6.3.4.14: biotin carboxylase
This is an abbreviated version!
For detailed information about biotin carboxylase, go to the full flat file.
Word Map on EC 6.3.4.14
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6.3.4.14
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carboxyltransferase
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carboxylases
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biotin-dependent
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malonyl-coa
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acetyl-coenzyme
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propionyl-coa
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carboxybiotin
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6.4.1.2
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biotin-carboxyl
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biotin-containing
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bicarbonate-dependent
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biotin-binding
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carboxyphosphate
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transcarboxylase
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mgatp-dependent
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accases
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atp-grasp
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medicine
- 6.3.4.14
- carboxyltransferase
- carboxylases
-
biotin-dependent
- malonyl-coa
-
acetyl-coenzyme
- propionyl-coa
- carboxybiotin
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6.4.1.2
-
biotin-carboxyl
-
biotin-containing
-
bicarbonate-dependent
-
biotin-binding
- carboxyphosphate
- transcarboxylase
-
mgatp-dependent
- accases
-
atp-grasp
- medicine
Reaction
Synonyms
ACC, AccA, AccBC, AccC, BC, biotin carboxylase, biotin carboxylase (component of acetyl CoA carboxylase), biotinoyl domain of acetyl-CoA carboxylase, BirA, Carboxylase, biotin, More, PC-beta
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Activating Compound
Activating Compound on EC 6.3.4.14 - biotin carboxylase
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acetyl-CoA
allosteric activator of holoenzyme. Acetyl-CoA promotes a conformation for the dimer of the biotin carboxylase domain of pyruvate carboxylase that might be catalytically more competent
cyclophilin
cyclophilin stimulates the ATP hydrolysis activity of the enzyme (8fold stimulation of activity at 10fold molar excess over the enzyme)
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activates the ATP synthesis reaction with ADP and carbamoyl phosphate as substrates
biotin
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required for activation of the ATP synthesis reaction with carbamoyl phosphate and ADP as substrates, E211, E288, N290 and R292 are responsible, at least in part, for the substrate-induced synergism by biotin, activation via a conformational change of enzyme
biotin
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substrate-induced synergism, the reaction in presence of biotin is 1100fold faster than in its absence
biotin
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substrate induced synergism, the reaction inpresence of biotin is 1100fold faster than in its absence
biotin
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substrate-induced synergism, the reaction in presence of biotin is 1100fold faster than in its absence