6.1.1.24: glutamate-tRNAGln ligase
This is an abbreviated version!
For detailed information about glutamate-tRNAGln ligase, go to the full flat file.
Word Map on EC 6.1.1.24
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6.1.1.24
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glutaminyl-trna
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aminoacylation
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gln-trnagln
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trnaglu
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aminoacyl-trnas
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synthetases
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amidotransferase
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glutamylates
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archaea
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transamidation
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gatcab
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anticodons
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thermautotrophicus
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glutaminylated
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methanothermobacter
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mischarged
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apicoplast
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isoacceptors
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glurss
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eukarya
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anticodon-binding
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berghei
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heterotrimeric
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arc1p
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lupinus
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luteus
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misaminoacylated
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noncognate
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drug development
- 6.1.1.24
- glutaminyl-trna
- aminoacylation
- gln-trnagln
- trnaglu
- aminoacyl-trnas
- synthetases
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amidotransferase
-
glutamylates
- archaea
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transamidation
- gatcab
-
anticodons
- thermautotrophicus
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glutaminylated
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methanothermobacter
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mischarged
- apicoplast
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isoacceptors
- glurss
- eukarya
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anticodon-binding
- berghei
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heterotrimeric
- arc1p
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lupinus
- luteus
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misaminoacylated
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noncognate
- drug development
Reaction
Synonyms
Glu-Q-RS, GluRS, GluRS1, GluRS2, GluRSND, glutamyl-queuosine tRNAAsp synthetase, Glutamyl-tRNA synthetase, GlxRS, ND-GluRS, non-discriminating GluRS, non-discriminating glutamyl-tRNA synthetase, nondiscriminating GluRS, nondiscriminating glutamyl-tRNA synthetase, Pf3D7_1357200, TM1875
ECTree
6.1.1.24 glutamate-tRNAGln ligaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 6.1.1.24 - glutamate-tRNAGln ligase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + L-Glu + tRNAGln
AMP + diphosphate + Glu-tRNAGln
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-
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?
ATP + L-glutamate + tRNAAsp
AMP + diphosphate + L-glutamyl-tRNAAsp
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the L-glutamyl-queuosine tRNAAsp synthetase, Glu-Q-RS from Escherichia coli is a paralogue of the catalytic core of glutamyl-tRNA synthetase, GluRS, that catalyzes glutamylation of queuosine in the wobble position of tRNAAsp
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-
?
ATP + L-glutamate + tRNAGln
AMP + diphosphate + glutamyl-tRNAGln
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-
-
-
?
ATP + L-glutamate + tRNAGlx
AMP + diphosphate + glutamyl-tRNAGlx
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-
-
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?
ATP + L-glutamate + tRNAGln
AMP + diphosphate + L-glutamyl-tRNAGln
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-
-
?
ATP + L-glutamate + tRNAGln
AMP + diphosphate + L-glutamyl-tRNAGln
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-
-
?
ATP + L-glutamate + tRNAGln
AMP + diphosphate + L-glutamyl-tRNAGln
Thermosynechococcus vestitus
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tRNAGln is initially mischarged with glutamate by a non-discriminating glutamyl-tRNA synthetase
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-
?
ATP + L-glutamate + tRNAGlu
AMP + diphosphate + L-glutamyl-tRNAGlu
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-
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?
ATP + L-glutamate + tRNAGlu
AMP + diphosphate + L-glutamyl-tRNAGlu
Thermosynechococcus vestitus
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-
-
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?
ATP + L-glutamate + tRNAGlx
AMP + diphosphate + Glu-tRNAGlx
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the enzyme is responsible for the in vivo aminoacylation of both tRNAGlu and tRNAGln in Bacillus subtilis
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?
ATP + L-glutamate + tRNAGlx
AMP + diphosphate + Glu-tRNAGlx
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the enzyme aminoacylates both tRNAGlu and tRNAGln because Rhizobium meliloti contains no glutaminyl-tRNAGln ligase
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?
ATP + L-glutamate + tRNAGlx
AMP + diphosphate + Glu-tRNAGlx
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the enzyme is capable of mischarging plastidal tRNAGln from barley with glutamate as well as regularly charges the plastidal tRNAGlu from Scenedesmus. The mischarged glutamyl-tRNAGln is subsequently amidated by glutamyl-tRNA amidotransferase to form the glutaminyl-tRNAGln required for plastidal protein biosynthesis
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?
additional information
?
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ND-GluRS recognizes both tRNAGlu and tRNAGln without significantly discriminating between them, tRNA discrimination module, overview. The first point of significant distinction between the GlnRS and ND-GluRS tRNA recognition involves residues contacting the G36 nucleobase. A second distiction involves a beta-hairpin module in the CP domain
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-
?
additional information
?
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the glutamyl residue of Glu-tRNAGln is then transamidated by a glutamyl-tRNAGln amidotransferase (Glu-AdT) in the presence of ATP using Gln as an amide donor, producing GlntRNAGln, coupled reaction assay
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-
?
additional information
?
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the glutamyl residue of Glu-tRNAGln is then transamidated by a glutamyl-tRNAGln amidotransferase (Glu-AdT) in the presence of ATP using Gln as an amide donor, producing GlntRNAGln, coupled reaction assay
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?
additional information
?
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ND-GluRS TM1875 glutamylates both tRNAGlu and tRNAGln
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?
additional information
?
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ND-GluRS TM1875 glutamylates both tRNAGlu and tRNAGln
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?
