6.3.2.1: pantoate-beta-alanine ligase (AMP-forming)
This is an abbreviated version!
For detailed information about pantoate-beta-alanine ligase (AMP-forming), go to the full flat file.
Word Map on EC 6.3.2.1
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6.3.2.1
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trna
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aminoacyl-trna
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aminoacylation
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coa
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glycogen
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thromboxane
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prostaglandin
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adenylate
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carboxylase
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gsh
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neurodegeneration
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nonribosomal
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acyl-coa
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carbamyl
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anticodon
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phosphorylase
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ribonucleic
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polyketide
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polyadp-ribose
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kinase-associated
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arachidonic
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purine
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ornithine
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lipogenic
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multienzyme
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lipogenesis
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indomethacin
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adp-ribose
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palmitoyl-coa
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argininosuccinate
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lipopeptide
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tx
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transcarbamylase
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acyl-coenzyme
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ifn-alpha
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thioesterase
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3-aminobenzamide
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microcystins
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cyclooxygenase
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myositis
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dermatomyositis
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interferon-induced
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dystonia
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ifn-induced
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malonyl-coa
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amber
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ifn-beta
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polymyositis
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delta-aminolevulinic
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drug development
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6-keto-pgf1
- 6.3.2.1
- trna
- aminoacyl-trna
- aminoacylation
- coa
- glycogen
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thromboxane
- prostaglandin
- adenylate
- carboxylase
- gsh
- neurodegeneration
-
nonribosomal
- acyl-coa
-
carbamyl
-
anticodon
- phosphorylase
-
ribonucleic
- polyketide
-
polyadp-ribose
-
kinase-associated
-
arachidonic
- purine
- ornithine
-
lipogenic
-
multienzyme
-
lipogenesis
- indomethacin
- adp-ribose
- palmitoyl-coa
- argininosuccinate
-
lipopeptide
- tx
-
transcarbamylase
-
acyl-coenzyme
- ifn-alpha
-
thioesterase
- 3-aminobenzamide
- microcystins
-
cyclooxygenase
- myositis
- dermatomyositis
-
interferon-induced
- dystonia
-
ifn-induced
- malonyl-coa
-
amber
-
ifn-beta
- polymyositis
-
delta-aminolevulinic
- drug development
-
6-keto-pgf1
Reaction
Synonyms
D-Pantoate:beta-alanine ligase (AMP-forming), MTBPS, PanC, panthotenate synthetase, Pantoate activating enzyme, pantoate-beta-alanine ligase, Pantoic-activating enzyme, pantothenate, Pantothenate synthetase, PS, PTS, Rv3602c, synthetase, Synthetase, pantothenate
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Reaction
Reaction on EC 6.3.2.1 - pantoate-beta-alanine ligase (AMP-forming)
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bi uni uni bi ping pong mechanism
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ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
the enzyme catalyzes the ATP-dependent condensation of pantoate with beta-alanine via a pantoyl adenylate intermediate and follows a bi uni uni bi ping pong kinetic mechanism. The Mg2+ dependent reaction involves two sequential steps. Initially binding of ATP with pantoate, leads to formation of pantoyl adenylate and release of diphosphate. Second step involves nucleophilic attack by beta-alanine on the active carbonyl group of pantoyl adenylate and subsequent release of AMP and pantothenate
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
the enzyme catalyzes the ATP-dependent condensation of pantoate with beta-alanine via a pantoyl adenylate intermediate and follows a bi uni uni bi ping pong kinetic mechanism. The Mg2+ dependent reaction involves two sequential steps. Initially binding of ATP with pantoate, leads to formation of pantoyl adenylate and release of diphosphate. Second step involves nucleophilic attack by beta-alanine on the active carbonyl group of pantoyl adenylate and subsequent release of AMP and pantothenate
Mycobacterium tuberculosis ATCC 25618 / H37Rv
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