Information on EC 2.3.1.51 - 1-acylglycerol-3-phosphate O-acyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.3.1.51
-
RECOMMENDED NAME
GeneOntology No.
1-acylglycerol-3-phosphate O-acyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
CDP-diacylglycerol biosynthesis I
-
CDP-diacylglycerol biosynthesis II
-
CDP-diacylglycerol biosynthesis III
-
Glycerolipid metabolism
-
Glycerophospholipid metabolism
-
Metabolic pathways
-
phospholipid remodeling (phosphatidate, yeast)
-
superpathway phosphatidate biosynthesis (yeast)
-
triacylglycerol biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
1-acyl-sn-glycero-3-phosphate acyltransferase
-
-
-
-
1-acyl-sn-glycero-3-phosphate acyltransferase 1
Q99943
-
1-acyl-sn-glycero-3-phosphate acyltransferase 9
-
-
1-acyl-sn-glycerol 3-phosphate acyltransferase
-
-
-
-
1-acyl-sn-glycerol 3-phosphate acyltransferases
-
-
1-acyl-sn-glycerol-3-phosphate acyltransferase
Q643R3
-
1-acyl-sn-glycerol-3-phosphate acyltransferase
-
-
1-acyl-sn-glycerol-3-phosphate acyltransferase
P33333, Q08548
-
1-acylglycero-3-phosphate acyltransferase
-
-
-
-
1-acylglycerol 3-phosphate O-acyltransferase
P33333
-
1-acylglycerol-3-phosphate acyltransferase
-
-
1-acylglycerol-3-phosphate-O-acyltransferase
-
-
1-acylglycerol-3-phosphate-O-acyltransferase
O15120
-
1-acylglycerol-3-phosphate-O-acyltransferase 2
-
-
1-acylglycerol-3-phosphate-O-acyltransferase isoform10/glycerol-3-phosphate acyltransferase isoform 3
-
-
1-acylglycerol-3-phosphate-O-acyltransferase-1
O35083
-
1-acylglycerolphosphate acyltransferase
-
-
-
-
1-acylglycerolphosphate acyltransferase
Q643R3
-
1-acylglycerophosphate acyltransferase
-
-
-
-
1-Agpat2
O15120
-
ABHD5
Q9DBL9
-
acyl-coenzyme A-dependent lysophosphatidic acid acyltransferase
O22975
-
acyltransferase, 1-acylglycerol phosphate
-
-
-
-
AGPAT
O15120
-
AGPAT
Q643R3
-
AGPAT1
Q99943
-
AGPAT1
O35083
-
AGPAT10/GPAT3
-
-
AGPAT11
Q7L5N7
-
AGPAT2
-
-
AGPAT2
O15120
-
AGPAT3
-
-
AGPAT3
Q9NRZ7
-
AGPAT3
C4B4E7
-
AGPAT3
Mus musculus C57BL/6J
C4B4E7
-
-
AGPAT5
Q9NUQ2
-
AGPAT6/GPAT4
-
-
AGPAT9
-
-
At4g24160
O22975
gene name
CGFI-58
Q9DBL9
-
cgi-58 protein
-
-
CGI-58/ABHD5
-
-
coenzyme A-dependent lysophosphatidic acid
-
-
endoplasmic reticulum-located LPAT
Q8LG50
-
ER-located LPAT
Q8LG50
-
ICT1 protein
-
-
LPA acyltransferase
Q8GXU8, Q8L4Y2, Q8LG50, Q9LHN4, Q9SYC8
-
LPAAT
O22975
-
LPAAT
Q643R3
-
LPAAT3
-
-
LPAAT3
Mus musculus C57BL/6J
C4B4E7
-
-
LPAATbeta
O15120
-
LPAT
Q8GXU8, Q8L4Y2, Q8LG50, Q9LHN4, Q9SYC8
-
LPCAT2
Q7L5N7
-
lysophosphatidic acid acyl transferase
-
-
lysophosphatidic acid acyltransferase
-
-
lysophosphatidic acid acyltransferase
Q643R3
-
lysophosphatidic acid acyltransferase
Q99943
-
lysophosphatidic acid acyltransferase
-
-
lysophosphatidic acid acyltransferase 3
-
-
lysophosphatidic acid acyltransferase 3
C4B4E7
-
lysophosphatidic acid acyltransferase 3
Mus musculus C57BL/6J
C4B4E7
-
-
lysophosphatidic acid ayltransferase
-
-
lysophosphatidic acid ayltransferase
-
-
lysophosphatidic acid-acyltransferase
-
-
-
-
lysophosphatidic acid–specific acyltransferase
-
-
lysophosphatidyl acyltransferase
-
-
lysophosphatidyl acyltransferase
Q8GXU8, Q8L4Y2, Q8LG50, Q9LHN4, Q9SYC8
-
mAGPAT1
-
-
