Information on EC 1.18.1.2 - ferredoxin-NADP+ reductase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY
1.18.1.2
-
RECOMMENDED NAME
GeneOntology No.
ferredoxin-NADP+ reductase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Metabolic pathways
-
Photosynthesis
-
photosynthesis light reactions
-
ubiquinol-6 biosynthesis from 4-aminobenzoate (eukaryotic)
-
SYSTEMATIC NAME
IUBMB Comments
ferredoxin:NADP+ oxidoreductase
A flavoprotein (FAD). In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe-2S] ferredoxins, but in other bacteria it can also reduce bacterial [4Fe-4S] ferredoxins and flavodoxin.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
adrenodoxin reductase
-
-
-
-
adrenodoxin reductase
-
-
AnFNR
-
FNR from Anabaena PCC 7119
cytochrome b6f -associated ferredoxin:NADP+ oxidoreductase
-
-
DA1
-
-
-
-
EC 1.6.7.1
-
-
formerly
-
EC 1.6.99.4
-
-
formerly
-
Fd-NADP+ reductase
-
-
Fd-NADP+ reductase
Chlorobaculum tepidum CT1512
-
-
-
Fd-NADP+ reductase
-
-
Fd-NADP+ reductase
-
-
Fd-NADP+ reductase
-
-
ferredoxin (flavodoxin)-(reduced) nicotinamide adenine dinucleotide phosphate reductase
Q9L6V3
-
ferredoxin (flavodoxin)-(reduced) nicotinamide adenine dinucleotide phosphate reductase
Rhodobacter capsulatus 37b4
Q9L6V3
-
-
ferredoxin (flavodoxin)-NADP(H) reductase
-
-
ferredoxin (flavodoxin)-NADP(H) reductase
Anabaena sp. PCC7119
-
-
-
ferredoxin (flavodoxin)-NADP(H) reductase
Q9L6V3
-
ferredoxin (flavodoxin)-NADP(H) reductase
Rhodobacter capsulatus 37b4
Q9L6V3
-
-
ferredoxin (flavodoxin)-NADP(H) reductase
-
-
ferredoxin (flavodoxin):NADP+ oxidoreductase
-
-
ferredoxin NADP reductase
-
-
ferredoxin NADP+ oxidoreductase
Q8RVZ8, Q8RVZ9
-
ferredoxin NADP+ oxidoreductase
Triticum aestivum Paragon
Q8RVZ8, Q8RVZ9
-
-
ferredoxin NADP+ reductase
-
-
ferredoxin nicotinamide adenine dinucleotide phosphate reductase
-
-
ferredoxin-NADP oxidoreductase
-
-
-
-
ferredoxin-NADP reductase
-
-
-
-
ferredoxin-NADP reductase
-
-
Ferredoxin-NADP(+) reductase
-
-
-
-
Ferredoxin-NADP(+) reductase
-
-
Ferredoxin-NADP(+) reductase
Chlorobaculum tepidum CT1512
-
-
-
Ferredoxin-NADP(+) reductase
-
-
Ferredoxin-NADP(+) reductase
-
-
ferredoxin-NADP(H) oxidoreductase
-
-
ferredoxin-NADP(H) reductase
-
-
ferredoxin-NADP(H) reductase
Anabaena sp. PCC7119
-
-
-
ferredoxin-NADP(H) reductase
-
-
ferredoxin-NADP(H) reductase
-
-
ferredoxin-NADP(H) reductase
-
-
ferredoxin-NADP(H) reductase
-
-
ferredoxin-NADP+ oxidoreductase
F4JZ46
-
ferredoxin-NADP+ oxidoreductase
Q8W493
-
ferredoxin-NADP+ oxidoreductase
Q9FKW6
-
ferredoxin-NADP+ oxidoreductase
-
-
ferredoxin-NADP+ oxidoreductase
Arthrospira platensis IAM M-135
-
-
-
ferredoxin-NADP+ oxidoreductase
