5.3.2.1: phenylpyruvate tautomerase
This is an abbreviated version!
For detailed information about phenylpyruvate tautomerase, go to the full flat file.
Word Map on EC 5.3.2.1
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5.3.2.1
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necrosis
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monocyte
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tnf
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endothelial
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lymphocyte
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chemokine
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autoimmune
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anti-mif
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glucocorticoid
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arthritis
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pulmonary
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artery
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leukocyte
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angiogenesis
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sepsis
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rheumatoid
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tnf-alpha
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lipopolysaccharide
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factor-alpha
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myocardial
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t-cells
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atherosclerosis
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chemotactic
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c-reactive
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pituitary
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chemoattractant
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infarct
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lupus
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lymphokine
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toll-like
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autocrine
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cxcr2
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synovial
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ifn-gamma
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il-1beta
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counter-regulator
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chemokine-like
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erythematosus
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immunoregulatory
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cell-mediated
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glomerulonephritis
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dehalogenation
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tautomerization
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counterregulates
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delayed-type
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pro-tumorigenic
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drug development
- 5.3.2.1
- necrosis
- monocyte
- tnf
- endothelial
- lymphocyte
- chemokine
- autoimmune
-
anti-mif
- glucocorticoid
- arthritis
- pulmonary
- artery
- leukocyte
- angiogenesis
- sepsis
-
rheumatoid
- tnf-alpha
- lipopolysaccharide
- factor-alpha
- myocardial
- t-cells
- atherosclerosis
-
chemotactic
-
c-reactive
- pituitary
-
chemoattractant
- infarct
-
lupus
- lymphokine
-
toll-like
-
autocrine
- cxcr2
-
synovial
- ifn-gamma
- il-1beta
-
counter-regulator
-
chemokine-like
- erythematosus
-
immunoregulatory
-
cell-mediated
- glomerulonephritis
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dehalogenation
-
tautomerization
-
counterregulates
-
delayed-type
-
pro-tumorigenic
- drug development
Reaction
Synonyms
CaaD, CCH2, cis-3-chloroacrylic acid dehalogenase, cis-CaaD, Macrophage migration inhibitory factor, macrophage migration inhibitory factor tautomerase, MIF, MIF tautomerase, phenyl(enol)pyruvate tautomerase, Phenylpyruvate keto-enol tautomerase, Phenylpyruvic keto-enol isomerase, PPT, Tautomerase, phenylpyruvate, trans-3-chloroacrylic acid dehalogenase
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General Information
General Information on EC 5.3.2.1 - phenylpyruvate tautomerase
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malfunction
physiological function
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MIF expression contributes to cell proliferation, invasiveness and neo-angiogenesis of neuroblastoma, gastric, hepatocellularbladder, and breast carcinomas. MIF takes part in the pathogenesis of Alzheimer's disease and multiple sklerosis
malfunction
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MIF is implicated in the pathogenesis of several inflammatory and autoimmune diseases
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MIF is involved in diverse biological processes, e.g. MIF glucocorticoid overriding activity, endotoxin lipopolysaccharide-induced TNF production, MIF-mediated stimulation of ERK1/2 MAP kinase and proliferation of serum-starved cells, MIF-mediated upregulation of arachidonic acid in macrophages, and Cox-2 activation
physiological function
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MIF plays an essential role in both, innate and adaptive immune response. It is implicated in tumor growth and angiogenesis, an exerts an antagonistic effect against glucocorticoid immunosuppressive action, and shows glucorticoid overriding activity