5.3.2.1: phenylpyruvate tautomerase
This is an abbreviated version!
For detailed information about phenylpyruvate tautomerase, go to the full flat file.
Word Map on EC 5.3.2.1
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5.3.2.1
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necrosis
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monocyte
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tnf
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endothelial
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lymphocyte
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chemokine
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autoimmune
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anti-mif
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glucocorticoid
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arthritis
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pulmonary
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artery
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leukocyte
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angiogenesis
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sepsis
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rheumatoid
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tnf-alpha
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lipopolysaccharide
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factor-alpha
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myocardial
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t-cells
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atherosclerosis
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chemotactic
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c-reactive
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pituitary
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chemoattractant
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infarct
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lupus
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lymphokine
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toll-like
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autocrine
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cxcr2
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synovial
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ifn-gamma
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il-1beta
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counter-regulator
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chemokine-like
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erythematosus
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immunoregulatory
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cell-mediated
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glomerulonephritis
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dehalogenation
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tautomerization
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counterregulates
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delayed-type
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pro-tumorigenic
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drug development
- 5.3.2.1
- necrosis
- monocyte
- tnf
- endothelial
- lymphocyte
- chemokine
- autoimmune
-
anti-mif
- glucocorticoid
- arthritis
- pulmonary
- artery
- leukocyte
- angiogenesis
- sepsis
-
rheumatoid
- tnf-alpha
- lipopolysaccharide
- factor-alpha
- myocardial
- t-cells
- atherosclerosis
-
chemotactic
-
c-reactive
- pituitary
-
chemoattractant
- infarct
-
lupus
- lymphokine
-
toll-like
-
autocrine
- cxcr2
-
synovial
- ifn-gamma
- il-1beta
-
counter-regulator
-
chemokine-like
- erythematosus
-
immunoregulatory
-
cell-mediated
- glomerulonephritis
-
dehalogenation
-
tautomerization
-
counterregulates
-
delayed-type
-
pro-tumorigenic
- drug development
Reaction
Synonyms
CaaD, CCH2, cis-3-chloroacrylic acid dehalogenase, cis-CaaD, Macrophage migration inhibitory factor, macrophage migration inhibitory factor tautomerase, MIF, MIF tautomerase, phenyl(enol)pyruvate tautomerase, Phenylpyruvate keto-enol tautomerase, Phenylpyruvic keto-enol isomerase, PPT, Tautomerase, phenylpyruvate, trans-3-chloroacrylic acid dehalogenase
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Subunits
Subunits on EC 5.3.2.1 - phenylpyruvate tautomerase
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heterohexamer
homotrimer
trimer
?
x * 12335, electrospray ionization mass spectrometry, mutant enzyme P1G
?
x * 12347, electrospray ionization mass spectrometry, mutant enzyme N97A
?
x * 12347, electrospray ionization mass spectrometry, mutant enzyme P1A
?
x * 12358, electrospray ionization mass spectrometry, mutant enzyme Y95F
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3 * 16093, electrospray ionization mass spectrometry
homotrimer
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3 * 16093, electrospray ionization mass spectrometry
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the tertiary structure is stabilized by hydrogen bonds and a hydrophobic core, three beta-sheets and six alpha-helices surround a traversing channel with dominant positive charge in the middle of the trimer, structure, overview. The enzyme contains a Cys-Xaa-Xaa-Cys motif required for oxido-reductase activity and MIF-like activities like glucorticoid overriding and cell proliferation
trimer
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trimer formation is required for MIF tautomerase activity, trimer three-dimensional structure and tautomerase active site structure. The subunit interface is not as hydrophobic as the interior of the monomer, however, there is a hydrophobic patch on the surface involving residues Y36, Y95, W108, and F113, MALDI-TOF and analytical gel filtration analysis, overview