6.2.1.5: succinate-CoA ligase (ADP-forming)

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For detailed information about succinate-CoA ligase (ADP-forming), go to the full flat file.

Reaction

Synonyms

A-SCS, A-STK, A-SUCL, AarC, ADP-forming succinyl-CoA synthase, ADP-forming succinyl-CoA synthetase, ADP-forming SUCL, ATP-dependent succinate:CoA ligase, ATP-forming SUCL, ATP-SCS, ATP-specific succinate:CoA ligase, ATP-specific SUCL, ATP-succinyl-CoA synthetase, CG11963, More, SCACT, SCS, SCS A-beta, SCS ADP-forming beta subunit, SCS-alpha, SCS-beta, SCS-betaA, ScsB, STK, SucCD, SucCDAm, succinate coenzyme A ligase, Succinate thiokinase, succinate-CoA ligase, Succinic thiokinase, Succinyl coenzyme A synthetase, Succinyl coenzyme A synthetase (adenosine diphosphate-forming), succinyl-CoA ligase (ATP-forming), succinyl-CoA synthase, succinyl-CoA synthase ADP-forming beta subunit, Succinyl-CoA synthetase, Succinyl-CoA synthetase (ADP-forming), succinyl-CoA synthetase subunit alpha, succinyl-CoA-synthetase (ATP), succinyl-CoA:acetate CoA-transferase, succinyl-coenzyme A:acetate CoA-transferase, SUCL, SUCLA2, Synthetase, succinyl coenzyme A (adenosine diphosphate-forming), Tneu_1463, Tneu_1464, VEG239, VEG63, Vegetative protein 239, Vegetative protein 63

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.5 succinate-CoA ligase (ADP-forming)

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Results	in table
4	Activating Compound
69797	AA Sequence
1	Application
1	CAS Registry Number
19	Cloned(Commentary)
24	Cofactor
4	Crystallization (Commentary)
120	Disease/ Diagnostics
3	Expression
20	General Information
4	General Stability
68	Inhibitors
20	kcat/KM [mM/s]
96	KM Value [mM]
21	Localization
18	Metals/Ions
41	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
136	Organism
27	Pathway
93	PDB ID
11	pH Optimum
3	pH Range
1	pH Stability
5	pI Value
2	Posttranslational Modification
47	Protein Variants
17	Purification (Commentary)
2	Reaction
1	Reaction Type
116	Reference
3	Renatured (Commentary)
52	Source Tissue
13	Specific Activity [micromol/min/mg]
1	Storage Stability
189	Substrates and Products (Substrate)
22	Subunits
127	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
2	Temperature Range [°C]
12	Temperature Stability [°C]
48	Turnover Number [1/s]

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RENATURED/Commentary

ORGANISM

UNIPROT

LITERATURE

50-60% of the activity can be recovered following renaturation. ATP is required for reconstitution

Escherichia coli

-

804

enzyme that is completely inactivated by 0.6 M guanidine hydrochloride, but contains 90% residual native structure, can refold back to fully active enzyme. Enzyme denatured in 1.5 M and 6.0 M guanidine hydrochloride, that is catalytically inactive and devoid of a large fraction of the native enzyme structure, can also regain the native structure upon refolding, but the refolded structures are only 86% and 71% active, respectively

Escherichia coli

-

813

purified bacterial chaperone GroEL has no effect on the folding and assembly of succinyl-CoA synthetase

Escherichia coli

-

820