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6.2.1.15: arachidonate-CoA ligase

This is an abbreviated version!
For detailed information about arachidonate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.15

Reaction

ATP
+
arachidonate
+
CoA
=
AMP
+
diphosphate
+
Arachidonoyl-CoA

Synonyms

ACSL4, Acyl-CoA synthetase, Arachidonoyl-CoA synthetase, FACL4

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.15 arachidonate-CoA ligase

General Information

General Information on EC 6.2.1.15 - arachidonate-CoA ligase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
-
The alternative pathway, in which the rate-limiting enzyme is ACSL4, provides arachidonoyl-CoA to a mitochondrial acyl-CoA thioesterase that releases AA in mitochondria and directs this fatty acid to the lipooxygenase for its subsequent conversion to lipooxygenase metabolites
physiological function
-
the acyl-CoA synthetase, ACSL4, belongs to a five member family of enzymes that esterify mainly arachidonic acid into acyl-CoA. Role of ACSL4 and acyl-CoA thioesterase, ACOT2, in the production of lipooxygenase metabolites in breast cancer cells, regulation, overview. ACSL4 is the rate-limiting enzyme for intramitochondrial arachidonic acid generation and export, for the conversion to lipooxygenase metabolites