6.1.1.16: cysteine-tRNA ligase

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For detailed information about cysteine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.16

6.1.1.16

synthetases

aminoacyl-trnas

aminoacylation

cys-trnacys

prolyl-trna

prors

seprs

cysteinyl-trnacys

asnrs

atp-ppi

ilers

valrs

o-phosphoseryl-trna

maripaludis

aarss

sep-trna:cys-trna

sepcyss

o-phosphoserine

drug development

molecular biology

medicine

Reaction

Synonyms

CarS, CARS1, CARS2, class I CysRS, class I cysteinyl-tRNA synthetase, CRS, CysRS, cysS, Cysteine translase, Cysteine--tRNA ligase, cysteine-specific aminoacyl-tRNA synthetase, cysteinyl tRNA synthetase, Cysteinyl-transfer ribonucleate synthetase, Cysteinyl-transfer RNA synthetase, Cysteinyl-tRNA synthetase, MSMEG_6074, Synthetase, cysteinyl-transfer ribonucleate

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.16 cysteine-tRNA ligase

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Results	in table
1	Activating Compound
51334	AA Sequence
4	Application
1	CAS Registry Number
11	Cloned(Commentary)
19	Cofactor
3	Crystallization (Commentary)
24	Disease/ Diagnostics
10	General Information
1	General Stability
74	Inhibitors
11	kcat/KM [mM/s]
107	KM Value [mM]
7	Localization
24	Metals/Ions
18	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
63	Organism
4	Pathway
8	PDB ID
9	pH Optimum
1	pH Range
1	pH Stability
49	Protein Variants
22	Purification (Commentary)
3	Reaction
18	Reaction Type
57	Reference
13	Source Tissue
15	Specific Activity [micromol/min/mg]
3	Storage Stability
117	Substrates and Products (Substrate)
14	Subunits
108	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
68	Turnover Number [1/s]

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Application on EC 6.1.1.16 - cysteine-tRNA ligase

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drug development

2 entries

medicine

Homo sapiens

in order to evaluate genetic associations between candidate genes involved in oxidative stress and multiple system atrophy (MSA) 119 Japanese patients with MSA and 123 controls are examined and single-nucleotide polymorphisms are genotyped. Results revealed genetic associations of cysteinyl-tRNA synthetase, solute carrier family 1A4, sequestosome 1, and eukaryotic translation initiation factor 4E-binding protein 1 with MSA

694292

molecular biology

Mycoplasma hyopneumoniae

Mycoplasmas hyopneumoniae are collected from bronchial alveolar lavage samples of infected pigs 28 days postinfection and compared to broth-grown cells using microarrays. During lung infection, the analysis indicates that 79 genes are differentially expressed. Of the down-regulated genes, 28 of 46 (61%) lacked an assigned function, in comparison to 21 of 33 (63%) of up-regulated genes. Cysteinyl-tRNA synthetase is down-regulated in vivo

692603