Cloned (Comment) | Organism |
---|---|
the full-length cDNA that complements the erg2 mutation contains an open reading frame encoding a 21000 Da protein that shares 68% similarity and 35% amino acid identity to the recently isolated mouse C8,7 sterol isomerase | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | functional complementation by C-8,7 sterol isomerase of the corresponding sterol mutant in yeast and its characterization by exposure to sigma ligands. The full-length Arabidosis thaliana cDNA encoding C-8,7 sterol isomerase complements the erg2 mutation | Arabidopsis thaliana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
haloperidol | - |
Arabidopsis thaliana | |
ifenprodil | - |
Arabidopsis thaliana | |
verapamil | - |
Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | putative transmembrane spanning domains | Arabidopsis thaliana | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
21000 | - |
x * 21000, about, sequence calculation | Arabidopsis thaliana |
26737 | - |
x * 26737, calculation from nucleotide sequence | Arabidopsis thaliana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol | - |
Arabidopsis thaliana | 24-methylenelophenol | i.e. 4alpha-methyl-5alpha-ergosta-7,24-dien-3beta-ol | ? |
Subunits | Comment | Organism |
---|---|---|
? | x * 26737, calculation from nucleotide sequence | Arabidopsis thaliana |
? | x * 21000, about, sequence calculation | Arabidopsis thaliana |
Synonyms | Comment | Organism |
---|---|---|
C-8,7 sterol isomerase | - |
Arabidopsis thaliana |
SI1 | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in the ergosterol production. Pharmacological relationship between sigma ligand-binding and C-8,7 sterol isomerase activity, the C-8,7 sterol isomerase that contains a sigma ligand binding site | Arabidopsis thaliana |