6.2.1.5: succinate-CoA ligase (ADP-forming)
This is an abbreviated version!
For detailed information about succinate-CoA ligase (ADP-forming), go to the full flat file.
Word Map on EC 6.2.1.5
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6.2.1.5
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mtdna
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suclg1
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methylmalonic
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aciduria
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dguok
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encephalomyopathic
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c10orf2
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mimigardefordensis
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twinkle
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c4-dicarboxylic
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thiokinase
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faroe
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gtp-forming
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hepatocerebral
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3,3'-dithiodipropionic
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molecular biology
- 6.2.1.5
- mtdna
- suclg1
-
methylmalonic
-
aciduria
- dguok
-
encephalomyopathic
- c10orf2
- mimigardefordensis
- twinkle
-
c4-dicarboxylic
- thiokinase
-
faroe
-
gtp-forming
-
hepatocerebral
-
3,3'-dithiodipropionic
- molecular biology
Reaction
Synonyms
A-SCS, A-STK, A-SUCL, AarC, ADP-forming succinyl-CoA synthase, ADP-forming succinyl-CoA synthetase, ADP-forming SUCL, ATP-dependent succinate:CoA ligase, ATP-forming SUCL, ATP-SCS, ATP-specific succinate:CoA ligase, ATP-specific SUCL, ATP-succinyl-CoA synthetase, CG11963, More, SCACT, SCS, SCS A-beta, SCS ADP-forming beta subunit, SCS-alpha, SCS-beta, SCS-betaA, ScsB, STK, SucCD, SucCDAm, succinate coenzyme A ligase, Succinate thiokinase, succinate-CoA ligase, Succinic thiokinase, Succinyl coenzyme A synthetase, Succinyl coenzyme A synthetase (adenosine diphosphate-forming), succinyl-CoA ligase (ATP-forming), succinyl-CoA synthase, succinyl-CoA synthase ADP-forming beta subunit, Succinyl-CoA synthetase, Succinyl-CoA synthetase (ADP-forming), succinyl-CoA synthetase subunit alpha, succinyl-CoA-synthetase (ATP), succinyl-CoA:acetate CoA-transferase, succinyl-coenzyme A:acetate CoA-transferase, SUCL, SUCLA2, Synthetase, succinyl coenzyme A (adenosine diphosphate-forming), Tneu_1463, Tneu_1464, VEG239, VEG63, Vegetative protein 239, Vegetative protein 63
ECTree
6.2.1.5 succinate-CoA ligase (ADP-forming)Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 6.2.1.5 - succinate-CoA ligase (ADP-forming)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + succinate + CoA
?
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generation of succinyl-CoA from succinate for anabolic purposes when the route from 2-oxoglutarate is repressed, e.g. under anaerobic conditions
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?
ADP + phosphate + succinyl-CoA
?
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the enzyme plays an essential role in the citric acid cycle, where the conversion of succinyl-CoA into succinate represents an important site of substrate level phosphorylation
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?
ADP + phosphate + succinyl-CoA
?
-
catalyzes the formation of ATP via substrate-level phosphorylation
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-
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
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the enzyme carries out the substrate-level phosphorylation in the citric acid cycle
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?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
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the enzyme carries out the substrate-level phosphorylation in the citric acid cycle
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?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
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generation of ATP is critical for the beta-cell mitochondrial metabolism
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?
ATP + acetate + CoA
ADP + phosphate + acetyl-CoA
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Blastocystis succinyl-CoA synthetase is a tricarboxylic acid cycle enzyme that conserves energy by substrate-level phosphorylation. In the absence of a classic mitochondrial electron transport chain, it is likely to be one of the main ATP producing enzymes in this parasite
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r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
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-
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r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
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-
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r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
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-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
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-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
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-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
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-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
AarC is succinyl-CoA:acetate CoA-transferase, which replaces succinyl-CoA synthetase in a variant CAC, this new bypass appears to reduce metabolic demand for free CoA, reliance upon nucleotide pools, and the likely effect of variable cytoplasmic pH upon CAC flux, the enzyme is required for the citric acid cycle, overview
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-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
SucCDAm is unspecific regarding ATP or GTP
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-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
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-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
SucCDAm is unspecific regarding ATP or GTP
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-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
ATP is the preferred cosubstrate
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-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
ATP is the preferred cosubstrate
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-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
the enzyme is part of the Krebs cycle
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-
?
additional information
?
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a Drosophila orthologue of succinyl-CoA synthetase beta-subunit is a modulator of Drosophila KCNQ channels responsible for slowly activating potassium currents in heart, brain, and other tissues, direct interaction with the intracellular C-terminal tail KCNQ channel, overview
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?
additional information
?
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diglyceride kinase can use either ATP or the phosphorylated form of succinyl CoA synthetase as phosphate donor for the phosphorylation of diglyceride
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?
additional information
?
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enzyme is involved in the initial step of porphyrin biosynthesis
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?
additional information
?
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deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion
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?
additional information
?
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succinate-CoA ligase catalyses the reversible conversion of succinyl-CoA and ADP or GDP to succinate and ATP or GTP, cf. GTP-specific succinate:CoA ligase, EC 6.2.1.4
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-
?
additional information
?
-
succinate-CoA ligase catalyses the reversible conversion of succinyl-CoA and ADP or GDP to succinate and ATP or GTP, cf. GTP-specific succinate:CoA ligase, EC 6.2.1.4
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-
?
additional information
?
-
succinate-CoA ligase catalyses the reversible conversion of succinyl-CoA and ADP or GDP to succinate and ATP or GTP, cf. GTP-specific succinate:CoA ligase, EC 6.2.1.4
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-
?
additional information
?
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the enzyme beta-subunit binds strongly to wild-type erythroid-specific aminolevulinic acid synthase, but not to the mutants M567V and S568G, aminolevulinic acid synthase mutant R452C shows binding to the succinyl-CoA synthetase, but with reduced affinity and positive cooperativity for succinyl-CoA
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?