-
-
ferredoxin-NADP+ oxidoreductase
O05268
-
ferredoxin-NADP+ oxidoreductase
-
-
ferredoxin-NADP+ oxidoreductase
Q93RE3
-
ferredoxin-NADP+ oxidoreductase
-
-
ferredoxin-NADP+ oxidoreductase
Synechocystis sp. 6803
-
-
-
ferredoxin-NADP+ oxidoreductase
Q8RVZ8, Q8RVZ9
-
ferredoxin-NADP+ oxidoreductase
Q9SLP6
-
ferredoxin-NADP+ reductase
-
-
ferredoxin-NADP+ reductase
P28861
-
ferredoxin-NADP+ reductase
-
-
ferredoxin-NADP+ reductase
-
-
-
ferredoxin-NADP+ reductase
-
-
ferredoxin-NADP+ reductase
-
-
ferredoxin-NADP+ reductase
-
-
ferredoxin-NADP+ reductase
-
-
ferredoxin-NADP+ reductase
-
-
ferredoxin-NADP+ reductase
-
-
ferredoxin-NADP+ reductase
-
-
ferredoxin-NADP+-oxidoreductase
Q8W493, Q9FKW6
-
ferredoxin-NADP+-reductase
-
-
ferredoxin-NADP-oxidoreductase
-
-
-
-
ferredoxin-NADP-reductase
-
-
ferredoxin-nicotinamide adenine dinucleotide phosphate reductase
-
-
ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase
-
-
-
-
ferredoxin-TPN reductase
-
-
-
-
ferredoxin:NADP(+) oxidoreductase
-
-
ferredoxin:NADP(+) oxidoreductase
Q8RVZ8, Q8RVZ9
-
ferredoxin:NADP+ oxidoreductase
-
-
-
-
ferredoxin:NADP+ oxidoreductase
-
-
ferredoxin:NADP+ oxidoreductase
-
-
ferredoxin:NADP+ reductase
Q5CVU8
-
ferredoxin:NADP+ reductase
Cryptosporidium parvum IOWA-1
Q5CVU8
-
-
ferredoxin:NADPH oxidoreductase
-
-
ferric reductase
P28861
-
Flavodoxin reductase
-
-
-
-
FLDR
-
-
-
-
FLXR
-
-
-
-
FNR
-
-
-
-
FNR
Anabaena sp. PCC7119
-
-
-
FNR
Arthrospira platensis IAM M-135
-
-
-
FNR
O05268
-
FNR
Chlorobaculum tepidum CT1512
-
-
-
FNR
Synechocystis sp. 6803
-
-
-
FNR
Q8RVZ8, Q8RVZ9
-
FNR
Triticum aestivum Paragon
Q8RVZ8, Q8RVZ9
-
-
FNR
Q9SLP6
-
FNR-A
Q8RVZ9
isozyme
FNR-B
Q8RVZ8
isozyme
FNR1
Q9FKW6
In Arabidopsis thaliana, two distinct chloroplast-targeted FNR isoforms, FNR1 and FNR2, are encoded by nuclear genes At5g66190 and At1g20020, respectively. In wild-type plants, both FNR isoforms exist partially in soluble form in the stroma and partially attached to the thylakoid membrane, as well as to the inner envelope membrane of the chloroplast.
FNR2
Q8W493
In Arabidopsis thaliana, two distinct chloroplast-targeted FNR isoforms, FNR1 and FNR2, are encoded by nuclear genes At5g66190 and At1g20020, respectively. In wild-type plants, both FNR isoforms exist partially in soluble form in the stroma and partially attached to the thylakoid membrane, as well as to the inner envelope membrane of the chloroplast.
FPR
P28861
-
FPR
Rhodobacter capsulatus 37b4
Q9L6V3
-
-
FprA
-
Pseudomonas putida harbors two ferredoxin-NADP+ reductases FprA and FprB on its chromosome.
FprB
-
Pseudomonas putida harbors two ferredoxin-NADP+ reductases FprA and FprB on its chromosome.
