5.4.99.9: UDP-galactopyranose mutase
This is an abbreviated version!
For detailed information about UDP-galactopyranose mutase, go to the full flat file.
Word Map on EC 5.4.99.9
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5.4.99.9
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phosphoglycerate
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methylmalonic
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methylmalonyl-coa
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udp-galactofuranose
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galactofuranose
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chorismate
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urogenital
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udp-galf
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acidemia
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galf
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adenosylcobalamin
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methylmalonyl-coenzyme
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sinus
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prephenate
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acidurias
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succinyl-coa
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b12-dependent
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2,3-bisphosphoglycerate
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bisphosphoglycerate
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flavoenzyme
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adocbl
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cobalamin-dependent
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propionyl-coa
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adenosylcobalamin-dependent
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drug development
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isobutyryl-coa
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cofactor-dependent
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shermanii
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cytodifferentiation
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methylcobalamin
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phosphoenzyme
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cobiialamin
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analysis
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medicine
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synthesis
- 5.4.99.9
- phosphoglycerate
-
methylmalonic
- methylmalonyl-coa
- udp-galactofuranose
-
galactofuranose
- chorismate
-
urogenital
-
udp-galf
- acidemia
-
galf
- adenosylcobalamin
-
methylmalonyl-coenzyme
-
sinus
- prephenate
- acidurias
- succinyl-coa
-
b12-dependent
- 2,3-bisphosphoglycerate
-
bisphosphoglycerate
-
flavoenzyme
-
adocbl
-
cobalamin-dependent
- propionyl-coa
-
adenosylcobalamin-dependent
- drug development
- isobutyryl-coa
-
cofactor-dependent
- shermanii
-
cytodifferentiation
- methylcobalamin
- phosphoenzyme
-
cobiialamin
- analysis
- medicine
- synthesis
Reaction
Synonyms
AfUGM, ANIA_03112, CdUGM, galactopyranose mutase, Glf, GLF gene product, GLF-1, glfA, MtUGM, mutase, Mutase, uridine diphosphogalactopyranose, TcUGM, UDP galactopyranose mutase, UDP-D-galactopyranose mutase, UDP-Gal mutase, UDP-galactopyranose mutase, UDP-Galp mutase, UGM, UgmA, UNGM, uridine 5'-diphosphate galactopyranose mutase, uridine 5'-diphosphate galactopyranosemutase, uridine 5'-diphosphate-galactopyranose mutase, uridine diphosphate galactopyranose mutase
ECTree
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Application
Application on EC 5.4.99.9 - UDP-galactopyranose mutase
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analysis
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high-throughput fluorescence polarization assay for indentification of inhibitors of enzyme and homologues
drug development
medicine
the UDP-galactopyranose mutase is an appealing adjunct therapeutic target in combination with other drugs against Aspergillus fumigatus
synthesis
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production of uridine 5'-(trihydrogen diphosphate) P'-alpha-D-galactofuranosyl ester, a precursor required for the formation of the lipopolysaccharide O-antigen of Klebsiella pneumoniae serotype O1
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blocking the incorporation of the product galactofuranose into polysaccharides essential for pathogen viability or virulence may lead to novel therapeutics
drug development
the product galactofuranose is valued as an important target for the development of new antituberculosis drugs
drug development
the product galactofuranose is valued as an important target for the development of new antituberculosis drugs
drug development
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UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence
drug development
UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence
drug development
UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence
drug development
UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence
drug development
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inhibitors of the enzyme that block the biosynthesis of UDP-galactofuranose can lead to novel chemotherapeutics for treating Aspergillus fumigatus-related diseases
drug development
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since the enzyme does not exist in Homo sapiens, the parasite enzyme is a target for drug design
drug development
the enzyme is a potential drug target involved in the synthesis of the cell wall of this fungal pathogen
drug development
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since the enzyme is not present in mammals, it is a promising target for the design of drugs to treat the Chagas' disease caused by Trypanosoma cruzi in humans
drug development
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the enzyme is a cell surface virulence factor in protozoan parasites and absent in humans, it is therefore a good drug target
drug development
the enzyme is a cell surface virulence factor in protozoan parasites and absent in humans, it is therefore a good drug target
drug development
the enzyme is a cell surface virulence factor in protozoan parasites and absent in humans, it is therefore a good drug target
drug development
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UDP-galactopyranose mutase (UGM), a key enzyme in the biosynthesis of mycobacterial cell walls, is a potential target for the treatment of tuberculosis