5.4.3.11: phenylalanine aminomutase (D-beta-phenylalanine forming)
This is an abbreviated version!
For detailed information about phenylalanine aminomutase (D-beta-phenylalanine forming), go to the full flat file.
Word Map on EC 5.4.3.11
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5.4.3.11
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pantoea
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synthesis
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agglomerans
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unnatural
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taxus
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stereochemistry
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isomerizes
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isomerization
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drug development
- 5.4.3.11
- pantoea
- synthesis
- agglomerans
-
unnatural
- taxus
-
stereochemistry
-
isomerizes
-
isomerization
- drug development
Reaction
Synonyms
admH, EncP, HitA, methylidene imidazolone-dependent phenylalanine aminomutase, MIO-dependent phenylalanine ammonia lyase, PAM, PaPAM, phenylalanine 2,3-aminomutase, phenylalanine aminomutase, phenylalanine-2,3-aminomutase
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General Information on EC 5.4.3.11 - phenylalanine aminomutase (D-beta-phenylalanine forming)
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
malfunction
metabolism
physiological function
PaPAM makes the (3S)-beta-phenylalanine antipode on the biosynthetic pathway to the antibiotic andrimid starting from (S)-beta-phenylalanine via (S)-alpha-phenylalanine
additional information
evolution
phenylalanine 2,3-mutases, PAMs, belong to the class I lyase-like family that includes tyrosine 2,3-aminomutases (TAMs), tyrosine ammonia-lyases (TALs), and histidine ammonia-lyases (HALs). All these enzymes rely on a protein-derived cofactor, 4-methylideneimidazol-5-one (MIO), which is generated autocatalytically from three active site residues, Ala-Ser-Gly (Thr-Ser-Gly in PaPAM), forming a MIO signature motif
evolution
the enzyme belongs to a class I lyase-like superfamily of catalysts, along with other MIO-dependent aminomutases
malfunction
a hitA knockout mutant shows no hitachimycin production, but antibiotic production is restored by feeding with (S)-beta-Phe
malfunction
Embleya scabrispora JCM 11712 / DSM 41855
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a hitA knockout mutant shows no hitachimycin production, but antibiotic production is restored by feeding with (S)-beta-Phe
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metabolism
the enzyme is important in the hitachimycin biosynthetic pathway. A plausible biosynthetic pathway for hitachimycin, including a unique polyketide skeletal transformation mechanism, is proposed
metabolism
Embleya scabrispora JCM 11712 / DSM 41855
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the enzyme is important in the hitachimycin biosynthetic pathway. A plausible biosynthetic pathway for hitachimycin, including a unique polyketide skeletal transformation mechanism, is proposed
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additional information
enzyme structure-activity analysis and modeling of substrate-PaPAM structural interactions, overview
additional information
molecular modelling of the covalent enzyme-substrate N-MIO complexes in PaPAM
