Information on EC 1.18.1.2 - ferredoxin-NADP+ reductase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
1.18.1.2
-
RECOMMENDED NAME
GeneOntology No.
ferredoxin-NADP+ reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Metabolic pathways
-
-
photosynthesis
-
-
Photosynthesis
-
-
photosynthesis light reactions
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ubiquinol-6 biosynthesis from 4-aminobenzoate (eukaryotic)
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-
SYSTEMATIC NAME
IUBMB Comments
ferredoxin:NADP+ oxidoreductase
A flavoprotein (FAD). In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe-2S] ferredoxins, but in other bacteria it can also reduce bacterial [4Fe-4S] ferredoxins and flavodoxin.
CAS REGISTRY NUMBER
COMMENTARY hide
56367-57-8
-
9029-33-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
cyanobacterium
-
-
Manually annotated by BRENDA team
strain 7119, multiple forms: FNR-I, FNR-II, FNR-III, FNR-IV
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Manually annotated by BRENDA team
strain IAM M-135, cyanobacterium
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-
Manually annotated by BRENDA team
marine green algae
-
-
Manually annotated by BRENDA team
strain CT1512
-
-
Manually annotated by BRENDA team
strain CT1512
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-
Manually annotated by BRENDA team
single copy FNR
UniProt
Manually annotated by BRENDA team
single copy FNR
UniProt
Manually annotated by BRENDA team
strain RK-1, red alga
Uniprot
Manually annotated by BRENDA team
strain RK-1, red alga
Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
cyanobacterium strain 7119
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
chick
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain TK-6
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-
Manually annotated by BRENDA team
strain TK-6
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-
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Nostoc sp. ATCC 29151
-
UniProt
Manually annotated by BRENDA team
strain MAC, cyanobacterium
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
bean
-
-
Manually annotated by BRENDA team
radish, var acanthiformis cultivar miyashige
-
-
Manually annotated by BRENDA team
strain 37b4
SwissProt
Manually annotated by BRENDA team
induction by treatment of worms with reactive oxygen species generating compounds
Uniprot
Manually annotated by BRENDA team
strain Atlanta
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
i.e. Thermosynechococcus elongatus, single copy gene petH
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
pv. citri
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,4-benzoquinone + NADP+
? + NADPH + H+
show the reaction diagram
1,4-naphthoquinone + NADP+
? + NADPH + H+
show the reaction diagram
1,8-dihydroxy-9,10-anthraquinone + NADP+
? + NADPH + H+
show the reaction diagram
2 ferricyanide + NAD(P)H
2 ferrocyanide + NAD(P)+ + H+
show the reaction diagram
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
show the reaction diagram
-
-
-
?
2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
show the reaction diagram
2 ferricytochrome c2 + NADPH
2 ferrocytochrome c2 + NADP+ + H+
show the reaction diagram
2 ferrocytochrome c + NAD+ + H+
2 ferricytochrome c + NADH
show the reaction diagram
2 oxidized ferredoxin + NADH + H+
2 reduced ferredoxin + NAD+
show the reaction diagram
2 oxidized ferredoxin + NADPH + H+
2 reduced ferredoxin + NADP+
show the reaction diagram
2 reduced ferredoxin + NAD+
2 oxidized ferredoxin + NADH + H+
show the reaction diagram
NAD+ is a poor substrate
-
-
?
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
show the reaction diagram
2 reduced ferricyanide + NADP+
2 oxidized ferricyanide + NADPH
show the reaction diagram
2,3-dichloro-1,4-naphthoquinone + NADP+
? + NADPH + H+
show the reaction diagram
2,3-diglutathionyl-1,4-naphthoquinone + NADP+
? + NADPH + H+
show the reaction diagram
2,5-dimethyl-1,4-benzoquinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.07 V
-
-
?
2,6-dichlorophenolindophenol + NADH
NAD+ + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
2,6-dichlorophenolindophenol + NADP+
reduced 2,6-dichlorophenolindophenol + NADPH
show the reaction diagram
-
diaphorase activity
-
-
?
2,6-dichlorophenolindophenol + NADPH + H+
?
show the reaction diagram
-
-
-
?
2,6-dichlorophenolindophenol + NADPH + H+
reduced 2,6-dichlorophenolindophenol + NADP+
show the reaction diagram
-
-
-
?
2-(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyltetrazolium chloride + NADPH
?
show the reaction diagram
-
-
-
?
2-(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyltetrazolium chloride + NADPH
? + NADP+
show the reaction diagram
-
-
-
?
2-hydroxy-1,4-naphthoquinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.41 V
-
-
?
2-methyl-1,4-benzoquinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential 0.01 V
-
-
?
2-methyl-1,4-naphthoquinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.20 V
-
-
?
2-methyl-3-glutathionyl-1,4-naphthoquinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.16 V
-
-
?
