
-
-
?
ATP + Rvs167 protein
ADP + phosphorylated Rvs167 protein
show the reaction diagram
-
-
-
?
ATP + Sic1 protein
ADP + phosphorylated Sic1 protein
show the reaction diagram
-
-
-
?
ATP + Whi5 G1 protein
ADP + phosphorylated Whi5 G1 protein
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + cyclin-dependent kinase
ADP + phosphorylated cyclin-dependent kinase
show the reaction diagram
-
-
-
?
ATP + Fkh2p
ADP + phosphorylated Fkh2p
show the reaction diagram
-
phosphorylation of forkhead transcription factor Fkh2p is part of regulation of cell cycle-specific gene expression, e.g. of the CLB2 cluster, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation, overview
-
-
?
ATP + Rad9 protein
ADP + Rad9 phosphoprotein
show the reaction diagram
-
a DNA damage response mediator
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cyclin B2
-
i.e. Clb2
-
cyclin B5
-
i.e. Clb5, specificity mechanism, overview
-
cyclin Clb5
-
-
-
cyclin Clb6
-
-
-
cyclin Pcl1
-
-
-
cyclin Pcl10
-
-
-
cyclin Pcl2
-
-
-
cyclin Pcl3
-
-
-
cyclin Pcl4
-
-
-
cyclin Pcl5
-
-
-
cyclin Pcl6
-
-
-
cyclin Pcl7
-
-
-
cyclin Pcl8
-
-
-
cyclin Pcl9
-
-
-
cyclin Pho80
-
-
-
additional information
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Pho81 phosphoprotein
-
-
-
Sic1
-
Cdk inhibitor, double-strand break is not efficiently repaired
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Clbp1-Clbp6
-
cyclins, possible regulatory subunits of Cdc28p, each influencing the enzyme activity in a distinct way, overview
-
cyclin
-
cyclin Cln3
-
stability of Cln3 protein is diminished in strains with low activity of Pho85, a phosphate-sensing CDK. Cln3 is an in vitro substrate of Pho85, and both proteins interact in vivo. In vivo phosphorylation of S449 and T520 is essential to maintain Cln3 levels, Pho85 activity increases the half-life of Cln3 protein
-
Mcm1p
-
regulatory coactivator, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation
-
Ndd1p
-
regulatory coactivator, Fkh2p phosphorylation by Cdc28p is regulated by complex formation with Mcm1p and Ndd1p, and phosphorylation
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.046 - 0.521
ADAQHATPPKKKRKVEDPKDF
0.003
Fin1
-
pH 7.4, Cdk1-as1/cyclin 5B
-
additional information
additional information
-
kinetics of Cdk1-As1 mutant with cyclins 5B and 2B in reaction with different substrates, overview
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.9 - 3.15
ADAQHATPPKKKRKVEDPKDF
1.7
Fin1
-
pH 7.4, Cdk1-as1/cyclin 5B
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
large scale activity assay with recombinant enzyme in a protein chip consisting of a microwell array with protein covalently attached to the wells via a 3-glycidoxypropyltrimethoxysilane crosslinker, overview
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25 - 37
-
in vivo
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35000
x * 35000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 35000, SDS-PAGE
additional information
-
complex formation of the active enzyme, coactivators and substrate, overview
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Pho85-Pcl10 in complex with ATPgammaS, hanging drop vapor diffusion method, using 22-25% (w/v) polyethylene glycol 5000 monomethyl ether, 0.1 M MES, pH 6.4, at 25°C
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Talon column chromatography and Superdex 200 gel filtration
recombinant GST-tagged Pho85 and Pho80 from Escherichia coli strain BL21(DE3) by glutathione affinity chromatography
-
tandem purification of Cdk1 with cyclin B2 or cyclin B5 by affinity chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
Cdk5, DNA sequence determination and analysis
-
expression in Escherichia coli
expression of GST-tagged Pho85 and Pho80 in Escherichia coli strain BL21(DE3)
-
gene encoding the 58 kDa alpha subunit
phylogenetic tree of kinases derived from the kinase core sequence, overview, overexpression as GST-fusion protein under control of the galactose-inducible GAL1 promotor in Escherichia coli, determination of 5'-end sequences
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
development of a protein chip consisting of a silicone elastomer microwell array with recombinant enzyme covalently attached to the wells via a 3-glycidoxypropyltrimethoxysilane crosslinker for large scale activity assay, overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Saiz, J.E.; Buitrago, M.J.; Garcia, R.; Revuelta, J.L.; Del Rey, F.
