5.4.3.11: phenylalanine aminomutase (D-beta-phenylalanine forming)
This is an abbreviated version!
For detailed information about phenylalanine aminomutase (D-beta-phenylalanine forming), go to the full flat file.
Word Map on EC 5.4.3.11
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5.4.3.11
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pantoea
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synthesis
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agglomerans
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unnatural
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taxus
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stereochemistry
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isomerizes
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isomerization
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drug development
- 5.4.3.11
- pantoea
- synthesis
- agglomerans
-
unnatural
- taxus
-
stereochemistry
-
isomerizes
-
isomerization
- drug development
Reaction
Synonyms
admH, EncP, HitA, methylidene imidazolone-dependent phenylalanine aminomutase, MIO-dependent phenylalanine ammonia lyase, PAM, PaPAM, phenylalanine 2,3-aminomutase, phenylalanine aminomutase, phenylalanine-2,3-aminomutase
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Cofactor
Cofactor on EC 5.4.3.11 - phenylalanine aminomutase (D-beta-phenylalanine forming)
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MIO, a protein-derived cofactor, which is generated autocatalytically from three active site residues, Ala-Ser-Gly (Thr-Ser-Gly in PaPAM), forming a MIO signature motif
4-methylidene-1H-imidazol-5(4H)-one
MIO, prosthetic group, dependent on
4-methylidene-1H-imidazol-5(4H)-one
MIO, prosthetic group, dependent on, proposed elimination mechanisms for the displacement of the NH2-MIO adduct. Formation of an NH2-MIO adduct, where the amino group of the substrate is covalently attached to the enzyme during alpha/beta-isomerization