2-methyl-3-hydroxy-1,4-naphthoquinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.46 V
-
-
?
2-methyl-5-hydroxy-1,4-naphthoquinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.16 V
-
-
?
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide + NADPH + H+
? + NADP+
show the reaction diagram
5,8-dihydroxy-1,4-naphthoquinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.11 V
-
-
?
5-hydroxy-1,4-naphthoquinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.09 V
-
-
?
9,10-phenanthrenequinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.12 V
-
-
?
aclacinomycin A + NADP+
7-deoxyaklavinone + NADPH
show the reaction diagram
-
under anaerobic conditions
-
-
?
cytochrome c + NADPH + H+
?
show the reaction diagram
weakest substrate
-
-
?
daunomycin + NADP+
7-deoxydaunomycinone + NADPH
show the reaction diagram
-
under anaerobic conditions
-
-
?
daunorubicin + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.34 V
-
-
?
dibromothymoquinone + NADPH
? + NADP+
show the reaction diagram
-
diaphorase activity, no direct involvement of thiol or amino groups in the reaction
-
-
?
dibromothymoquinone + NADPH
reduced dibromothymoquinone + NADP+
show the reaction diagram
FAD + NADPH + H+
reduced FAD + NADP+
show the reaction diagram
-
-
-
?
Fe(III)-citrate + NADH
reduced Fe(III)-citrate + NAD+
show the reaction diagram
-
-
-
-
?
Fe(III)-citrate + NADPH
reduced Fe(III)-citrate + NADP+
show the reaction diagram
-
-
-
-
?
Fe(III)-deferoxamine + NADPH + H+
?
show the reaction diagram
-
-
-
?
Fe(III)-diethylenetriamine-N,N,N',N'',N''-pentaacetic acid + NADPH + H+
Fe(II) + diethylenetriamine-N,N,N',N'',N''-pentaacetic acid + NADP+
show the reaction diagram
highest activity
-
-
?
Fe(III)-EDTA + NADH
reduced Fe(III)-EDTA + NAD+
show the reaction diagram
-
-
-
-
?
Fe(III)-EDTA + NADPH
reduced Fe(III)-EDTA + NADP+
show the reaction diagram
-
-
-
-
?
Fe(III)-EDTA + NADPH + H+
Fe(II) + EDTA + NADP+
show the reaction diagram
Fe(III)-ferrichrome + NADPH + H+
?
show the reaction diagram
-
-
-
?
Fe(III)-nitrilotriacetic acid + NADPH + H+
Fe(II) + nitrilotriacetic acid + NADP+
show the reaction diagram
-
-
-
?
ferric citrate + NADPH + H+
?
show the reaction diagram
-
-
-
?
ferric enterobactin + NADPH + H+
?
show the reaction diagram
lowest activity
-
-
?
ferricyanide + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron acceptor, single electron reduction potential 0.41 V
-
-
?
Fe[EDTA]- + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron acceptor, single electron reduction potential 0.12 V
-
-
?
flavodoxin + cytochrome c
reduced flavodoxin + NADP+ + reduced cytochrome c
show the reaction diagram
-
-
-
-
r
FMN + NADPH + H+
reduced FMN + NADP+
show the reaction diagram
-
-
-
?
K3Fe(CN)6 + NAD(P)H
?
show the reaction diagram
-
-
-
?
K3Fe(CN)6 + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
menogarol + NADP+
7-deoxynogarol + NADPH
show the reaction diagram
-
under anaerobic conditions
-
-
?
methyl viologen + NADPH
reduced methyl viologen + NADP+
show the reaction diagram
methylviologen + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron acceptor, single electron reduction potential -0.44 V
-
-
?
NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol
NAD(P)+ + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
NADH + FAD
NAD+ + reduced FAD
show the reaction diagram
-
assay contains glucose-6-phosphate and glucose-6-phosphate dehydrogenase to recover NADH
-
-
?
NADH + K3Fe(CN)6
NAD+ + reduced K3Fe(CN)6
show the reaction diagram
-
-
-
-
r
NADPH + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium chloride
NADP+ + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium chloride
show the reaction diagram
-
-
-
-
?
NADPH + acceptor
NADP+ + reduced acceptor
show the reaction diagram
NADPH + FAD
NADP+ + reduced FAD
show the reaction diagram
-
assay contains glucose-6-phosphate and glucose-6-phosphate dehydrogenase to recover NADPH
-
-
?
