Cloned (Comment) | Organism |
---|---|
overexpression of ACSL4 in the MCF-7 Tet-off/ACSL4 cell line affects cell proliferation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a model of ACSL4 knock-down shows a very clear reduction in mRNA and protein levels that paralleles the reduction in cell growth | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + arachidonate + CoA | Homo sapiens | - |
AMP + diphosphate + arachidonoyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | a breast cancer cell model, comprising different cell lines, expresses ACSL4 in all cell lines, high expression level | Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
additional information | ACSL4 is abundant in steroidogenic tissues | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + arachidonate + CoA | - |
Homo sapiens | AMP + diphosphate + arachidonoyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACSL4 | - |
Homo sapiens |
Acyl-CoA synthetase | - |
Homo sapiens |
FACL4 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | The alternative pathway, in which the rate-limiting enzyme is ACSL4, provides arachidonoyl-CoA to a mitochondrial acyl-CoA thioesterase that releases AA in mitochondria and directs this fatty acid to the lipooxygenase for its subsequent conversion to lipooxygenase metabolites | Homo sapiens |
physiological function | the acyl-CoA synthetase, ACSL4, belongs to a five member family of enzymes that esterify mainly arachidonic acid into acyl-CoA. Role of ACSL4 and acyl-CoA thioesterase, ACOT2, in the production of lipooxygenase metabolites in breast cancer cells, regulation, overview. ACSL4 is the rate-limiting enzyme for intramitochondrial arachidonic acid generation and export, for the conversion to lipooxygenase metabolites | Homo sapiens |