LFNR1
Q9FKW6
isozyme, involved in linear electron transfer and thereby affects the function of the Calvin cycle
LFNR2
Q8W493
isozyme
mitochondrial-type ferredoxin:NADP+ reductase
Q5CVU8
-
mtFNR
Cryptosporidium parvum IOWA-1
Q5CVU8
-
-
NADP:ferredoxin oxidoreductase
-
-
-
-
NADPH ferredoxin reductase
-
-
NADPH-dependent ferredoxin reductase
-
-
NADPH:ferredoxin oxidoreductase
-
-
-
-
NFR
-
-
-
-
PfFNR
-
ferredoxin-NADP+ reductase of Plasmodium falciparum
pFNR
Q8RVZ8, Q8RVZ9
-
pFNR
Triticum aestivum Paragon
Q8RVZ8, Q8RVZ9
-
-
photosynthetic ferredoxin NADP+ oxidoreductase
Q8RVZ8, Q8RVZ9
-
photosynthetic ferredoxin NADP+ oxidoreductase
Triticum aestivum Paragon
Q8RVZ8, Q8RVZ9
-
-
photosynthetic FNR
Q8RVZ8, Q8RVZ9
-
photosynthetic FNR
Triticum aestivum Paragon
Q8RVZ8, Q8RVZ9
-
-
reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase
-
-
-
-
reductase, ferredoxin-nicotinamide adenine dinucleotide phosphate
-
-
-
-
ST2133
Q96YN9
locus name
ST2133
Sulfolobus tokodaii 7
Q96YN9
locus name
-
TPNH-ferredoxin reductase
-
-
-
-
mitochondrial-type ferredoxin:NADP+ reductase
Cryptosporidium parvum IOWA-1
Q5CVU8
-
-
additional information
-
enzyme belongs to the plant-type enzyme family
additional information
Anabaena sp. PCC7119
-
enzyme belongs to the plant-type enzyme family
-
additional information
-
leaf-type, or chloroplast, or photosynthetic LFNR
additional information
-
enzyme belongs to the bacterial-type enzyme family
additional information
-
enzyme belongs to the plant-type enzyme family
additional information
-
enzyme belongs more to the plant-type enzyme family than to the bacterial-type enzyme family
additional information
-
enzyme belongs to the bacterial-type enzyme family
additional information
-
enzyme belongs to the plant-type enzyme family, result of lateral gene transfer
additional information
-
leaf-type, or chloroplast, or photosynthetic LFNR
additional information
-
formerly termed thylakoid-bound diaphorase
additional information
-
enzyme belongs to the plant-type enzyme family
additional information
-
leaf-type, or chloroplast, or photosynthetic LFNR
CAS REGISTRY NUMBER
COMMENTARY
56367-57-8
-
9029-33-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
cyanobacterium
-
-
Manually annotated by BRENDA team
PCC 7119
-
-
Manually annotated by BRENDA team
PCC 7119
Uniprot
Manually annotated by BRENDA team
PCC7119
-
-
Manually annotated by BRENDA team
petH gene product
-
-
Manually annotated by BRENDA team
strain 7119, multiple forms: FNR-I, FNR-II, FNR-III, FNR-IV
-
-
Manually annotated by BRENDA team
strain PCC 7119
-
-
Manually annotated by BRENDA team
strain PCC7119
-
-
Manually annotated by BRENDA team
Anabaena sp. 7119
strain 7119, multiple forms: FNR-I, FNR-II, FNR-III, FNR-IV
-
-
Manually annotated by BRENDA team
Anabaena sp. PCC7119
PCC7119
-
-
Manually annotated by BRENDA team
Anabaena sp. PCC7119
strain PCC7119
-
-
Manually annotated by BRENDA team
cyanobacterium
-
-
Manually annotated by BRENDA team
ecotype Columbia
UniProt
Manually annotated by BRENDA team
isozyme FNRI; plastidic isozyme FNRI, gene FNR2
UniProt
Manually annotated by BRENDA team
isozyme FNRII; plastidic isozyme FNRII, gene FNR1
UniProt
Manually annotated by BRENDA team
two LFNR isoforms, LFNR1 and LFNR2
-
-
Manually annotated by BRENDA team
wild type and T-DNA insertion line fnr1 (lacking FNR1) and RNAi line fnr2 (lacking FNR2)
UniProt
Manually annotated by BRENDA team
2 forms: FNRS I and FNRS II
-
-
Manually annotated by BRENDA team