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
NADP+ + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
NADPH + K3Fe(CN)6
NADP+ + reduced K3Fe(CN)6
show the reaction diagram
NADPH + oxidized cytochrome c
NADP+ + reduced cytochrome c
show the reaction diagram
-
-
-
-
r
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
show the reaction diagram
nogalamycin + NADP+
7-deoxynogalarol + NADPH
show the reaction diagram
-
under anaerobic conditions
-
-
?
oxidized ferredoxin + NADH
reduced ferredoxin + NAD+
show the reaction diagram
-
very slow and inefficient reaction
-
-
?
oxidized ferredoxin + NADH + cytochrome c
reduced ferredoxin + NAD+ + reduced cytochrome c
show the reaction diagram
-
-
-
-
r
oxidized ferredoxin + NADPH
reduced ferredoxin + NADP+
show the reaction diagram
oxidized ferredoxin + NADPH + cytochrome c
reduced ferredoxin + NADP+ + reduced cytochrome c
show the reaction diagram
oxidized flavodoxin + NADH + cytochrome c
reduced flavodoxin + NAD+ + reduced cytochrome c
show the reaction diagram
-
-
-
-
r
oxidized flavodoxin + NADPH
reduced flavodoxin + NADP+
show the reaction diagram
oxidized flavodoxin + NADPH + cytochrome c
reduced flavodoxin + NADP+ + reduced cytochrome c
show the reaction diagram
-
assay contains glucose-6-phosphate and glucose-6-phosphate dehydrogenase to recover NADPH
-
-
r
oxidized flavodoxin I + NADPH
reduced flavodoxin I + NADP+
show the reaction diagram
-
-
-
-
r
oxidized flavodoxin II + NADPH
reduced flavodoxin II + NADP+
show the reaction diagram
-
-
-
-
r
oxidized iodonitrotetrazolium violet + NADPH
reduced iodonitrotetrazolium violet + NADP+
show the reaction diagram
-
-
-
-
?
oxidized rubredoxin + NADP+
reduced rubredoxin + NADPH
show the reaction diagram
-
Clostridium pasteurianum rubredoxin
-
-
?
phenyl-p-benzoquinone + NADPH + cytochrome c
? + NADP+ + reduced cytochrome c
show the reaction diagram
plastoquinone + NADPH
? + NADP+
show the reaction diagram
-
plastoquinones with different length of side chains from spinach, preference for short chain substrate, reaction proceeds via a FMN and a semiquinone intermediate, incorporation of the substrate into sodium cholate micelles is required for activity, micelles structure scheme
-
-
?
reduced ferredoxin + NAD(P)+
oxidized ferredoxin + NAD(P)H
show the reaction diagram
reduced ferredoxin + NAD+
oxidized ferredoxin + NADH
show the reaction diagram
-
the rate of NADH oxidation by FNR is lower than that with NADPH
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
show the reaction diagram
reduced ferredoxin I + NADP+
oxidized ferredoxin I + NADPH
show the reaction diagram
-
-
-
-
r
reduced flavodoxin + NADP+
oxidized flavodoxin + NADPH
show the reaction diagram
tetramethyl-1,4-benzoquinone + NADP+
? + NADPH + H+
show the reaction diagram
-
single electron reduction potential -0.26 V
-
-
?
[4Fe-4S]-ferredoxin + NADPH
reduced [4Fe-4S]-ferredoxin + NADP+
show the reaction diagram
-
[4Fe-4S]-ferredoxin of Pseudomonas putida is similar to ferredoxin FdI of Azotobacter vinelandii, the Pseudomonas putida chromosome contains two [2Fe-2S] ferredoxins (FdA and FdB), three [4Fe-4S] ferredoxins (4FdA, 4FdB and FdxA) and one flavodoxin (Fld)
-
-
r
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 reduced ferredoxin + NADP+
2 oxidized ferredoxin + NADPH + H+
show the reaction diagram
NADPH + oxidized ferredoxin
NADP+ + reduced ferredoxin
show the reaction diagram
oxidized ferredoxin + NADPH
reduced ferredoxin + NADP+
show the reaction diagram
oxidized flavodoxin + NADPH
reduced flavodoxin + NADP+
show the reaction diagram
-
flavodoxin-dependent enzyme radical generation and enzyme activation, electron supply from NADPH
-
-
?
oxidized flavodoxin I + NADPH
reduced flavodoxin I + NADP+
show the reaction diagram
-
-
-
-
r
reduced ferredoxin + NADP+
oxidized ferredoxin + NADPH
show the reaction diagram
reduced flavodoxin + NADP+
oxidized flavodoxin + NADPH
show the reaction diagram
[4Fe-4S]-ferredoxin + NADPH
reduced [4Fe-4S]-ferredoxin + NADP+
show the reaction diagram
-
[4Fe-4S]-ferredoxin of Pseudomonas putida is similar to ferredoxin FdI of Azotobacter vinelandii, the Pseudomonas putida chromosome contains two [2Fe-2S] ferredoxins (FdA and FdB), three [4Fe-4S] ferredoxins (4FdA, 4FdB and FdxA) and one flavodoxin (Fld)
-
-
r
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2Fe-2S-center
-
-
Ferredoxin
flavin
NAD(P)H
-
NADPH is absolutely preferred over NADH by the wild-type isozymes
additional information