6.3.4.14: biotin carboxylase
This is an abbreviated version!
For detailed information about biotin carboxylase, go to the full flat file.
Word Map on EC 6.3.4.14
-
6.3.4.14
-
carboxyltransferase
-
carboxylases
-
biotin-dependent
-
malonyl-coa
-
acetyl-coenzyme
-
propionyl-coa
-
carboxybiotin
-
6.4.1.2
-
biotin-carboxyl
-
biotin-containing
-
bicarbonate-dependent
-
biotin-binding
-
carboxyphosphate
-
transcarboxylase
-
mgatp-dependent
-
accases
-
atp-grasp
-
medicine
- 6.3.4.14
- carboxyltransferase
- carboxylases
-
biotin-dependent
- malonyl-coa
-
acetyl-coenzyme
- propionyl-coa
- carboxybiotin
-
6.4.1.2
-
biotin-carboxyl
-
biotin-containing
-
bicarbonate-dependent
-
biotin-binding
- carboxyphosphate
- transcarboxylase
-
mgatp-dependent
- accases
-
atp-grasp
- medicine
Reaction
Synonyms
ACC, AccA, AccBC, AccC, BC, biotin carboxylase, biotin carboxylase (component of acetyl CoA carboxylase), biotinoyl domain of acetyl-CoA carboxylase, BirA, Carboxylase, biotin, More, PC-beta
ECTree
6.3.4.14 biotin carboxylaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 6.3.4.14 - biotin carboxylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate
ATP + 1'-N-carboxy-D-biotin + HCO3-
ADP + phosphate + ?
-
the 1'-ureido-N position of biotin is the enzymatic site of carboxylation
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
ATP + biotin-carboxyl-carrier protein + HCO3-
?
-
the acetyl-CoA carboxylase catalyzes the first commited step in the biosynthesis of long chain fatty acids, the acetyl-CoA carboxylase system is composed of 3 components: 1. biotin carboxylase, 2. carboxyltransferase, 3. carboxylcarrier protein
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
ATP + d-biotin + HCO3-
ADP + phosphate + carboxy-d-biotin
-
BC component of the multisubunit complex of acetyl-CoA carboxylase
-
-
?
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate
ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
GTP + biotin-carboxyl-carrier protein + HCO3-
GDP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ADP + carbamoyl phosphate
ATP + carbamate
-
biotin carboxylase catalyzes an ATP synthesis reaction, in which a phosphate group is transferred from carbamoyl phosphate to ADP forming ATP and carbamate
carbamate rapidly decomposes into carbon dioxide and ammonia
-
?
ADP + carbamoyl phosphate
ATP + carbamate
-
biotin carboxylase catalyzes the formation of ATP from ADP and carbamoyl phosphate
-
-
r
ADP + carbamoyl phosphate
ATP + carbamate
-
biotin carboxylase catalyzes an ATP synthesis reaction, in which a phosphate group is transferred from carbamoyl phosphate to ADP forming ATP and carbamate
carbamate rapidly decomposes into carbon dioxide and ammonia
-
?
ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate
-
ADP in form of MgADP-
-
-
r
ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate
-
ADP in form of MnADP-
-
-
r
ATP + biotin + HCO3-
ADP + phosphate + carboxybiotin
-
also uses free biotin as substrate
-
-
?
ATP + biotin + HCO3-
ADP + phosphate + carboxybiotin
-
also utilizes free biotin as substrate
-
-
?
ATP + biotin + HCO3-
ADP + phosphate + carboxybiotin
-
biotin carboxylase component of the multienzyme complex acetyl-CoA carboxylase, also utilizes free biotin as substrate
-
-
?
ATP + biotin + HCO3-
ADP + phosphate + carboxybiotin
-
free biotin, 8000fold lower activity than with the C-terminal 87 amino acids of the biotinylated biotin-carboxyl-carrier protein, biotin carboxylase activity of acetyl-CoA carboxylase
-
-
?
ATP + biotin + HCO3-
ADP + phosphate + carboxybiotin
-
utilizes free biotin as substrate
-
-
?
