Cloned (Comment) | Organism |
---|---|
overexpression in CHO cells results in a significant increase in the rate of triglyceride synthesis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | leptin-deficient obese ob/ob mice lacking SCD1 showed markedly reduced adiposity, despite higher food intake | Mus musculus |
additional information | mice with targeted disruption in the SCD1 gene have increased energy expenditure, reduced body adiposity, increased insulin sensitivity and are resistant to diet-induced obesity | Mus musculus |
additional information | SCD1 -/- mice have a decrease in cellular levels of malonyl-CoA in the liver | Mus musculus |
additional information | SCD1 deficiency attenuates fasting-induced liver steatosis in peroxisome proliferator-activated receptor alpha-deficient mice | Mus musculus |
additional information | SCD1 deficiency corrects the hypometabolic phenotype and hepatic steatosis of ob/ob mice | Mus musculus |
additional information | SCD1 deficiency increases the rate of beta-oxidation in liver, skeletal muscle and brown adipose tissue | Mus musculus |
additional information | SCD1-deficient mice show significantly higher total and resting oxygen consumption than littermate controls | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of SCD1 leads to reduction in lipid accumulation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P13011 | - |
- |
Mus musculus | P13516 | - |
- |
Mus musculus | Q6T707 | - |
- |
Mus musculus | Q99PL7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | SCD1 isoform | Mus musculus | - |
harderian gland | SCD3 isoform | Mus musculus | - |
heart | SCD4 isoform | Mus musculus | - |
liver | SCD1 isoform | Mus musculus | - |
liver | SCD2 isoform only in early stages | Mus musculus | - |
additional information | SCD2 isoform is ubiquitously expressed in most tissues except liver | Mus musculus | - |
preputial gland | SCD3 isoform | Mus musculus | - |
skin | sebocytes, SCD3 isoform | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
fasting reduces hepatic SCD1 protein expression and activity, and refeeding a high-carbohydrate or a high-sucrose diet increases both | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
SCD1 | - |
Mus musculus |
SCD2 | - |
Mus musculus |
SCD3 | - |
Mus musculus |
SCD4 | - |
Mus musculus |