5.4.3.11: phenylalanine aminomutase (D-beta-phenylalanine forming)

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For detailed information about phenylalanine aminomutase (D-beta-phenylalanine forming), go to the full flat file.

Word Map on EC 5.4.3.11

5.4.3.11

pantoea

synthesis

agglomerans

unnatural

taxus

stereochemistry

isomerizes

isomerization

drug development

Reaction

Synonyms

admH, EncP, HitA, methylidene imidazolone-dependent phenylalanine aminomutase, MIO-dependent phenylalanine ammonia lyase, PAM, PaPAM, phenylalanine 2,3-aminomutase, phenylalanine aminomutase, phenylalanine-2,3-aminomutase

ECTree

5 Isomerases

5.4 Intramolecular transferases

5.4.3 Transferring amino groups

5.4.3.11 phenylalanine aminomutase (D-beta-phenylalanine forming)

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Results	in table
2	Activating Compound
24	AA Sequence
4	Application
7	Cloned(Commentary)
3	Cofactor
1	Crystallization (Commentary)
9	General Information
1	General Stability
24	kcat/KM [mM/s]
25	KM Value [mM]
1	Metals/Ions
5	Natural Substrates/ Products (Substrates)
12	Organism
4	pH Optimum
1	pH Stability
5	Protein Variants
4	Purification (Commentary)
3	Reaction
1	Reaction Type
11	Reference
53	Substrates and Products (Substrate)
2	Subunits
28	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
4	Temperature Stability [°C]
24	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 5.4.3.11 - phenylalanine aminomutase (D-beta-phenylalanine forming)

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L-phenylalanine 2,3-aminomutase [(S)-3-amino-3-phenylpropanoate]

The enzyme from the bacterium Pantoea agglomerans produces D-beta-phenylalanine, an intermediate in the biosynthesis of the polyketide non-ribosomal antibiotic andrimid. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine. cf. EC 5.4.3.10, phenylalanine aminomutase (L-beta-phenylalanine forming).