mAGPAT2
-
-
mAGPAT3
-
-
mAGPAT4
-
-
oleoyl-CoA lysophosphatidic acid acyltransferase
-
-
SMc00714 protein
-
-
YPR139c
Q06508
-
mAGPAT5
-
-
additional information
O22975
the enzyme belongs to the alpha/beta-hydrolase family
additional information
-
the enzyme belongs to the alpha/beta-hydrolase family
additional information
C4B4E7
the enzyme belongs to the 1-acylglycerol-3-phosphate O-acyltransferase, AGPAT, family
additional information
Mus musculus C57BL/6J
C4B4E7
the enzyme belongs to the 1-acylglycerol-3-phosphate O-acyltransferase, AGPAT, family
-
CAS REGISTRY NUMBER
COMMENTARY
51901-16-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
At4g24160; gene At4g24160
UniProt
Manually annotated by BRENDA team
LPAT1; gene LPAT1
SwissProt
Manually annotated by BRENDA team
LPAT2; gene LPAT2
SwissProt
Manually annotated by BRENDA team
LPAT3; gene LPAT3
SwissProt
Manually annotated by BRENDA team
LPAT4; gene LPAT4
SwissProt
Manually annotated by BRENDA team
LPAT5; gene LPAT5
SwissProt
Manually annotated by BRENDA team
Jersey cow
-
-
Manually annotated by BRENDA team
BAT1.13 and BAT1.5 genes encoding two microsomal LPAAT isozymes
UniProt
Manually annotated by BRENDA team
K12, strains: LCD45 and CE1061
-
-
Manually annotated by BRENDA team
XL1-Blue cells
-
-
Manually annotated by BRENDA team
Euglena sp.
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
AGPAT2; gene AGPAT2
SwissProt
Manually annotated by BRENDA team
gene AGPAT7; gene AGPAT7
SwissProt
Manually annotated by BRENDA team
gene AGPAT8
-
-
Manually annotated by BRENDA team
clone pLAT1
SwissProt
Manually annotated by BRENDA team
clone pLAT2
SwissProt
Manually annotated by BRENDA team
cvs. AC Emerson and Vimy
-
-
Manually annotated by BRENDA team
C57BL/6J mice
UniProt
Manually annotated by BRENDA team
gene AGPAT8
-
-
Manually annotated by BRENDA team
isozymes AGPAT1,2,3, and 5
-
-
Manually annotated by BRENDA team
Mus musculus C57BL/6J
C57BL/6J mice
UniProt
Manually annotated by BRENDA team
cv. Douce Provence; pea, cv. Kleine Rheinlaenderin
-
-
Manually annotated by BRENDA team
pea, cv. Kleine Rheinlaenderin
-
-
Manually annotated by BRENDA team
16 strains, genotypes listed
SwissProt
Manually annotated by BRENDA team
BY4741 and deletion mutant strain of ICT1 protein in BY4741-background
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae OC-2
OC-2
-
-
Manually annotated by BRENDA team
gene plsC or SMc00714, strain RmP110
-
-
Manually annotated by BRENDA team
spinach, cv. Mona Lisa
-
-
Manually annotated by BRENDA team
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Mg2+
Q9XFW4
-
additional information
-
no Mg2+-requirement
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.6
8.6
-
about half-maximal activity at pH 6.6 and 8.6
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.5
7.5
-
lowering the assay pH from 7.5 to 6.5 results in a loss of approximately 20% of the enzyme activity
Renatured/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
reassociation of the solubilized enzyme with soybean phospholipids
-
by mixing 1 vol. of the fraction containing the enzyme with 4 vol. of sonicated phosphatidylcholine/phosphatidylglycerol or total E. coli lipid vesicles
-