5.3.2.1: phenylpyruvate tautomerase

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For detailed information about phenylpyruvate tautomerase, go to the full flat file.

Word Map on EC 5.3.2.1

5.3.2.1

necrosis

monocyte

tnf

endothelial

lymphocyte

chemokine

autoimmune

anti-mif

glucocorticoid

arthritis

pulmonary

artery

leukocyte

angiogenesis

sepsis

rheumatoid

tnf-alpha

lipopolysaccharide

factor-alpha

myocardial

t-cells

atherosclerosis

chemotactic

c-reactive

pituitary

chemoattractant

infarct

lupus

lymphokine

toll-like

autocrine

cxcr2

synovial

ifn-gamma

il-1beta

counter-regulator

chemokine-like

erythematosus

immunoregulatory

cell-mediated

glomerulonephritis

dehalogenation

tautomerization

counterregulates

delayed-type

pro-tumorigenic

drug development

Reaction

Synonyms

CaaD, CCH2, cis-3-chloroacrylic acid dehalogenase, cis-CaaD, Macrophage migration inhibitory factor, macrophage migration inhibitory factor tautomerase, MIF, MIF tautomerase, phenyl(enol)pyruvate tautomerase, Phenylpyruvate keto-enol tautomerase, Phenylpyruvic keto-enol isomerase, PPT, Tautomerase, phenylpyruvate, trans-3-chloroacrylic acid dehalogenase

ECTree

5 Isomerases

5.3 Intramolecular oxidoreductases

5.3.2 Interconverting keto- and enol-groups

5.3.2.1 phenylpyruvate tautomerase

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Results	in table
71	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
6	Crystallization (Commentary)
5780	Disease/ Diagnostics
1	Expression
4	General Information
87	IC50 Value
163	Inhibitors
8	kcat/KM [mM/s]
9	Ki Value [mM]
40	KM Value [mM]
1	Localization
17	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
46	Organism
3	Pathway
305	PDB ID
2	pH Optimum
22	Protein Variants
8	Purification (Commentary)
1	Reaction
3	Reaction Type
36	Reference
27	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
74	Substrates and Products (Substrate)
21	Subunits
35	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
40	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 5.3.2.1 - phenylpyruvate tautomerase

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-10°C, stable for several months

Sus scrofa

2870

-20°C, 6 weeks, no loss of activity

Sus scrofa

2869

4°C, protein from homogenated tissue heated to 58°C for 20 min, and subsequently salted out of the supernatant with ammonium sulfate to the final saturation of 80% can be stored six months without loss of activity

Bos taurus

678357