5.3.3.5: cholestenol DELTA-isomerase
This is an abbreviated version!
For detailed information about cholestenol DELTA-isomerase, go to the full flat file.
Word Map on EC 5.3.3.5
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5.3.3.5
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ebp
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x-linked
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chondrodysplasia
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punctata
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stipple
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sigma1
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epiphyseal
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x-inactivation
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8-dehydrocholesterol
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nsdhl
- 5.3.3.5
- ebp
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x-linked
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chondrodysplasia
- punctata
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stipple
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sigma1
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epiphyseal
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x-inactivation
- 8-dehydrocholesterol
- nsdhl
Reaction
Synonyms
3beta-hydroxysteroid DELTA8,7-sterol isomerase, 3beta-hydroxysteroid DELTA8-DELTA7 isomerase, 8,7SI, C-8,7 sterol isomerase, Cholestenol delta-isomerase, D8-D7 sterol isomerase, D8D7I, DELTA8,7-isomerase, DELTA8,7-sterol isomerase, DELTA8-Cholestenol-DELTA7-cholestenol isomerase, DELTA8-DELTA7 isomerase, Delta8-delta7 sterol isomerase, DELTA8-SI, EBP, Emopamil binding protein, emopamil-binding protein, ERG2p, HSI, Isomerase, cholestenol DELTA-, SI, SI1, sterol 8,7-isomerase, sterol DELTA8 isomerase
ECTree
5.3.3.5 cholestenol DELTA-isomeraseAdvanced search results
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results (Substrates Products
Substrates Products on EC 5.3.3.5 - cholestenol DELTA-isomerase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
26,27-dinorcholesta-8,24-dienol
26,27-dinorcholesta-7,24-dienol
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?
26-homo-cholesta-8(9),23(24) E26(26')-trienol
26-homo-cholesta-7(8),23(24)E26(26')trienol
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?
4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol
24-methylenelophenol
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-
i.e. 4alpha-methyl-5alpha-ergosta-7,24-dien-3beta-ol
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?
5alpha-cholest-7-en-3beta-ol
?
enzyme of the cholesterol biosynthetic pathway, mutations are associated with Conradi-Huenermann syndrome. The enzyme may be involved in liver function, since the mRNA is only detected in hepatocytes not in connective tissue or blood vessels. The expression of the SI gene is regulated transcriptionally in vitro and in vivo by widely known regulatory agents ranging from tamoxifen, an oestrogen receptor antagonist and SI-specific inhibitor, to cholesterol-lowering drugs
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?
5alpha-cholesta-8,24-dien-3beta-ol
5alpha-cholesta-7,24-dien-3beta-ol
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?
zymosterol
cholesta-7,24-dienol
preferred substrate for DELTA7-sterol production, the reaction equilibrium for double-bond isomerization favours the forward direction, DELTA8 to DELTA7
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r
additional information
?
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3-desoxyzymosterol is not an active substrate
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?
