6.1.1.12: aspartate-tRNA ligase

This is an abbreviated version!
For detailed information about aspartate-tRNA ligase, go to the full flat file.

Reaction

Synonyms

Antigen T5, AsnRS, Asp-RS, ASPA, Aspartate--tRNA ligase, Aspartic acid translase, Aspartyl ribonucleate synthetase, Aspartyl ribonucleic synthetase, aspartyl ribonuleic synthetase, Aspartyl-transfer ribonucleic acid synthetase, Aspartyl-transfer RNA synthetase, Aspartyl-tRNA synthetase, AspRS, AspS, Bt cyt-AspRS, cytoplasmic aspartyl-tRNA synthetase, D-AspRS, DARS2, discriminating aspartyl-tRNA synthetase, discriminating AspRS, DRS, Drs2, Ec AspRS, HS cyt-AspRS, Hs mt-AspRS, hsAspRS, IBI1, mAspRS, mitochondrial aspartyl-tRNA synthetase, mmAspRS, mt-AspRS, non-discriminating aspartyl-tRNA synthetase, non-discriminating AspRS, Pa AspRS, Synthetase, aspartyl-transfer ribonucleate, Tb-AspRS1, Tb-AspRS2, TK0492

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.12 aspartate-tRNA ligase

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Results	in table
6	Activating Compound
23762	AA Sequence
7	Application
1	CAS Registry Number
49	Cloned(Commentary)
36	Cofactor
22	Crystallization (Commentary)
168	Disease/ Diagnostics
3	General Information
1	General Stability
2	IC50 Value
54	Inhibitors
10	kcat/KM [mM/s]
20	Ki Value [mM]
99	KM Value [mM]
22	Localization
25	Metals/Ions
34	Molecular Weight [Da]
79	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
482	Organism
4	Pathway
51	PDB ID
31	pH Optimum
3	pH Range
1	pI Value
3	Posttranslational Modification
96	Protein Variants
48	Purification (Commentary)
19	Reaction
51	Reaction Type
116	Reference
1	Renatured (Commentary)
53	Source Tissue
38	Specific Activity [micromol/min/mg]
4	Storage Stability
190	Substrates and Products (Substrate)
43	Subunits
266	Synonyms
1	Systematic Name
27	Temperature Optimum [°C]
3	Temperature Range [°C]
13	Temperature Stability [°C]
49	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 6.1.1.12 - aspartate-tRNA ligase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0499

1-[(5E)-5-[(2,4-dichlorophenyl)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide

Mycobacterium tuberculosis

P9WFW3

at pH 7.6 and 37°C

746254

0.0591

ethyl 1-[(5E)-5-[(4-chlorophenyl)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxylate

Mycobacterium tuberculosis

P9WFW3

at pH 7.6 and 37°C

746254