6.1.1.24: glutamate-tRNAGln ligase

This is an abbreviated version!
For detailed information about glutamate-tRNAGln ligase, go to the full flat file.

Word Map on EC 6.1.1.24

6.1.1.24

glutaminyl-trna

aminoacylation

gln-trnagln

trnaglu

aminoacyl-trnas

synthetases

amidotransferase

glutamylates

archaea

transamidation

gatcab

anticodons

thermautotrophicus

glutaminylated

methanothermobacter

mischarged

apicoplast

isoacceptors

glurss

eukarya

anticodon-binding

berghei

heterotrimeric

arc1p

lupinus

luteus

misaminoacylated

noncognate

drug development

Reaction

Synonyms

Glu-Q-RS, GluRS, GluRS1, GluRS2, GluRSND, glutamyl-queuosine tRNAAsp synthetase, Glutamyl-tRNA synthetase, GlxRS, ND-GluRS, non-discriminating GluRS, non-discriminating glutamyl-tRNA synthetase, nondiscriminating GluRS, nondiscriminating glutamyl-tRNA synthetase, Pf3D7_1357200, TM1875

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.24 glutamate-tRNAGln ligase

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Results	in table
76	AA Sequence
1	Application
1	CAS Registry Number
15	Cloned(Commentary)
7	Cofactor
6	Crystallization (Commentary)
8	General Information
1	General Stability
1	Inhibitors
3	kcat/KM [mM/s]
1	Ki Value [mM]
20	KM Value [mM]
4	Localization
6	Metals/Ions
2	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
30	Organism
5	Pathway
3	pH Optimum
11	Protein Variants
8	Purification (Commentary)
3	Reaction
1	Reaction Type
28	Reference
1	Specific Activity [micromol/min/mg]
60	Substrates and Products (Substrate)
7	Subunits
38	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
13	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.1.1.24 - glutamate-tRNAGln ligase

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L-glutamate:tRNAGlx ligase (AMP-forming)

When this enzyme acts on tRNAGlu, it catalyses the same reaction as EC 6.1.1.17, glutamate---tRNA ligase. It has, however, diminished discrimination, so that it can also form glutamyl-tRNAGln. This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon [1]. This accounts for the ability of this enzyme in, for example, Bacillus subtilis, to recognize both tRNA1Gln (UUG anticodon) and tRNAGlu (UUC anticodon) but not tRNA2Gln (CUG anticodon). The ability of this enzyme to recognize both tRNAGlu and one of the tRNAGln isoacceptors derives from their sharing a major identity element, a hypermodified derivative of U34 (5-methylaminomethyl-2-thiouridine). The glutamyl-tRNAGln is not used in protein synthesis until it is converted by EC 6.3.5.7, glutaminyl-tRNA synthase (glutamine-hydrolysing), into glutaminyl-tRNAGln.