6.2.1.5: succinate-CoA ligase (ADP-forming)
This is an abbreviated version!
For detailed information about succinate-CoA ligase (ADP-forming), go to the full flat file.
Word Map on EC 6.2.1.5
-
6.2.1.5
-
mtdna
-
suclg1
-
methylmalonic
-
aciduria
-
dguok
-
encephalomyopathic
-
c10orf2
-
mimigardefordensis
-
twinkle
-
c4-dicarboxylic
-
thiokinase
-
faroe
-
gtp-forming
-
hepatocerebral
-
3,3'-dithiodipropionic
-
molecular biology
- 6.2.1.5
- mtdna
- suclg1
-
methylmalonic
-
aciduria
- dguok
-
encephalomyopathic
- c10orf2
- mimigardefordensis
- twinkle
-
c4-dicarboxylic
- thiokinase
-
faroe
-
gtp-forming
-
hepatocerebral
-
3,3'-dithiodipropionic
- molecular biology
Reaction
Synonyms
A-SCS, A-STK, A-SUCL, AarC, ADP-forming succinyl-CoA synthase, ADP-forming succinyl-CoA synthetase, ADP-forming SUCL, ATP-dependent succinate:CoA ligase, ATP-forming SUCL, ATP-SCS, ATP-specific succinate:CoA ligase, ATP-specific SUCL, ATP-succinyl-CoA synthetase, CG11963, More, SCACT, SCS, SCS A-beta, SCS ADP-forming beta subunit, SCS-alpha, SCS-beta, SCS-betaA, ScsB, STK, SucCD, SucCDAm, succinate coenzyme A ligase, Succinate thiokinase, succinate-CoA ligase, Succinic thiokinase, Succinyl coenzyme A synthetase, Succinyl coenzyme A synthetase (adenosine diphosphate-forming), succinyl-CoA ligase (ATP-forming), succinyl-CoA synthase, succinyl-CoA synthase ADP-forming beta subunit, Succinyl-CoA synthetase, Succinyl-CoA synthetase (ADP-forming), succinyl-CoA synthetase subunit alpha, succinyl-CoA-synthetase (ATP), succinyl-CoA:acetate CoA-transferase, succinyl-coenzyme A:acetate CoA-transferase, SUCL, SUCLA2, Synthetase, succinyl coenzyme A (adenosine diphosphate-forming), Tneu_1463, Tneu_1464, VEG239, VEG63, Vegetative protein 239, Vegetative protein 63
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Reference on EC 6.2.1.5 - succinate-CoA ligase (ADP-forming)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Weitzman, P.D.J.; Jaskowska-Hodges, H.
Pattern of nucleotide utilization in bacterial succinate thiokinases
FEBS Lett.
143
237-240
1982
Alcaligenes faecalis, Brevibacterium linens, Cereibacter sphaeroides, Escherichia coli, Geobacillus stearothermophilus, Klebsiella aerogenes, Kurthia zopfii, More, Paracoccus denitrificans, Pimelobacter simplex, Priestia megaterium, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas stutzeri, Salmonella enterica subsp. arizonae, Serratia marcescens, Thermus aquaticus
Buck, D.; Spencer, M.E.; Guest, J.R.
Cloning and expression of the succinyl-CoA synthetase genes of Escherichia coli K12
J. Gen. Microbiol.
132
1753-1762
1986
Escherichia coli
Allen, D.A.; Ottaway, J.H.
Succinate thiokinase in pigeon breast muscle mitochondria
FEBS Lett.
194
171-175
1986
Pigeon
Buck, D.; Spencer, M.E.; Guest, J.R.
Primary structure of the succinyl-CoA synthetase of Escherichi coli
Biochemistry
24
6245-6252
1985
Escherichia coli
Danson, M.J.; Black, S.C.; Woodland, D.L.; Wood, P.A.
Citric acid cycle enzymes of the archaebacteria: citrate synthase and succinate thiokinase
FEBS Lett.
179
120-124
1985
Escherichia coli, Haloarcula vallismortis, Halobacterium salinarum, Haloferax volcanii, Natronobacterium gregoryi, Natronococcus occultus, Natronomonas pharaonis, Priestia megaterium, Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM 639, Sus scrofa, Thermoplasma acidophilum
-
Wolodko, W.T.; James, M.N.G.; Bridger, W.A.
Crystallization of succinyl-CoA synthetase from Escherichia coli
J. Biol. Chem.
259
5316-5320
1984
Escherichia coli
Weitzman, P.D.J.; Kinghorn, H.A.
Succinate thiokinase from Thermus aquaticus and Halobacterium salinarium
FEBS Lett.
