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Literature summary for 1.14.19.1 extracted from

  • Paton, C.M.; Ntambi, J.M.
    Biochemical and physiological function of stearoyl-CoA desaturase (2009), Am. J. Physiol. Endocrinol. Metab., 297, E28-E37.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.1

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for activity Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain isoform SCD-2 is predominantly expressed in brain Mus musculus
-
brown adipose tissue isoform SCD-1 Mus musculus
-
hair follicle isoform SCD-2 Mus musculus
-
harderian gland isoform SCD-1 Mus musculus
-
heart isoforms SCD-1 and SCD-4 Mus musculus
-
kidney isoforms SCD-1 and SCD-2 Mus musculus
-
liver isoform SCD-1 Mus musculus
-
lung isoforms SCD-1 and SCD-2 Mus musculus
-
meibomian gland isoform SCD-1 Mus musculus
-
preputial gland isoform SCD-1 Mus musculus
-
sebocyte isoform SCD-1 Mus musculus
-
skin isoforms SCD-1, SCD-2, and SCD-3 Mus musculus
-
spleen isoforms SCD-1 and SCD-2 Mus musculus
-
white adipose tissue isoform SCD-1 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + ferrocytochrome b5 + O2
-
 Mus musculus palmitoleoyl-CoA + ferricytochrome b5 + H2O
-
 ?
stearoyl-CoA + ferrocytochrome b5 + O2
-
 Mus musculus oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?
stearoyl-CoA + NADH + H+ + O2
-
 Mus musculus oleoyl-CoA + NAD+ + H2O
-
 ?
stearoyl-CoA + NADPH + H+ + O2
-
 Mus musculus oleoyl-CoA + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
SCD-1 isoform Mus musculus
SCD-2 isoform Mus musculus
SCD-3 isoform Mus musculus
SCD-4 isoform Mus musculus
stearoyl-CoA desaturase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Mus musculus
NADH
-
 Mus musculus
NADPH
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus isoform SCD-1 expression is dramatically induced in liver and heart in response to high-carbohydrate diet, SCD-1 expression is also induced by nuclear sterol regulatory element-binding protein-1 via the sterol regulatory element in its promoter, in aortic endothelial cells liver X receptor beta activation increases SCD-1 mRNA and protein expression up

General Information

General Information Comment Organism
metabolism SCD is critical in the biosynthesis of triglycerides, cholesterol esters, wax esters, and 1-alkyl-2,3-diacylglycerol Mus musculus
physiological function SCD-1 knockout mice show reduced body adiposity, increased insulin sensitivity, leanness, increased metabolic rate, and resistance to diet-induced obesity Mus musculus