6.3.2.1: pantoate-beta-alanine ligase (AMP-forming)
This is an abbreviated version!
For detailed information about pantoate-beta-alanine ligase (AMP-forming), go to the full flat file.
Word Map on EC 6.3.2.1
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6.3.2.1
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trna
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aminoacyl-trna
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aminoacylation
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coa
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glycogen
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thromboxane
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prostaglandin
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adenylate
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carboxylase
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gsh
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neurodegeneration
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nonribosomal
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acyl-coa
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carbamyl
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anticodon
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phosphorylase
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ribonucleic
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polyketide
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polyadp-ribose
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kinase-associated
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arachidonic
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purine
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ornithine
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lipogenic
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multienzyme
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lipogenesis
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indomethacin
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adp-ribose
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palmitoyl-coa
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argininosuccinate
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lipopeptide
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tx
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transcarbamylase
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acyl-coenzyme
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ifn-alpha
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thioesterase
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3-aminobenzamide
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microcystins
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cyclooxygenase
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myositis
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dermatomyositis
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interferon-induced
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dystonia
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ifn-induced
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malonyl-coa
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amber
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ifn-beta
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polymyositis
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delta-aminolevulinic
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drug development
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6-keto-pgf1
- 6.3.2.1
- trna
- aminoacyl-trna
- aminoacylation
- coa
- glycogen
-
thromboxane
- prostaglandin
- adenylate
- carboxylase
- gsh
- neurodegeneration
-
nonribosomal
- acyl-coa
-
carbamyl
-
anticodon
- phosphorylase
-
ribonucleic
- polyketide
-
polyadp-ribose
-
kinase-associated
-
arachidonic
- purine
- ornithine
-
lipogenic
-
multienzyme
-
lipogenesis
- indomethacin
- adp-ribose
- palmitoyl-coa
- argininosuccinate
-
lipopeptide
- tx
-
transcarbamylase
-
acyl-coenzyme
- ifn-alpha
-
thioesterase
- 3-aminobenzamide
- microcystins
-
cyclooxygenase
- myositis
- dermatomyositis
-
interferon-induced
- dystonia
-
ifn-induced
- malonyl-coa
-
amber
-
ifn-beta
- polymyositis
-
delta-aminolevulinic
- drug development
-
6-keto-pgf1
Reaction
Synonyms
D-Pantoate:beta-alanine ligase (AMP-forming), MTBPS, PanC, panthotenate synthetase, Pantoate activating enzyme, pantoate-beta-alanine ligase, Pantoic-activating enzyme, pantothenate, Pantothenate synthetase, PS, PTS, Rv3602c, synthetase, Synthetase, pantothenate
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Substrates Products
Substrates Products on EC 6.3.2.1 - pantoate-beta-alanine ligase (AMP-forming)
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REACTION DIAGRAM
ATP + (R)-pantoate + beta-alanine
?
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formation of pantothenic acid, an important member of the B vitamins
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-
?
CTP + (R)-pantoate + beta-alanine
CMP + diphosphate + (R)-pantothenate
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14% of the activity relative to ATP
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-
?
GTP + (R)-pantoate + beta-alanine
GMP + diphosphate + (R)-pantothenate
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12% of the activity relative to ATP
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-
?
ITP + (R)-pantoate + beta-alanine
IMP + diphosphate + (R)-pantothenate
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14% of the activity relative to ATP
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-
?
UTP + (R)-pantoate + beta-alanine
UMP + diphosphate + (R)-pantothenate
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16% of the activity relative to ATP
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-
?
AMP + diphosphate + (R)-pantothenate
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-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
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-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
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the enzyme is involved in biosynthesis of the phosphopantetheine moiety
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-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
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synthesis of pantothenate, the essential precursor to coenzyme A
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-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
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the two-step reaction mechanism, large allosteric effects
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-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
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-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
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-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
synthesis of pantothenate, the essential precursor to coenzyme A
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
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Bi Uni Uni Bi kinetic mechanism. Enzyme displays non-allosteric behavior
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-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
Escherichia coli B / ATCC 11303
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-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
last step in pantothenate biosynthesis pathway
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
the phosphate group of AMP serves as an anchor for the binding of beta-alanine
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-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
Mycobacterium tuberculosis ATCC 25618 / H37Rv
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-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv
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-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
the phosphate group of AMP serves as an anchor for the binding of beta-alanine
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
-
-
-
?
?
-
pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis thaliana, pantothenate, i.e. vitamin B5, is the universal precursor for coenzyme A, overview
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-
?
additional information
?
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-
pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis thaliana, pantothenate, i.e. vitamin B5, is the universal precursor for coenzyme A, overview
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-
?