154
369-372
1983
Escherichia coli, Halobacterium salinarum, Thermus aquaticus
-
Birney, M.; Um, H.D.; Klein, C.
Novel mechanism of Escherichia coli succinyl-coenzyme A synthetase regulation
J. Bacteriol.
178
2883-2889
1996
Escherichia coli
Hamilton, M.L.; Ottaway, J.H.
An ATP-dependent succinic thiokinase in birds and its relation to ketone-body utilization
FEBS Lett.
123
252-254
1981
Gallus gallus, Pigeon
Pearson, P.H.; Bridger, W.A.
Isolation of the alpha and beta subunits of Escherichia coli succinyl coenzyme A synthetase and their recombination into active enzyme
J. Biol. Chem.
250
4451-4455
1975
Escherichia coli
Wider, E.A.; Tigier, H.A.
Porphyrin biosynthesis in soybean callus tissue system. VIII. Isolation, purification and general properties of succinyl CoA synthetase
Enzymologia
41
217-231
1971
Glycine max
Thomas, E.L.
Studies on the metabolism of ATP by isolated bacterial membranes: role of succinyl CoA synthetase in diglyceride kinase activity
Arch. Biochem. Biophys.
163
530-536
1974
Escherichia coli
Krebs, A.; Bridger, W.A.
Some physical parameters of succinyl-coenzyme A synthetase of Eschericha coli
Can. J. Biochem.
52
594-598
1974
Escherichia coli
Hansford, R.G.
An adenine nucleotide-linked succinic thiokinase of animal origin
FEBS Lett.
31
317-320
1973
Calliphoridae
Moffet, F.J.; Wang, T.T.; Bridger, W.A
Succinyl coenzyme A synthetase of Escherichia coli. Effects of phosphoenzyme formation and substrate binding on the reactivity and stability of the enzyme
J. Biol. Chem.
247
8139-8144
1972
Escherichia coli
Murakami, K.; Mitchell, T.; Nishimura, J.S.
Nucleotide specificity of Escherichia coli succinic thiokinase
J. Biol. Chem.
247
6247-6252
1972
Escherichia coli
Hager, L.P.
Succinyl CoA synthetase
The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. )
6
387-399
1962
Escherichia coli, Spinacia oleracea, Sus scrofa
-
Mann, C.J.; Hardies, S.C.; Nishimura, J.S.
Site-directed mutagenesis of Escherichia coli succinyl-CoA synthetase. beta-Cys325 is a nonessential active site residue
J. Biol. Chem.
264
1457-1460
1989
Escherichia coli
Khan, I.A.; Nishimura, J.S.
Native-like intermediate on the folding pathway of Escherichia coli succinyl-CoA synthetase
J. Biol. Chem.
263
2152-2158
1988
Escherichia coli
Wider de Xifra, E.A.; Del C.Batlle, A.M.
Porphyrin biosynthesis: immobilized enzymes and ligands. VI. Studies on succinyl CoA synthetase from cultured soya bean cells
Biochim. Biophys. Acta
523
245-249
1978
Glycine max
Nishimura, J.S.; Mitchell, T.; Matula, J.M.
Inactivation of Escherichia coli succinic thiokinase by selective oxidation of thiol groups by permanganate
Biochem. Biophys. Res. Commun.
69
1057-1064
1976
Escherichia coli
Kondo, H.; Ohmori, T.; Shibata, H.; Sase, K.; Takahashi, R.; Tokuyama, T.
Thermostable succinyl-coenzyme A synthetase from Nitrosomonas europaea ATCC 25978: purification and properties
J. Ferment. Bioeng.
79
499-502
1995
Nitrosomonas europaea
-
Kavanaugh-Black, A.; Connolly, D.M.; Chugani, S.A.; Chakrabarty, A.M.
Characterization of nucleoside-diphosphate kinase from Pseudomonas aeruginosa: Complex formation with succinyl-CoA synthetase
Proc. Natl. Acad. Sci. USA
91
5883-5887
1994
Pseudomonas aeruginosa
Krivanek, J.; Novakova, L.
A novel effect of vanadium ions: inhibition of succinyl-CoA synthetase
Gen. Physiol. Biophys.
10
71-82
1991
Rattus norvegicus
Krivanek, J.; Novakova, L.
Differential sensitivity of the brain ATP-dependent and GTP-dependent succinyl-CoA synthetase to vanadium ions. Developmental aspects
Physiol. Res.
41
345-350
1992
Rattus norvegicus
Fong, G.; Bridger, W.A.