ATP + biotin + HCO3-
ADP + phosphate + carboxybiotin
-
utilizes free biotin as substrate
-
-
r
ATP + biotin + HCO3-
ADP + phosphate + carboxybiotin
-
utilizes free biotin as substrate in vitro
-
-
?
ATP + biotin + HCO3-
ADP + phosphate + carboxybiotin
-
ATP in form of MgATP2-
-
-
?
ATP + biotin + HCO3-
ADP + phosphate + carboxybiotin
-
utilizes free biotin as substrate
-
-
?
ATP + biotin + HCO3-
ADP + phosphate + carboxybiotin
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
mathematical modeling and numerical simulations of the kinetics of wild-type, hybrid dimers, and mutant homodimers of biotin carboxylase are performed. Numerical simulations of biotin carboxylase kinetics are the most similar to the experimental data when an oscillating active site model is used. In contrast, alternative models where the active sites are independent do not agree with the experimental data. Thus, the numerical simulations of the proposed kinetic model support the hypothesis that the two active sites of biotin carboxylase alternate their catalytic cycles
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
biotin carboxylase catalyzes the ATP-dependent carboxylation of biotin and is one component of the multienzyme complex acetyl-CoA carboxylase that catalyzes the first committed step in fatty acid synthesis
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
in Gram-negative and Gram-positive bacteria biotin carboxylase, carboxyltransferase, and the biotin carboxyl carrier protein are separate proteins
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
the biotinoyl domain interacts with the biotin-carboxyl-carrier protein, BCCP, biotin must be attached to ACC to produce a functional enzyme
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
Geotalea uraniireducens
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
The overall acetyl-CoA carboxylase, ACC, reaction proceeds by a two-step mechanism. The first half-reaction is carried out by the biotin carboxylase and involves the ATP-dependent carboxylation of biotin, in which bicarbonate serves as the CO2 source. The carboxyl transferase catalyzes the second half-reaction in which the carboxyl group is transferred from biotin to acetyl-CoA to produce malonyl-CoA, the biotinoyl domain performs a critical function by transferring the activated carboxyl group from the biotin carboxylase domain to the carboxyl transferase domain, overview
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
biotin is covalently attached to a protein called the biotin-carboxyl-carrier protein. In mammals, these proteins comprise different domains in a single polypeptide chain, biotin must be attached to ACC to produce a functional enzyme
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
BC subunit of pyruvate carboxylase, BC/active site structure
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
biosynthesis of long-chain fatty acids, in vivo biotin is attached to the carboxyl-carrier protein through an amide bond to a specific lysine residue
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
biotin carboxylase catalyzes the first half-reaction in the first committed step in long chain fatty acid biosynthesis, catalyzed by acetyl-CoA carboxylase
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
first half reaction of the first committed step in the biosynthesis of long-chain fatty acids, in vivo the biotin substrate is attached to biotin-carboxyl-carrier protein, natural substrate
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
long-chain fatty acid synthesis, in vivo biotin is covalently attached to the biotin-carboxyl-carrier protein
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
long-chain fatty acid synthesis, in vivo biotin is linked to the biotin-carboxyl-carrier protein through an amide bond to a specific lysine residue
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
one component of the multienzyme complex acetyl-CoA carboxylase, catalyzes the ATP-dependent carboxylation of biotin, which is covalently attached to the biotin-carboxyl-carrier protein in vivo, fatty acid synthesis
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
ATP-dependent carboxylation of biotin using bicarbonate as the carboxylate source, component of the multifunctional acetyl-CoA carboxylase, roles of Arg-338 and Lys-238 in the carboxyl transfer to biotin, Arg-338 serves to orient the carboxyphosphate intermediate for optimal carboxylation of biotin
-
-
r
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
biotin carboxylase component of the multienzyme complex acetyl-CoA carboxylase, catalyzes the first half-reaction of the reaction catalyzed by acetyl-CoA carboxylase, the ATP-dependent carboxylation of biotin, ordered addition of substrates with ATP binding first followed by bicarbonate and then biotin
