Cloned (Comment) | Organism |
---|---|
expression in C2C12 cell | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoskeleton | isoform AGPAT1 localizes to cytoskeletal components, particularly to areas of actin polymerization in myoblasts | Mus musculus | 5856 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O35083 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
1-acylglycerol-3-phosphate-O-acyltransferase-1 | - |
Mus musculus |
AGPAT1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform AGPAT1 is involved in development of skeletal muscle. Small interference RNA-mediated knockdown of AGPAT1 expression prevents the induction of myogenin, and inhibits the expression of myosin heavy chain. This effect is rescued by transfection with AGPAT1 but not AGPAT2. The regulation of myogenesis by AGPAT1 is associated with alterations on actin cytoskeleton. AGPAT1 colocalizes AGPAT1 to areas of active actin polymerization. AGPAT1 overexpression is not associated with an increase in phosphatidic acid levels | Mus musculus |