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6.1.1.26: pyrrolysine-tRNAPyl ligase

This is an abbreviated version!
For detailed information about pyrrolysine-tRNAPyl ligase, go to the full flat file.

Word Map on EC 6.1.1.26

Reaction

ATP
+
L-pyrrolysine
 +
tRNAPyl
=
AMP
 +
diphosphate
 +
L-pyrrolysyl-tRNAPyl

Synonyms

class II aminoacyl-tRNA synthetase, DhaPylSc, LysZ-RS, More, PylRS, PylS, PylSc, PylSn, pyrrolysyl-tRNA synthetase

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.26 pyrrolysine-tRNAPyl ligase

KM Value

KM Value on EC 6.1.1.26 - pyrrolysine-tRNAPyl ligase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.39
2-amino-6-((R)-tetrahydrofuran-2-carboxamido)hexanoic acid
-
pH 7.2, 37°C
5.6
2-amino-6-(cyclopentanecarboxamido)hexanoic acid
-
pH 7.2, 37°C
1 - 22.8
L-phenylalanine
0.044 - 0.055
L-pyrrolysine
7.8 - 35.3
N-acetyl-L-lysine
0.67
N-epsilon-cyclopentyloxycarbonyl-L-lysine
-
pH 7.2, 37°C, recombinant enzyme
0.5
N-epsilon-D-prolyl-L-lysine
-
pH 7.2, 37°C, recombinant enzyme
0.55
Nepsilon-cyclopentyloxycarbonyl-L-lysine
-
pH 7.2, 37°C
0.053
pyrrolysine
-
pH 7.2, 37°C, recombinant enzyme
0.0029
tRNAPyl
-
pH 7.2, 37°C, wild-type tRNAPyl
0.00015 - additional information
additional information
-