strain IAM M-135, cyanobacterium
-
-
Manually annotated by BRENDA team
Arthrospira platensis IAM M-135
strain IAM M-135, cyanobacterium
-
-
Manually annotated by BRENDA team
gene yumC
UniProt
Manually annotated by BRENDA team
marine green algae
-
-
Manually annotated by BRENDA team
xanthophycean algae
-
-
Manually annotated by BRENDA team
paprika
Uniprot
Manually annotated by BRENDA team
strain CT1512
-
-
Manually annotated by BRENDA team
Chlorobaculum tepidum CT1512
strain CT1512
-
-
Manually annotated by BRENDA team
single copy FNR
UniProt
Manually annotated by BRENDA team
Cryptosporidium parvum IOWA-1
single copy FNR
UniProt
Manually annotated by BRENDA team
strain RK-1, red alga
Uniprot
Manually annotated by BRENDA team
Cyanidium caldarium RK-1
strain RK-1, red alga
Uniprot
Manually annotated by BRENDA team
chick
-
-
Manually annotated by BRENDA team
parasitic bacterium
-
-
Manually annotated by BRENDA team
cyanobacterium strain 7119
-
-
Manually annotated by BRENDA team
strain MAC, cyanobacterium
-
-
Manually annotated by BRENDA team
strain MAC, cyanobacterium
-
-
Manually annotated by BRENDA team
expression in Nicotiana tabacum
-
-
Manually annotated by BRENDA team
multiple isoenzymes
-
-
Manually annotated by BRENDA team
strain KT2440
-
-
Manually annotated by BRENDA team
strain KT2440, wild type and mutants
-
-
Manually annotated by BRENDA team
strain KT2440, wild type and mutants fprA (lacking FprA) and fprB (lacking FprB)
-
-
Manually annotated by BRENDA team
radish, var acanthiformis cultivar miyashige
-
-
Manually annotated by BRENDA team
Wistar, male, H18H
-
-
Manually annotated by BRENDA team
strain 37b4
SwissProt
Manually annotated by BRENDA team
Rhodobacter capsulatus 37b4
strain 37b4
SwissProt
Manually annotated by BRENDA team
induction by treatment of worms with reactive oxygen species generating compounds
Uniprot
Manually annotated by BRENDA team
2 FNR isozymes
-
-
Manually annotated by BRENDA team
2 forms: P-1, P-2
-
-
Manually annotated by BRENDA team
2 tissue-specific isozymes in leaf and root
-
-
Manually annotated by BRENDA team
5 molecular forms: a, b, c, d, e
-
-
Manually annotated by BRENDA team
6 different forms differ in specific activities in various assay systems and affinity for NADPH, interconvertible at 4C
-
-
Manually annotated by BRENDA team
ferredoxin NADP reductase binding protein is not related to CF0II
-
-
Manually annotated by BRENDA team
spinach, multiple forms
-
-
Manually annotated by BRENDA team
strain Atlanta
-
-
Manually annotated by BRENDA team
Spinacia oleracea Atlanta
strain Atlanta
-
-
Manually annotated by BRENDA team
blue-green algae
-
-
Manually annotated by BRENDA team
Sulfolobus tokodaii 7
-
SwissProt
Manually annotated by BRENDA team
i.e. Thermosynechococcus elongatus, single copy gene petH
SwissProt
Manually annotated by BRENDA team
strain PCC 7002, gene petH
-
-
Manually annotated by BRENDA team
thermophilic blue-green algae
-
-
Manually annotated by BRENDA team
PCC6803, gene petH
-
-
Manually annotated by BRENDA team
strain PCC6803, two isoforms of enzyme, produced from the same gene via an internal ribosome entry site within the ORF. Isoform FNRS specifically accumulates under heterotrophic conditions, isoform FNRL contains an N-terminal domain that allows its association with the phycobilisome
SwissProt
Manually annotated by BRENDA team
Synechocystis sp. 6803
-
-
-
Manually annotated by BRENDA team
Synechocystis sp. PCC6803
