Reference on EC 1.14.19.1 - stearoyl-CoA 9-desaturase and Organism(s) Mus musculus and UniProt Accession P13011
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Miyazaki, M.; Kim, H.J.; Man, W.C.; Ntambi, J.M.
Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol
J. Biol. Chem.
276
39455-39461
2001
Mus musculus
Miyazaki, M.; Jacobson, M.J.; Man, W.C.; Cohen, P.; Asilmaz, E.; Friedman, J.M.; Ntambi, J.M.
Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
J. Biol. Chem.
278
33904-33911
2003
Mus musculus (P13011), Mus musculus
Jiang, G.; Li, Z.; Liu, F.; Ellsworth, K.; Dallas-Yang, Q.; Wu, M.; Ronan, J.; Esau, C.; Murphy, C.; Szalkowski, D.; Bergeron, R.; Doebber, T.; Zhang, B.B.
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1
J. Clin. Invest.
115
1030-1038
2005
Mus musculus
Biddinger, S.B.; Almind, K.; Miyazaki, M.; Kokkotou, E.; Ntambi, J.M.; Kahn, C.R.
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome
Diabetes
54
1314-1323
2005
Mus musculus
Biddinger, S.B.; Miyazaki, M.; Boucher, J.; Ntambi, J.M.; Kahn, C.R.
Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
Diabetes
55
2032-2041
2006
Mus musculus
Dobrzyn, P.; Dobrzyn, A.
Stearoyl-CoA desaturase: a new therapeutic target of liver steatosis
Drug Develop. Res.
67
643-650
2006
Mus musculus (P13011), Mus musculus (P13516), Mus musculus (Q6T707), Mus musculus (Q99PL7)
-
Mutch, D.M.; Grigorov, M.; Berger, A.; Fay, L.B.; Roberts, M.A.; Watkins, S.M.; Williamson, G.; German, J.B.
An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet
FASEB J.
19
599-601
2005
Mus musculus (P13011), Mus musculus (P13516), Mus musculus (Q99PL7), Mus musculus, Mus musculus Rj:NMRI (P13011), Mus musculus Rj:NMRI (P13516), Mus musculus Rj:NMRI (Q99PL7)
Man, W.C.; Miyazaki, M.; Chu, K.; Ntambi, J.M.
Membrane topology of mouse stearoyl-CoA desaturase 1
J. Biol. Chem.
281
1251-1260
2006
Mus musculus
Sampath, H.; Miyazaki, M.; Dobrzyn, A.; Ntambi, J.M.
Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat
J. Biol. Chem.
282
2483-2493
2007
Mus musculus
Flowers, M.T.; Miyazaki, M.; Liu, X.; Ntambi, J.M.
Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance
J. Clin. Invest.
116
1478-1481
2006
Mus musculus
Gutierrez-Juarez, R.; Pocai, A.; Mulas, C.; Ono, H.; Bhanot, S.; Monia, B.P.; Rossetti, L.
Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
J. Clin. Invest.
116
1686-1695
2006
Mus musculus, Rattus norvegicus, Mus musculus C57/BL6J
Dobrzyn, A.; Dobrzyn, P.
Stearoyl-CoA desaturase - a new player in skeletal muscle metabolism regulation
J. Physiol. Pharmacol.
57 Suppl 10
31-42
2006
Mus musculus, Rattus norvegicus, Sus scrofa
Dobrzyn, A.; Ntambi, J.M.
Stearoyl-CoA desaturase as a new drug target for obesity treatment
Obes. Rev.
6
169-174
2005
Mus musculus
Dobrzyn, P.; Sampath, H.; Dobrzyn, A.; Miyazaki, M.; Ntambi, J.M.
Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart
Am. J. Physiol. Endocrinol. Metab.
294
E357-E364
2008
Mus musculus
Xin, Z.; Zhao, H.; Serby, M.D.; Liu, B.; Liu, M.; Szczepankiewicz, B.G.; Nelson, L.T.; Smith, H.T.; Suhar, T.S.; Janis, R.S.; Cao, N.; Camp, H.S.; Collins, C.A.; Sham, H.L.; Surowy, T.K.; Liu, G.
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors
Bioorg. Med. Chem. Lett.
18
4298-4302
2008
Homo sapiens, Mus musculus
Christianson, J.L.; Nicoloro, S.; Straubhaar, J.; Czech, M.P.
Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells
J. Biol. Chem.
283
2906-2916
2008
Mus musculus
Liu, G.; Lynch, J.K.; Freeman, J.; Liu, B.; Xin, Z.; Zhao, H.; Serby, M.D.; Kym, P.R.; Suhar, T.S.; Smith, H.T.; Cao, N.; Yang, R.; Janis, R.S.; Krauser, J.A.; Cepa, S.P.; Beno, D.W.; Sham, H.L.; Collins, C.A.; Surowy, T.K.; Camp, H.S.
Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors
J. Med. Chem.
50
3086-3100
2007
Homo sapiens, Mus musculus
Paton, C.M.; Ntambi, J.M.
Biochemical and physiological function of stearoyl-CoA desaturase
Am. J. Physiol. Endocrinol. Metab.