-
-
r
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
biotin carboxylase is one of three distinct components of acetyl-CoA carboxylase, carboxylation of the ureido ring of biotin at the N-1 position, reaction mechanism, domain structure, the biotin carboxylase B-domain moves as a result of ATP binding, enzyme structure
-
-
r
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
Lys-238 interacts with the gamma-phosphate group of ATP but is not involved in catalysis, BC is a subunit of acetyl-CoA carboxylase and mediates the carboxylation of enzyme-bound biotin
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
one component of the multienzyme complex acetyl-CoA carboxylase, catalyzes the ATP-dependent carboxylation of biotin, active site structure, binding of biotin accelerates the rate of ATP hydrolysis about 1100fold: substrate-induced synergism
-
-
r
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
one component of the multienzyme complex acetyl-CoA carboxylase, catalyzes the ATP-dependent carboxylation of biotin, for that biotin must be deprotonated at its N1 position, mechanism for deprotonation of biotin, bicarbonate is the source of CO2, Lys-238 plays a role in the carboxylation reaction, Cys-230 and Lys-238 do not act as an acid-base pair in the deprotonation of biotin, but may be involved in ATP binding
-
-
r
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
one component of the multienzyme complex acetyl-CoA carboxylase, catalyzes the ATP-dependent carboxylation of biotin, two complete active sites per homodimer
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
the biotin carboxylase component of acetyl-CoA carboxylase catalyzes the ATP-dependent carboxylation of biotin using bicarbonate as the carboxylate source, Lys-116, Lys-159, His-209 and Glu-276 are involved in ATP binding and in catalysis orienting ATP in a conformation that allows for optimal catalysis, mechanism
-
-
r
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
the biotin carboxylase component of acetyl-CoA carboxylase catalyzes the first half-reaction of the reaction catalyzed by acetyl-CoA carboxylase, the half-reaction involves the phosphorylation of bicarbonate by ATP to form a carboxyphosphate intermediate, followed by transfer of the carboxyl group to biotin to form carboxybiotin, in vivo biotin is attached to biotin-carboxyl-carrier protein, the C-terminal 87 amino acids of the biotinylated biotin-carboxyl-carrier protein form a domain that acts as excellent substrate
-
-
r
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
Escherichia coli B / ATCC 11303
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
biosynthesis of long-chain fatty acids, in vivo biotin is attached to the carboxyl-carrier protein through an amide bond to a specific lysine residue
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
one component of the multienzyme complex acetyl-CoA carboxylase, catalyzes the ATP-dependent carboxylation of biotin, active site structure, binding of biotin accelerates the rate of ATP hydrolysis about 1100fold: substrate-induced synergism
-
-
r
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
biotin carboxylase subunit AccA of acetyl-CoA carboxylase
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
Myxococcus xanthus IFO13542 / ATCC 25232
biotin carboxylase subunit AccA of acetyl-CoA carboxylase
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
BC component of the multisubunit complex acetyl-CoA carboxylase, BC catalyzes the ATP-dependent carboxylation of the biotinyl moiety on biotin carboxyl carrier protein
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + biotin-carboxyl-carrier protein + HCO3-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
-
-
?
ATP + D-(+)-biotin + HCO3-
ADP + phosphate + carboxybiotin
-
sequential mechanism, in which HCO3- is activated by ATP in a first step
-
-
?
ATP + D-(+)-biotin + HCO3-
ADP + phosphate + carboxybiotin
-
L-biotin is completely inactive
-
?
ATP + D-(+)-biotin + HCO3-
ADP + phosphate + carboxybiotin
-
L-biotin is completely inactive
-
-
?
ATP + D-(+)-biotin + HCO3-
ADP + phosphate + carboxybiotin
Escherichia coli B / ATCC 11303
-
L-biotin is completely inactive
-
-
?
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate
ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
-
ATP in form of MnATP2-
-
-
r
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate
ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
-
ATP in form of MgATP2-
-
-
r
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate
ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine
-
ATP in form of CoATP2-
-
-
r
additional information
?
-
the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
-
-
?
additional information
?
