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Literature summary for 6.2.1.15 extracted from

  • Maloberti, P.M.; Duarte, A.B.; Orlando, U.D.; Pasqualini, M.E.; Solano, A.R.; Lopez-Otin, C.; Podesta, E.J.
    Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells (2010), PLoS ONE, 5, e15540.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.15

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of ACSL4 in the MCF-7 Tet-off/ACSL4 cell line affects cell proliferation Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information a model of ACSL4 knock-down shows a very clear reduction in mRNA and protein levels that paralleles the reduction in cell growth Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + arachidonate + CoA Homo sapiens
-
 AMP + diphosphate + arachidonoyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell a breast cancer cell model, comprising different cell lines, expresses ACSL4 in all cell lines, high expression level Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
additional information ACSL4 is abundant in steroidogenic tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + arachidonate + CoA
-
 Homo sapiens AMP + diphosphate + arachidonoyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACSL4
-
 Homo sapiens
Acyl-CoA synthetase
-
 Homo sapiens
FACL4
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism The alternative pathway, in which the rate-limiting enzyme is ACSL4, provides arachidonoyl-CoA to a mitochondrial acyl-CoA thioesterase that releases AA in mitochondria and directs this fatty acid to the lipooxygenase for its subsequent conversion to lipooxygenase metabolites Homo sapiens
physiological function the acyl-CoA synthetase, ACSL4, belongs to a five member family of enzymes that esterify mainly arachidonic acid into acyl-CoA. Role of ACSL4 and acyl-CoA thioesterase, ACOT2, in the production of lipooxygenase metabolites in breast cancer cells, regulation, overview. ACSL4 is the rate-limiting enzyme for intramitochondrial arachidonic acid generation and export, for the conversion to lipooxygenase metabolites Homo sapiens