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6.3.2.1: pantoate-beta-alanine ligase (AMP-forming)

This is an abbreviated version!
For detailed information about pantoate-beta-alanine ligase (AMP-forming), go to the full flat file.

Word Map on EC 6.3.2.1

Reaction

ATP
+
(R)-pantoate
+
beta-Alanine
=
AMP
+
diphosphate
+
(R)-pantothenate

Synonyms

D-Pantoate:beta-alanine ligase (AMP-forming), MTBPS, PanC, panthotenate synthetase, Pantoate activating enzyme, pantoate-beta-alanine ligase, Pantoic-activating enzyme, pantothenate, Pantothenate synthetase, PS, PTS, Rv3602c, synthetase, Synthetase, pantothenate

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.1 pantoate-beta-alanine ligase (AMP-forming)

Substrates Products

Substrates Products on EC 6.3.2.1 - pantoate-beta-alanine ligase (AMP-forming)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + (R)-pantoate + beta-alanine
?
show the reaction diagram
-
formation of pantothenic acid, an important member of the B vitamins
-
-
?
ATP + (R)-pantoate + beta-alanine
AMP + diphosphate + (R)-pantothenate
show the reaction diagram
CTP + (R)-pantoate + beta-alanine
CMP + diphosphate + (R)-pantothenate
show the reaction diagram
-
14% of the activity relative to ATP
-
-
?
GTP + (R)-pantoate + beta-alanine
GMP + diphosphate + (R)-pantothenate
show the reaction diagram
-
12% of the activity relative to ATP
-
-
?
ITP + (R)-pantoate + beta-alanine
IMP + diphosphate + (R)-pantothenate
show the reaction diagram
-
14% of the activity relative to ATP
-
-
?
UTP + (R)-pantoate + beta-alanine
UMP + diphosphate + (R)-pantothenate
show the reaction diagram
-
16% of the activity relative to ATP
-
-
?
additional information
?
-