-
-
BC subunit of pyruvate carboxylase, which is involved in gluconeogenesis
-
-
?
additional information
?
-
the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
-
-
?
additional information
?
-
-
the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
-
-
?
additional information
?
-
-
the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
-
-
?
additional information
?
-
the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
-
-
?
additional information
?
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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additional information
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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additional information
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enzyme catalyzes ATP-hydrolysis in absence of biotin
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additional information
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enzyme catalyzes ATP-hydrolysis in absence of biotin
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additional information
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biotin carboxylase catalyzes a slow bicarbonate-dependent ATP hydrolysis reaction in the absence of biotin
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additional information
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in absence of biotin enzyme also catalyzes a slow bicarbonate-dependent ATP hydrolysis
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additional information
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in the absence of biotin biotin carboxylase catalyzes a bicarbonate-dependent ATP hydrolysis at a slow rate
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additional information
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in the absence of biotin biotin carboxylase catalyzes a bicarbonate-dependent ATPase reaction at a 1100fold slower rate than in the presence of biotin
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additional information
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the reaction mechanism of the acetyl-CoA carboxylase proceeds via two half-reactions: the first half-reaction is catalyzed by biotin carboxylase, the second half-reaction is catalyzed by carboxyltransferase
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additional information
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the reaction mechanism of the acetyl-CoA carboxylase proceeds via two half-reactions: the first half-reaction is catalyzed by biotin carboxylase, the second half-reaction is catalyzed by carboxyltransferase
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additional information
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active site structure, substrate binding and structure-function relationship analysis, overview
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additional information
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mechanism of ACC holoenzyme function, structure of the biotinoyl domain, overview. In thei BCCP, Glu 119 and Glu147 interact with the basic residues in BirA, overview
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additional information
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molecular dynamics simulations of wild-type enzyme and active-site mutant E288K, overview
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additional information
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molecular dynamics simulations of wild-type enzyme and active-site mutant E288K, overview
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additional information
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in the absence of biotin biotin carboxylase catalyzes a bicarbonate-dependent ATPase reaction at a 1100fold slower rate than in the presence of biotin
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additional information
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Geotalea uraniireducens
the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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additional information
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during the catalytic mechanism, the binding pocket that binds tetrahedral phosphate also accommodates and stabilizes a tetrahedral dianionic transition state resulting from direct transfer of CO2 from the carboxyphosphate intermediate to biotin
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additional information
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during the catalytic mechanism, the binding pocket that binds tetrahedral phosphate also accommodates and stabilizes a tetrahedral dianionic transition state resulting from direct transfer of CO2 from the carboxyphosphate intermediate to biotin
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additional information
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during the catalytic mechanism, the binding pocket that binds tetrahedral phosphate also accommodates and stabilizes a tetrahedral dianionic transition state resulting from direct transfer of CO2 from the carboxyphosphate intermediate to biotin
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additional information
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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additional information
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mechanism of ACC holoenzyme function, structure of the biotinoyl domain of isozyme ACC2, overview
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additional information
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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additional information
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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?
additional information
?
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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?
additional information
?
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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?
additional information
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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additional information
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AccA is a biotinylated protein mainly expressed in the exponential growth phase
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additional information
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AccA is a biotinylated protein mainly expressed in the exponential growth phase
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additional information
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Myxococcus xanthus IFO13542 / ATCC 25232
AccA is a biotinylated protein mainly expressed in the exponential growth phase
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additional information
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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additional information
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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additional information
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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additional information
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pathway from acetyl-CoA to long-chain fatty acids, developmental regulation of enzyme
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additional information
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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additional information
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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?
additional information
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active site structure, substrate binding and structure-function relationship analysis, overview
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?
additional information
?
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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?
additional information
?
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active site structure, substrate binding and structure-function relationship analysis, overview
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?
additional information
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active site structure, substrate binding and structure-function relationship analysis, overview
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?
additional information
?
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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?
additional information
?
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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?
additional information
?
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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?
additional information
?
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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?
additional information
?
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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?
additional information
?
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the biotin carboxylase is a subunit of the acetyl CoA carboxylase, ACCase
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