5.3.2.1: phenylpyruvate tautomerase
This is an abbreviated version!
For detailed information about phenylpyruvate tautomerase, go to the full flat file.
Word Map on EC 5.3.2.1
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5.3.2.1
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necrosis
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monocyte
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tnf
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endothelial
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lymphocyte
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chemokine
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autoimmune
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anti-mif
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glucocorticoid
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arthritis
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pulmonary
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artery
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leukocyte
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angiogenesis
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sepsis
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rheumatoid
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tnf-alpha
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lipopolysaccharide
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factor-alpha
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myocardial
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t-cells
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atherosclerosis
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chemotactic
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c-reactive
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pituitary
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chemoattractant
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infarct
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lupus
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lymphokine
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toll-like
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autocrine
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cxcr2
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synovial
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ifn-gamma
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il-1beta
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counter-regulator
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chemokine-like
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erythematosus
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immunoregulatory
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cell-mediated
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glomerulonephritis
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dehalogenation
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tautomerization
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counterregulates
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delayed-type
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pro-tumorigenic
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drug development
- 5.3.2.1
- necrosis
- monocyte
- tnf
- endothelial
- lymphocyte
- chemokine
- autoimmune
-
anti-mif
- glucocorticoid
- arthritis
- pulmonary
- artery
- leukocyte
- angiogenesis
- sepsis
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rheumatoid
- tnf-alpha
- lipopolysaccharide
- factor-alpha
- myocardial
- t-cells
- atherosclerosis
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chemotactic
-
c-reactive
- pituitary
-
chemoattractant
- infarct
-
lupus
- lymphokine
-
toll-like
-
autocrine
- cxcr2
-
synovial
- ifn-gamma
- il-1beta
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counter-regulator
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chemokine-like
- erythematosus
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immunoregulatory
-
cell-mediated
- glomerulonephritis
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dehalogenation
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tautomerization
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counterregulates
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delayed-type
-
pro-tumorigenic
- drug development
Reaction
Synonyms
CaaD, CCH2, cis-3-chloroacrylic acid dehalogenase, cis-CaaD, Macrophage migration inhibitory factor, macrophage migration inhibitory factor tautomerase, MIF, MIF tautomerase, phenyl(enol)pyruvate tautomerase, Phenylpyruvate keto-enol tautomerase, Phenylpyruvic keto-enol isomerase, PPT, Tautomerase, phenylpyruvate, trans-3-chloroacrylic acid dehalogenase
ECTree
5.3.2.1 phenylpyruvate tautomeraseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 5.3.2.1 - phenylpyruvate tautomerase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
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the enzyme is chemotactic for human monocytes and activates them to produce IL-8, TNF-alpha and endogenous MIF
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?
additional information
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the enzyme is chemotactic for human monocytes and activates them to produce IL-8, TNF-alpha and endogenous MIF
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?
additional information
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important immunoregulatory molecule with a unique ability to suppress the anti-inflammatory effects of glucocorticoids
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?
additional information
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MIF is a homotrimeric multifunctional proinflammatory cytokine. It also shows dopachrome tautomerase activity. Binding of MIF to its receptor, CD74, overview
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?
additional information
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the MIF protein is multifunctional, exhibiting besides its tautomerase activity, e.g. also L-dopachrome isomerase activity, EC 5.3.3.12, and thioredoxin-like function, or its cytokine function, overview
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?
additional information
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the enzymatic activity of macrophage migration inhibitory factor does not play a role in its migration inhibiting properties. Macrophage migration inhibitory factor is an inhibitor of the random migration of monocytes and macrophages and has since been proposed to have a number of immune and catalytic functions, macrophage migration inhibitory factor is an inhibitor of monocyte chemoattractant protein 1-induced chemotaxis of human peripheral blood monocytes
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