6.2.1.15: arachidonate-CoA ligase
This is an abbreviated version!
For detailed information about arachidonate-CoA ligase, go to the full flat file.
Reaction
Synonyms
ACSL4, Acyl-CoA synthetase, Arachidonoyl-CoA synthetase, FACL4
ECTree
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General Information
General Information on EC 6.2.1.15 - arachidonate-CoA ligase
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metabolism
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The alternative pathway, in which the rate-limiting enzyme is ACSL4, provides arachidonoyl-CoA to a mitochondrial acyl-CoA thioesterase that releases AA in mitochondria and directs this fatty acid to the lipooxygenase for its subsequent conversion to lipooxygenase metabolites
physiological function
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the acyl-CoA synthetase, ACSL4, belongs to a five member family of enzymes that esterify mainly arachidonic acid into acyl-CoA. Role of ACSL4 and acyl-CoA thioesterase, ACOT2, in the production of lipooxygenase metabolites in breast cancer cells, regulation, overview. ACSL4 is the rate-limiting enzyme for intramitochondrial arachidonic acid generation and export, for the conversion to lipooxygenase metabolites