Literature summary for 6.2.1.15 extracted from

Golej, D.L.; Askari, B.; Kramer, F.; Barnhart, S.; Vivekanandan-Giri, A.; Pennathur, S.; Bornfeldt, K.E.
Long-chain acyl-CoA synthetase 4 modulates prostaglandin E2 release from human arterial smooth muscle cells (2011), J. Lipid Res., 52, 782-793.

Search for more literature for 6.2.1.15

Cloned(Commentary)

Cloned (Comment)	Organism
functional overexpression of ACSL4 variant 1 in smooth muscle cells using a retroviral vector, semiquantitative and quantitative real-time PCR expression analysis	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	downregulation of ACSL4 by stable expression of ACSL4 siRNAs in immortalized human primary aortic smooth muscle cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + arachidonate + CoA	Homo sapiens	arachidonic acid is a preferred substrate for ACSL4 variant 1 in intact human smooth muscle cells	AMP + diphosphate + arachidonoyl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60488	ACSL4 variant 1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
smooth muscle cell	aortic	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + arachidonate + CoA	preferred substrate	Homo sapiens	AMP + diphosphate + arachidonoyl-CoA	-	?
ATP + arachidonate + CoA	arachidonic acid is a preferred substrate for ACSL4 variant 1 in intact human smooth muscle cells	Homo sapiens	AMP + diphosphate + arachidonoyl-CoA	-	?

Synonyms

Synonyms	Comment	Organism
ACSL4	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)