297
E28-E37
2009
Mus musculus
Macdonald, M.L.; Bissada, N.; Vallance, B.A.; Hayden, M.R.
Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis
Biochim. Biophys. Acta
1791
1166-1172
2009
Mus musculus
Flowers, M.T.; Ntambi, J.M.
Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity
Biochim. Biophys. Acta
1791
85-91
2009
Mus musculus
Uto, Y.; Ogata, T.; Harada, J.; Kiyotsuka, Y.; Ueno, Y.; Miyazawa, Y.; Kurata, H.; Deguchi, T.; Watanabe, N.; Takagi, T.; Wakimoto, S.; Okuyama, R.; Abe, M.; Kurikawa, N.; Kawamura, S.; Yamato, M.; Osumi, J.
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
Bioorg. Med. Chem. Lett.
19
4151-4158
2009
Homo sapiens, Mus musculus
Uto, Y.; Ogata, T.; Kiyotsuka, Y.; Miyazawa, Y.; Ueno, Y.; Kurata, H.; Deguchi, T.; Yamada, M.; Watanabe, N.; Takagi, T.; Wakimoto, S.; Okuyama, R.; Konishi, M.; Kurikawa, N.; Kono, K.; Osumi, J.
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation
Bioorg. Med. Chem. Lett.
19
4159-4166
2009
Homo sapiens, Mus musculus
Uto, Y.; Ogata, T.; Kiyotsuka, Y.; Ueno, Y.; Miyazawa, Y.; Kurata, H.; Deguchi, T.; Watanabe, N.; Konishi, M.; Okuyama, R.; Kurikawa, N.; Takagi, T.; Wakimoto, S.; Ohsumi, J.
Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats
Bioorg. Med. Chem. Lett.
20
341-345
2010
Homo sapiens, Mus musculus
Chen, C.; Shah, Y.M.; Morimura, K.; Krausz, K.W.; Miyazaki, M.; Richardson, T.A.; Morgan, E.T.; Ntambi, J.M.; Idle, J.R.; Gonzalez, F.J.
Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis
Cell Metab.
7
135-147
2008
Mus musculus
Sampath, H.; Flowers, M.T.; Liu, X.; Paton, C.M.; Sullivan, R.; Chu, K.; Zhao, M.; Ntambi, J.M.
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
J. Biol. Chem.
284
19961-19973
2009
Mus musculus
Li, Z.Z.; Berk, M.; McIntyre, T.M.; Feldstein, A.E.
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase
J. Biol. Chem.
284
5637-5644
2009
Mus musculus
Stamatikos, A.D.; Paton, C.M.
Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism
Am. J. Physiol. Endocrinol. Metab.
305
E767-E775
2013
Mus musculus
Yokoyama, S.; Hosoi, T.; Ozawa, K.
Stearoyl-CoA desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice
Gene
497
340-343
2012
Mus musculus
Sampath, H.; Ntambi, J.M.
The role of Stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance
J. Biol. Chem.
289
2482-2488
2014
Mus musculus
Koeberle, A.; Loeser, K.; Thuermer, M.
Stearoyl-CoA desaturase-1 and adaptive stress signaling
Biochim. Biophys. Acta
1861
1719-1726
2016
Homo sapiens (O00767), Mus musculus (P13516)
Sun, S.; Zhang, Z.; Pokrovskaia, N.; Chowdhury, S.; Jia, Q.; Chang, E.; Khakh, K.; Kwan, R.; McLaren, D.G.; Radomski, C.C.; Ratkay, L.G.; Fu, J.; Dales, N.A.; Winther, M.D.
Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors
Bioorg. Med. Chem.
23
455-465
2015
Homo sapiens (O00767), Mus musculus (P13516)
Iwai, T.; Kume, S.; Chin-Kanasaki, M.; Kuwagata, S.; Araki, H.; Takeda, N.; Sugaya, T.; Uzu, T.; Maegawa, H.; Araki, S.I.
Stearoyl-CoA desaturase-1 protects cells against lipotoxicity-mediated apoptosis in proximal tubular cells
Int. J. Mol. Sci.
17
E1868
2016
Mus musculus (P13516)
Bai, Y.; McCoy, J.G.; Levin, E.J.; Sobrado, P.; Rajashankar, K.R.; Fox, B.G.; Zhou, M.
X-ray structure of a mammalian stearoyl-CoA desaturase
Nature
524
252-256
2015
Mus musculus (P13516), Mus musculus (Q99PL7), Mus musculus
Rodriguez-Cuenca, S.; Whyte, L.; Hagen, R.; Vidal-Puig, A.; Fuller, M.
Stearoyl-CoA desaturase 1 Is a key determinant of membrane lipid composition in 3T3-L1 adipocytes
PLoS ONE
11
e0162047
2016
Mus musculus (P13516)
ALJohani, A.M.; Syed, D.N.; Ntambi, J.M.
Insights into stearoyl-CoA desaturase-1 regulation of systemic metabolism
Trends Endocrinol. Metab.
28
831-842
2017
Homo sapiens (O00767), Homo sapiens (Q86SK9), Mus musculus (P13011), Mus musculus (P13516), Mus musculus (Q8BNZ5), Mus musculus (Q8CFY4)