Folding and assembly of the Escherichia coli succinyl-CoA synthetase heterotetramer without participation of molecular chaperones
Biochemistry
31
5661-5664
1992
Escherichia coli
Majumdar, R.; Guest, J.R.; Bridger, W.A.
Functional consequences of substitution of the active site (phospho)histidine residue of Escherichia coli succinyl-CoA synthetase
Biochim. Biophys. Acta
1076
86-90
1991
Escherichia coli
Lahti, C.J.; Bradley, P.J.; Johnson, P.J.
Molecular characterization of the alpha-subunit of Trichomonas vaginalis hydrogenosomal succinyl CoA synthetase
Mol. Biochem. Parasitol.
66
309-318
1994
Trichomonas vaginalis
Luo, G.X.; Nishimura, J.S.
Adenosine 5¦-tetraphosphate is synthesized by the histidine alpha142-->asparagine mutant of Escherichia coli succinyl-CoA synthetase
J. Biol. Chem.
267
9516-9520
1992
Escherichia coli
Nishimura, J.S.; Ybarra, J.; Mann, C.J.; Mitchell, T.
Sensitivity of Escherichia coli succinyl-CoA mutants at Trp beta 76 to clostripain and to trypsin. ADP and ATP protect against cleavage by clostripain at Arg beta 80
J. Biol. Chem.
268
13717-13722
1993
Escherichia coli
Brondijk, T.H.C.; Durand, R.; van der Giezen, M.; Gottschal, J.C.; Prins, R.A.; Fevre, M.
scsB, a cDNA encoding the hydrogenosomal beta subunit of succinyl-CoA synthetase from the anaerobic fungus Neocallimastix frontalis
Mol. Gen. Genet.
253
315-323
1996
Neocallimastix frontalis
Nishiyama, M.; Horinouchi, S.; Beppu, T.
Characterization of an operon encoding succinyl-CoA synthetase and malate dehydrogenase from Thermus flavus AT-62 and its expression in Escherichia coli
Mol. Gen. Genet.
226
1-9
1991
Thermus thermophilus, Thermus thermophilus AT-62
Joyce, M.A.; Fraser, M.E.; James, M.N.; Bridger, W.A.; Wolodko, W.T.
ADP-binding site of Escherichia coli succinyl-CoA synthetase revealed by X-ray crystallography
Biochemistry
39
17-25
2000
Escherichia coli
Fraser, M.E.; Joyce, M.A.; Ryan, D.G.; Wolodko, W.T.
Two glutamate residues,Glu 208alpha and Glu 197beta, are crucial for phosphorylation and dephosphorylation of the active-site histidine residue in succinyl-CoA synthetase
Biochemistry
41
537-546
2002
Escherichia coli
Kowluru, A.
Adenine and guanine nucleotide-specific succinyl-CoA synthetases in the clonal beta-cell mitochondria: implications in the beta-cell high-energy phosphate metabolism in relation to physiological insulin secretion
Diabetologia
44
89-94
2001
Rattus norvegicus
Johnson, J.D.; Muhonen, W.W.; Lambeth, D.O.
Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit
J. Biol. Chem.
273
27573-27579
1998
Columba livia
Fraser, M.E.; James, M.N.G.; Bridger, W.A.; Wolodko, W.T.
A detailed structural description of Escherichia coli succinyl-CoA synthetase
J. Mol. Biol.
285
1633-1653
1999
Escherichia coli
Bailey, D.L.; Fraser, M.E.; Bridger, W.A.; James, M.N.; Wolodko, W.T.
A dimeric form of Escherichia coli succinyl-CoA synthetase produced by site-directed mutagenesis
J. Mol. Biol.
285
1655-1666
1999
Escherichia coli
Elpeleg, O.; Miller, C.; Hershkovitz, E.; Bitner-Glindzicz, M.; Bondi-Rubinstein, G.; Rahman, S.; Pagnamenta, A.; Eshhar, S.; Saada, A.
Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion
Am. J. Hum. Genet.
76
1081-1086
2005
Homo sapiens
Hidber, E.; Brownie, E.R.; Hayakawa, K.; Fraser, M.E.
Participation of Cys123alpha of Escherichia coli succinyl-CoA synthetase in catalysis
Acta Crystallogr. Sect. D
D63
876-884
2007
Escherichia coli
Joyce, M.A.; Brownie, E.R.; Hayakawa, K.; Fraser, M.E.
Cloning, expression, purification, crystallization and preliminary X-ray analysis of Thermus aquaticus succinyl-CoA synthetase
Acta Crystallogr. Sect. F
63
399-402
2007
Thermus aquaticus
Dacks, J.B.; Dyal, P.L.; Embley, T.M.; van der Giezen, M.