strain PCC6803, two isoforms of enzyme, produced from the same gene via an internal ribosome entry site within the ORF. Isoform FNRS specifically accumulates under heterotrophic conditions, isoform FNRL contains an N-terminal domain that allows its association with the phycobilisome
SwissProt
Manually annotated by BRENDA team
isozyme FNRI with subforms pFNRISKKQ and pFNRIKKVS; four photosynthetic pFNR protein isoforms
UniProt
Manually annotated by BRENDA team
isozyme FNRI; isozyme FNRI, gene FNRI or FNR-B
UniProt
Manually annotated by BRENDA team
isozyme FNRII with subforms pFNRIIISKK and pFNRIIKKQD; four photosynthetic pFNR protein isoforms
UniProt
Manually annotated by BRENDA team
isozyme FNRII; isozyme FNRII, gene FNRII
UniProt
Manually annotated by BRENDA team
Triticum aestivum Paragon
isozyme FNRI with subforms pFNRISKKQ and pFNRIKKVS; four photosynthetic pFNR protein isoforms
UniProt
Manually annotated by BRENDA team
Triticum aestivum Paragon
isozyme FNRII with subforms pFNRIIISKK and pFNRIIKKQD; four photosynthetic pFNR protein isoforms
UniProt
Manually annotated by BRENDA team
corn root
-
-
Manually annotated by BRENDA team
isozyme FNRII; isozyme FNRII, gene L-FNRII or FNR2; isozyme FNRI; isozyme FNRI, gene L-FNRI or FNR1
UniProt
Manually annotated by BRENDA team
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.5
10
-
ferredoxin-dependent activity at pH 6.5 is 70 micromol/min/mg, at pH 7 is 95 micromol/min/mg and at pH 10 is 30 micromol/min/mg
6.5
9.5
A0ZSY5
ferredoxin-dependent activity at pH 6.5 is 110 micromol/min/mg, at pH 7 is 140 micromol/min/mg and at pH 9.5is 25 micromol/min/mg
6.8
8.2
-, Q5CVU8
assay range
7.5
10
-
quinone-dependent activity at pH 7.5 is 60 micromol/min/mg, at pH 9.7 is 280 micromol/min/mg and at pH 10 is 260 micromol/min/mg
7.5
10
A0ZSY5
quinone-dependent activity at pH 7.5 is 60 micromol/min/mg, at pH 9.7 is 400 micromol/min/mg and at pH 10 is 325 micromol/min/mg
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
25
70
Q93RE3
activity at 52C is 3fold higher than activity at 25C
PDB
SCOP
CATH
ORGANISM
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Nostoc sp. (strain ATCC 29151 / PCC 7119)
Plasmodium falciparum (isolate 3D7)
Plasmodium falciparum (isolate 3D7)
Plasmodium falciparum (isolate 3D7)
Plasmodium falciparum (isolate 3D7)
Plasmodium falciparum (isolate 3D7)
Pseudomonas sp. (strain KKS102)
Pseudomonas sp. (strain KKS102)
Pseudomonas sp. (strain KKS102)
Pseudomonas sp. (strain KKS102)
Pseudomonas sp. (strain KKS102)
Pseudomonas sp. (strain KKS102)
Pseudomonas sp. (strain KKS102)
Pseudomonas sp. (strain KKS102)
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Xanthomonas axonopodis pv. citri (strain 306)
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.5
7.5
-
reduced thermal inactivation rate at this pH-range
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
37
-
-
inactivation of the enzyme due to irreversible protein unfolding and dissociation of the FADH2 cofactor, slower process with binding of ferredoxin, FAD, or flavodoxin, best by riboflavin, overview
41
-
-
inactivation of the reduced enzyme
55
-
-
recombinant chimeric enzyme is slightly less stable than the wild-type parent isozymes
65
-
-
no loss of activity at 65C after incubation for 5 min
66
-
-
inactivation of the oxidized enzyme
70
-
Q93RE3
5 min, completely stable
76
-
-
50% loss of activity after 5 min
80
-
Q93RE3
5 min, loss of 60% activity
85
-
Q93RE3
5 min, inactivation
additional information
-
-
rapid thermal inactivation of reduced enzyme