Cloned (Comment) | Organism |
---|---|
gene AGPAT2, expression of C-terminally HA-tagged AGPAT2 in CHO-K1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | small interference RNA-mediated knockdown of AGPAT2 expression in OP-9 cells prevents appropriate early induction of C/EBPbeta and PPARgamma, key transcriptional activators of the adipogenic program, and delays expression of multiple adipocyte-related genes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | AGPAT2 is an integral membrane protein | Homo sapiens | 5783 | - |
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate | Homo sapiens | AGPAT2 catalyzes acylation of lysophosphatidic acid to phosphatidic acid, a precursor for both triacylglycerol and phospholipid synthesis, isozyme AGPAT2 plays a regulatory role in adipocyte differentiation | CoA + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15120 | AGPAT2; gene AGPAT2 | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme partially from CHO-K1 cell microsomes | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | isozyme AGPAT2 | Homo sapiens | - |
OP-9 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate | - |
Homo sapiens | CoA + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate | AGPAT2 catalyzes acylation of lysophosphatidic acid to phosphatidic acid, a precursor for both triacylglycerol and phospholipid synthesis, isozyme AGPAT2 plays a regulatory role in adipocyte differentiation | Homo sapiens | CoA + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
1-acylglycerol-3-phosphate-O-acyltransferase | - |
Homo sapiens |
AGPAT | - |
Homo sapiens |