6.2.1.15: arachidonate-CoA ligase
This is an abbreviated version!
For detailed information about arachidonate-CoA ligase, go to the full flat file.
Word Map on EC 6.2.1.15
Reaction
Synonyms
ACSL4, Acyl-CoA synthetase, Arachidonoyl-CoA synthetase, FACL4
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6.2.1.15 arachidonate-CoA ligaseAdvanced search results
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Natural Substrates Products on EC 6.2.1.15 - arachidonate-CoA ligase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + arachidonate + CoA
?
-
enzyme may control the level of free arachidonate in platelets, limiting prostaglandin synthesis by the unstimulated cell and capturing free arachidonate from extracellular sources
-
-
?
ATP + arachidonate + CoA
?
-
enzyme is required for arachidonate homeostasis in HSDM1C1 cells
-
-
?
ATP + arachidonate + CoA
?
-
possible role in lymphocyte activation and as a homeostatic mechanism during essential fatty acid deficiency
-
-
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
arachidonic acid is a preferred substrate for ACSL4 variant 1 in intact human smooth muscle cells
-
-
?