Hydrogenosomal succinyl-CoA synthetase from the rumen-dwelling fungus Neocallimastix patriciarum; an energy-producing enzyme of mitochondrial origin
Gene
373
75-82
2006
Neocallimastix patriciarum (Q7Z940), Neocallimastix patriciarum (Q7Z941)
Shikata, K.; Fukui, T.; Atomi, H.; Imanaka, T.
A novel ADP-forming succinyl-CoA synthetase in Thermococcus kodakaraensis structurally related to the archaeal nucleoside diphosphate-forming acetyl-CoA synthetases
J. Biol. Chem.
282
26963-26970
2007
Thermococcus kodakarensis
Solow, B.; Bischoff, K.M.; Zylka, M.J.; Kennelly, P.J.
Archael phosphoproteins. Identification of a hexosephosphate mutase and the alpha-subunit of succinyl-CoA synthetase in the extreme acidothermophile Sulfolobus solfataricus
Protein Sci.
7
105-111
1998
Saccharolobus solfataricus
Fleige, T.; Pfaff, N.; Gross, U.; Bohne, W.
Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii
Int. J. Parasitol.
38
1121-1132
2008
Toxoplasma gondii (Q1KSE5)
Mullins, E.A.; Francois, J.A.; Kappock, T.J.
A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti
J. Bacteriol.
190
4933-4940
2008
Acetobacter aceti (B3EY95)
Ostergaard, E.
Disorders caused by deficiency of succinate-CoA ligase
J. Inherit. Metab. Dis.
31
226-229
2008
Homo sapiens, Homo sapiens (P53597), Homo sapiens (Q9P2R7)
Gao, L.; Fei, H.; Connors, N.C.; Zhang, J.; Levitan, I.B.
Drosophila ortholog of succinyl-CoA synthetase {beta} subunit: a novel modulator of Drosophila KCNQ channels
J. Neurophysiol.
99
2736-2740
2008
Drosophila melanogaster
Hamblin, K.; Standley, D.M.; Rogers, M.B.; Stechmann, A.; Roger, A.J.; Maytum, R.; van der Giezen, M.
Localization and nucleotide specificity of Blastocystis succinyl-CoA synthetase
Mol. Microbiol.
68
1395-1405
2008
Blastocystis sp.
Phillips, D.; Aponte, A.M.; French, S.A.; Chess, D.J.; Balaban, R.S.
Succinyl-CoA synthetase is a phosphate target for the activation of mitochondrial metabolism
Biochemistry
48
7140-7149
2009
Sus scrofa
Miller, C.; Wang, L.; Ostergaard, E.; Dan, P.; Saada, A.
The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion
Biochim. Biophys. Acta
1812
625-629
2011
Homo sapiens
Schuermann, M.; Wuebbeler, J.H.; Grote, J.; Steinbuechel, A.
Novel reaction of succinyl coenzyme A (succinyl-CoA) synthetase: activation of 3-sulfinopropionate to 3-Sulfinopropionyl-CoA in Advenella mimigardefordensis strain DPN7T during degradation of 3,3-dithiodipropionic acid
J. Bacteriol.
193
3078-3089
2011
Advenella mimigardefordensis (B3TZD8), Advenella mimigardefordensis (B3TZD9), Advenella mimigardefordensis, Advenella mimigardefordensis DPN7T (B3TZD8), Advenella mimigardefordensis DPN7T (B3TZD9)
Nolte, J.C.; Schuermann, M.; Schepers, C.L.; Vogel, E.; Wuebbeler, J.H.; Steinbuechel, A.
Novel characteristics of succinate coenzyme A (succinate-CoA) ligases: conversion of malate to malyl-CoA and CoA-thioester formation of succinate analogues in vitro
Appl. Environ. Microbiol.
80
166-176
2014
Escherichia coli K-12 (P0A836), Escherichia coli K-12 (P0AGE9), Alcanivorax borkumensis (Q0VPF7), Alcanivorax borkumensis (Q0VPF8), Alcanivorax borkumensis, Advenella mimigardefordensis (W0PAN5), Advenella mimigardefordensis (W0PFR9), Advenella mimigardefordensis, Alcanivorax borkumensis SK2 (Q0VPF7), Alcanivorax borkumensis SK2 (Q0VPF8), Alcanivorax borkumensis SK2, Advenella mimigardefordensis DPN7 (W0PAN5), Advenella mimigardefordensis DPN7 (W0PFR9), Escherichia coli K-12 BL21 (P0A836), Escherichia coli K-12 BL21 (P0AGE9)
Ramos-Vera, W.H.; Labonte, V.; Weiss, M.; Pauly, J.; Fuchs, G.
