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6.3.2.1: pantoate-beta-alanine ligase (AMP-forming)

This is an abbreviated version!
For detailed information about pantoate-beta-alanine ligase (AMP-forming), go to the full flat file.

Word Map on EC 6.3.2.1

Reaction

ATP
+
(R)-pantoate
 +
beta-Alanine
=
AMP
 +
diphosphate
 +
(R)-pantothenate

Synonyms

D-Pantoate:beta-alanine ligase (AMP-forming), MTBPS, PanC, panthotenate synthetase, Pantoate activating enzyme, pantoate-beta-alanine ligase, Pantoic-activating enzyme, pantothenate, Pantothenate synthetase, PS, PTS, Rv3602c, synthetase, Synthetase, pantothenate

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.1 pantoate-beta-alanine ligase (AMP-forming)

KI Value

KI Value on EC 6.3.2.1 - pantoate-beta-alanine ligase (AMP-forming)

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0008
(2RS)-5'-O-(2-hydroxy-4-methoxybutyrylsulfamoyl) adenosine
25°C
0.065 - 0.25
(2RS)-5'-O-(3,3-dimethyl-2-aminobutyrylsulfamoyl)adenosine
0.03 - 0.144
(2RS)-5'-O-(3,3-dimethyl-2-hydroxy-4-methoxybutyrylsulfamoyl)adenosine
0.0003 - 0.0011
(2RS)-5'-O-(3,3-dimethyl-2-hydroxybutyrylsulfamoyl)adenosine
0.014 - 0.12
(2RS)-5'-O-(3,3-dimethyl-2-oxobutyrylsulfamoyl)adenosine
2.5
(2RS)-adenosyl-2-hydroxy-3,3-dimethylbuyrate
25°C
3.5
(2RS)-adenosyl-2-hydroxy-4-methoxybutyrate
25°C
18.2
(2RS)-adenosyl-3,3-dimethyl-2-hydroxy-4-methoxybutyrate
25°C
9.5
(2S)-adenosyl-2-L-amino-3,3-dimethylbutanoate
25°C
1.9
3,3-dimethyl-2-oxobutyric acid 5-(6-aminopurin-9-yl)-3,4-dihydroxytetrahydrofuran-2-ylmethyl ester
25°C
0.000174
3-(biphenyl-4-yl)-4-cyano-5-(ethylsulfanyl)-1-methyl-1H-pyrrole-2-carboxylic acid
versus pantoate, pH 7.8, 37°C
0.000297
4-cyano-3-(4'-cyanobiphenyl-4-yl)-1-methyl-5-propyl-1H-pyrrole-2-carboxylic acid
versus pantoate, pH 7.8, 37°C
0.00009
5-tert-butyl-N-[1-(naphthalen-1-ylmethyl)-1H-pyrazol-4-yl]-4,5,6,7-tetrahydro-1,2-benzoxazole-3-carboxamide
pH and temperature not specified in the publication
0.0224
methyl 5-amino-3-(benzyloxy)-1H-indole-2-carboxylate
pH and temperature not specified in the publication
0.075
nafronyl oxalate
-
-
4.5 - 7.6
pantothenate
0.0018
[2-[(1-benzofuran-2-ylsulfonyl)carbamoyl]-5-methyl-1H-inden-1-yl]acetic acid
pH and temperature not specified in the publication