The sequence of a 20.3 kb DNA fragment from the left arm of Saccharomyces cerevisiae chromosome IV contains the KIN28, MSS2, PHO2, POL3 and DUN1 genes, and six new open reading frames
Yeast
12
1077-1084
1996
Saccharomyces cerevisiae (P06242)
Manually annotated by BRENDA team
Irie, K.; Nomoto, S.; Miyajima, I.; Matsumoto, K.
SGV1 encodes a CDC28/cdc2-related kinase required for a G alpha subunit-mediated adaptive response to pheromone in S. cerevisiae
Cell
65
785-795
1991
Saccharomyces cerevisiae (P23293), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Roemer, T.; Fortin, N.; Bussey, H.
DNA sequence analysis of a 10.4 kbp region on the right arm of yeast chromosome XVI positions GPH1 and SGV1 adjacent to KRE6, and identifies two novel tRNA genes
Yeast
10
1527-1530
1994
Saccharomyces cerevisiae (P23293)
Manually annotated by BRENDA team
Baur, S.; Becker, J.; Li, Z.; Niegemann, E.; Wehner, E.; Wolter, R.; Brendel, M.
Sequence analysis of a 5.6 kb fragment of chromosome II from Saccharomyces cerevisiae reveals two new open reading frames next to CDC28
Yeast
11
455-458
1995
Saccharomyces cerevisiae (P00546), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lorincz, A.T.; Reed, S.I.
Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes
Nature
307
183-185
1984
Saccharomyces cerevisiae (P00546), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Korsisaari, N.; Makela, T.P.
Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins
J. Biol. Chem.
275
34837-34840
2000
Saccharomyces cerevisiae (P06242), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Valay, J.G.; Simon, M.; Faye, G.
The kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae
J. Mol. Biol.
234
307-310
1993
Saccharomyces cerevisiae (P06242)
Manually annotated by BRENDA team
Simon, M.; Seraphin, B.; Faye, G.
KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28
EMBO J.
5
2697-2701
1986
Saccharomyces cerevisiae (P06242), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kaffman, A.; Herskowitz, I.; Tjian, R.; O'Shea, E.K.
Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85
Science
263
1153-1156
1994
Saccharomyces cerevisiae (P17157), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Toh-e, A.; Tanaka, K.; Uesono, Y.; Wickner, R.B.
PHO85, a negative regulator of the PHO system, is a homolog of the protein kinase gene, CDC28, of Saccharomyces cerevisiae
Mol. Gen. Genet.
214
162-164
1988
Saccharomyces cerevisiae (P17157), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Uesono, Y.; Tanaka, K.; Toh-e, A.
Negative regulators of the PHO system in Saccharomyces cerevisiae: isolation and structural characterization of PHO85
Nucleic Acids Res.
15
10299-10309
1987
Saccharomyces cerevisiae (P17157), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Rasmussen, S.W.
A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1 and CSD3 genes, a TCP-1-related gene, an open reading frame similar to the DAL80 gene, and a tRNA(Arg)
Yeast
11
873-883
1995
Saccharomyces cerevisiae (P32581)
Manually annotated by BRENDA team
Yoshida, M.; Kawaguchi, H.; Sakata, Y.; Kominami, K.; Hirano, M.; Shima, H.; Akada, R.; Yamashita, I.
Initiation of meiosis and sporulation in Saccharomyces cerevisiae requires a novel protein kinase homologue
Mol. Gen. Genet.
221
176-186
1990
Saccharomyces cerevisiae (P32581)
Manually annotated by BRENDA team
Lee, J.M.; Greenleaf, A.L.
CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae
Gene Expr.
1
149-167
1991
Saccharomyces cerevisiae (Q03957), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Bussey, H.; Storms, R.K.; Ahmed, A.; Albermann, K.; et al.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI
Nature
387
103-105
1997
Saccharomyces cerevisiae (P17157), Saccharomyces cerevisiae (P23293), Saccharomyces cerevisiae (P39073)
Manually annotated by BRENDA team
Murakami, Y.; Naitou, M.; Hagiwara, H.; Shibata, T.; Ozawa, M.; Sasanuma, S.; Sasanuma, M.; Tsuchiya, Y.; Soeda, E.; Yokoyama, K.; et al.
Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae
Nat. Genet.
10
261-268
1995
Saccharomyces cerevisiae (P43568)
Manually annotated by BRENDA team
Kaldis, P.; Sutton, A.; Solomon, M.J.
The Cdk-activating kinase (CAK) from budding yeast
Cell
86
553-564
1996
Saccharomyces cerevisiae (P43568), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Zhu, H.; Klemic, J.F.; Chang, S.; Bertone, P.; Casamayor, A.; Klemic, K.G.; Smith, D.; Gerstein, M.; Reed, M.A.; Snyder, M.
Analysis of yeast protein kinases using protein chips
Nat. Genet.
26
283-289
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kesavapany, S.; Li, B.S.; Amin, N.; Zheng, Y.L.; Grant, P.; Pant, H.C.
Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide
Biochim. Biophys. Acta
1697
143-153
2004
Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Canis lupus familiaris, Drosophila melanogaster, Homo sapiens, Doryteuthis pealeii, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Pic-Taylor, A.; Darieva, Z.; Morgan, B.A.; Sharrocks, A.D.
Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p
Mol. Cell. Biol.
24
10036-10046
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Loog, M.; Morgan, D.O.
Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates
Nature
434
104-108
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Enders, G.H.; Maude, S.L.
Traffic safety for the cell: influence of cyclin-dependent kinase activity on genomic stability
Gene
371
1-6
2006
Saccharomyces cerevisiae, Homo sapiens
Manually annotated by BRENDA team
Ikui, A.E.; Archambault, V.; Drapkin, B.J.; Campbell, V.; Cross, F.R.
Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition
Genetics
175
1011-1022
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Peng, Y.; Weisman, L.S.
The cyclin-dependent kinase Cdk1 directly regulates vacuole inheritance
Dev. Cell
15
478-485
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kono, K.; Nogami, S.; Abe, M.; Nishizawa, M.; Morishita, S.; Pellman, D.; Ohya, Y.
G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae
Mol. Biol. Cell
19
1763-1771
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae YOC3388
Manually annotated by BRENDA team
Huang, D.; Friesen, H.; Andrews, B.
Pho85, a multifunctional cyclin-dependent protein kinase in budding yeast
Mol. Microbiol.
66
303-314
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Menoyo, S.; Ricco, N.; Bru, S.; Hernandez-Ortega, S.; Escote, X.; Aldea, M.; Clotet, J.
Phosphate-activated cyclin-dependent kinase stabilizes G1 cyclin to trigger cell cycle entry
Mol. Cell. Biol.
33
1273-1284
2013
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Manually annotated by BRENDA team
Abreu, C.M.; Kumar, R.; Hamilton, D.; Dawdy, A.W.; Creavin, K.; Eivers, S.; Finn, K.; Balsbaugh, J.L.; OConnor, R.; Kiely, P.A.; Shabanowitz, J.; Hunt, D.F.; Grenon, M.; Lowndes, N.F.
Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1
PLoS Genet.
9
e1003310
2013
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Zheng, F.; Quiocho, F.A.
New structural insights into phosphorylation-free mechanism for full cyclin-dependent kinase (CDK)-cyclin activity and substrate recognition
J. Biol. Chem.
288
30682-30692
2013
Saccharomyces cerevisiae (P17157), Saccharomyces cerevisiae
Manually annotated by BRENDA team