Regulation of autotrophic CO2 fixation in the archaeon Thermoproteus neutrophilus
J. Bacteriol.
192
5329-5340
2010
Pyrobaculum neutrophilum (B1Y9F9 and B1Y9G0), Pyrobaculum neutrophilum DSM 2338 (B1Y9F9 and B1Y9G0)
Bishop, D.F.; Tchaikovskii, V.; Hoffbrand, A.V.; Fraser, M.E.; Margolis, S.
X-linked sideroblastic anemia due to carboxyl-terminal ALAS2 mutations that cause loss of binding to the beta-subunit of succinyl-CoA synthetase (SUCLA2)
J. Biol. Chem.
287
28943-28955
2012
Homo sapiens (Q9P2R7)
Luis, P.B.; Ruiter, J.; Ijlst, L.; de Almeida, I.T.; Duran, M.; Wanders, R.J.; Silva, M.F.
Valproyl-CoA inhibits the activity of ATP- and GTP-dependent succinate:CoA ligases
J. Inherit. Metab. Dis.
37
353-357
2013
Homo sapiens
Kacso, G.; Ravasz, D.; Doczi, J.; Nemeth, B.; Madgar, O.; Saada, A.; Ilin, P.; Miller, C.; Ostergaard, E.; Iordanov, I.; Adams, D.; Vargedo, Z.; Araki, M.; Araki, K.; Nakahara, M.; Ito, H.; Gal, A.; Molnar, M.J.; Nagy, Z.; Patocs, A.; Adam-Vizi, V.; Chinopoulos, C.
Two transgenic mouse models for beta-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations
Biochem. J.
473
3463-3485
2016
Mus musculus
Luis, P.; Ruiter, J.; IJlst, L.; De Almeida, I.; Duran, M.; Wanders, R.; Silva, M.
Valproyl-CoA inhibits the activity of ATP- and GTP-dependent succinate CoA ligases
J. Inherit. Metab. Dis.
37
353-357
2014
Homo sapiens
Carrozzo, R.; Verrigni, D.; Rasmussen, M.; de Coo, R.; Amartino, H.; Bianchi, M.; Buhas, D.; Mesli, S.; Naess, K.; Born, A.P.; Woldseth, B.; Prontera, P.; Batbayli, M.; Ravn, K.; Joensen, F.; Cordelli, D.M.; Santorelli, F.M.; Tulinius, M.; Darin, N.; Duno, M.; Jouvencel, P.; Burlina, A.; Stangoni, G.; , B.
Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1 phenotype and genotype correlations in 71 patients
J. Inherit. Metab. Dis.
39
243-252
2016
Homo sapiens (Q9P2R7), Homo sapiens
Huang, X.; Bedoyan, J.K.; Demirbas, D.; Harris, D.J.; Miron, A.; Edelheit, S.; Grahame, G.; DeBrosse, S.D.; Wong, L.J.; Hoppel, C.L.; Kerr, D.S.; Anselm, I.; Berry, G.T.
Succinyl-CoA synthetase (SUCLA2) deficiency in two siblings with impaired activity of other mitochondrial oxidative enzymes in skeletal muscle without mitochondrial DNA depletion
Mol. Genet. Metab.
120
213-222
2017
Homo sapiens (Q9P2R7)
Gomes, C.; Palma, N.; Pons, M.J.; Magallon-Tejada, A.; Sandoval, I.; Tinco-Valdez, C.; Gutarra, C.; Del Valle-Mendoza, J.; Ruiz, J.; Matsuoka, M.
Succinyl-CoA synthetase New antigen candidate of Bartonella bacilliformis
PLoS Negl. Trop. Dis.
10
e0004989
2016
Bartonella bacilliformis
Zhao, Y.; Tian, J.; Sui, S.; Yuan, X.; Chen, H.; Qu, C.; Du, Y.; Guo, L.; Du, H.
Loss of succinyl-CoA synthase ADP-forming ? subunit disrupts mtDNA stability and mitochondrial dynamics in neurons
Sci. Rep.
7
7169
2017
Mus musculus (Q9Z2I9)
Zhong, Z.; Li, L.; Chang, P.; Xie, H.; Zhang, H.; Igarashi, Y.; Li, N.; Luo, F.
Differential gene expression profiling analysis in Pleurotus ostreatus during interspecific antagonistic interactions with Dichomitus squalens and Trametes versicolor
Fungal Biol.
121
1025-1036
2017
Pleurotus ostreatus
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