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6.1.1.12: aspartate-tRNA ligase

This is an abbreviated version!
For detailed information about aspartate-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.12

Reaction

ATP
+
L-aspartate
+
tRNAAsp
=
AMP
+
diphosphate
+
L-aspartyl-tRNAAsp

Synonyms

Antigen T5, AsnRS, Asp-RS, ASPA, Aspartate--tRNA ligase, Aspartic acid translase, Aspartyl ribonucleate synthetase, Aspartyl ribonucleic synthetase, aspartyl ribonuleic synthetase, Aspartyl-transfer ribonucleic acid synthetase, Aspartyl-transfer RNA synthetase, Aspartyl-tRNA synthetase, AspRS, AspS, Bt cyt-AspRS, cytoplasmic aspartyl-tRNA synthetase, D-AspRS, DARS2, discriminating aspartyl-tRNA synthetase, discriminating AspRS, DRS, Drs2, Ec AspRS, HS cyt-AspRS, Hs mt-AspRS, hsAspRS, IBI1, mAspRS, mitochondrial aspartyl-tRNA synthetase, mmAspRS, mt-AspRS, non-discriminating aspartyl-tRNA synthetase, non-discriminating AspRS, Pa AspRS, Synthetase, aspartyl-transfer ribonucleate, Tb-AspRS1, Tb-AspRS2, TK0492

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.12 aspartate-tRNA ligase

KM Value

KM Value on EC 6.1.1.12 - aspartate-tRNA ligase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
8
2-aminomalonic acid
-
ATP-diphosphate exchange
0.003 - 4.6
Asp
1.2 - 1.4
aspartate
0.03
aspartic acid
pH 7.2, 70°C
0.023 - 1.11
ATP
0.0015 - 0.21
L-aspartate
0.005
L-aspartic acid
pH 7.2, 70°C
24
threo-3-hydroxyaspartic acid
-
ATP-diphosphate exchange
0.000063 - 0.0091
tRNAAsn
0.000013 - 0.08
tRNAAsp
1.3
tRNAAspA73
-
pH 7.8, 28°C
-
additional information
additional information
-