5.3.1.9: glucose-6-phosphate isomerase
This is an abbreviated version!
For detailed information about glucose-6-phosphate isomerase, go to the full flat file.
Word Map on EC 5.3.1.9
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5.3.1.9
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gpi
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hexokinase
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phosphoglucomutase
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fructose
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aldolase
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phosphofructokinase
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malate
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6-phosphogluconate
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arthritis
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pentose
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erythrocyte
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metastasis
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allozyme
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starch
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rheumatoid
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isocitrate
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enolase
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phosphoglycerate
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infestans
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phytophthora
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glyceraldehyde-3-phosphate
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mating
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glucokinase
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triosephosphate
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fructose-6-phosphate
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hemolytic
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isomerases
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malic
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blight
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triose
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chimaera
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glucose-6-phosphatase
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butterfly
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monomorphic
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fructose-1,6-bisphosphate
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zymodeme
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autotaxin
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1,6-bisphosphate
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fructokinase
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starch-gel
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drug development
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nonspherocytic
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1.1.1.49
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embden-meyerhof
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sporangia
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2.7.1.1
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tumor-secreted
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erythrose
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fructose-6-p
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phosphomannose
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analysis
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medicine
- 5.3.1.9
- gpi
- hexokinase
- phosphoglucomutase
- fructose
- aldolase
-
phosphofructokinase
- malate
- 6-phosphogluconate
- arthritis
- pentose
- erythrocyte
- metastasis
-
allozyme
- starch
-
rheumatoid
- isocitrate
- enolase
- phosphoglycerate
- infestans
- phytophthora
- glyceraldehyde-3-phosphate
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mating
- glucokinase
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triosephosphate
- fructose-6-phosphate
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hemolytic
- isomerases
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malic
- blight
- triose
- chimaera
- glucose-6-phosphatase
- butterfly
-
monomorphic
- fructose-1,6-bisphosphate
-
zymodeme
- autotaxin
- 1,6-bisphosphate
- fructokinase
-
starch-gel
- drug development
-
nonspherocytic
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1.1.1.49
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embden-meyerhof
-
sporangia
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2.7.1.1
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tumor-secreted
- erythrose
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fructose-6-p
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phosphomannose
- analysis
- medicine
Reaction
Synonyms
6-Phosphoglucose isomerase, AfcPGI, AMF, AMF/PGI, At4g24620, autocrine motility factor, autocrine motility factor/phosphoglucose isomerase, Cupin-PGI, D-Glucose-6-phosphate isomerase, D-glucose-6-phosphate ketol-isomerase, G6-PI, Glucose 6-phosphate isomerase, Glucose phosphate isomerase, Glucose phosphoisomerase, glucose-6-phosphate isomerase, glucose-6-phosphate isomerase, cytosolic, Glucosephosphate isomerase 2, GPI, Hexose 6-phosphate isomerase, Hexose isomerase, Hexose monophosphate isomerase, Hexose phosphate isomerase, Hexosephosphate isomerase, Isomerase, glucose phosphate, Neuroleukin, NLK, Oxoisomerase, PGI, PGI/AMF, Pgi1, PGI2, PGI3, pgiA, PHI, Phosphoglucoisomerase, Phosphoglucose isomerase, phosphoglucose isomerase/autocrine motility factor, Phosphohexoisomerase, Phosphohexomutase, Phosphohexose isomerase, Phosphosaccharomutase, SA-36, Sperm antigen-36, SwoM, TK1111, VEG54, Vegetative protein 54
ECTree
5.3.1.9 glucose-6-phosphate isomeraseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 5.3.1.9 - glucose-6-phosphate isomerase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2-amino-2-deoxy-D-glucitol 6-phosphate
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
2-amino-2-deoxy-D-glucitol 6-phosphate dimethyl ester
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
2-amino-2-deoxy-D-mannitol 6-phosphate
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
2-Deoxy-D-glucitol 6-phosphate
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
5-phospho-D-arabinoamide
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
5-phospho-D-arabinoate
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
5-phospho-D-arabinohydroxamate
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
5-phospho-D-arabinonohydroxamate
competitive, stable analogue of putative cis-endiol intermediate
6-phospho-D-gluconate
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
6-phospho-D-gluconoamide
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
Co2+
10 mM, 59% inhibition, D-fructose 6-phosphate as substrate
D-glucitol 6-phosphate
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
GTP
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competitive inhibitor, also compromises the autocrine motility factor function of the enzyme. The GTP-binding site partially overlaps with the catalytic site. In addition,GTP stabilizes the structure of PGI against heat- and detergent-induced denaturation. GTP is bound in a syn-conformation with the gamma-phosphate group located near the phosphate-binding loop and the ribose moiety positioned away from the active-site residues
insulin-like growth factor binding protein-3
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both glycosylated and unglycosylated, binding and inhibition of enzyme
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N-acetyl-2-amino-2-deoxy-D-glucitol 6-phosphate
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comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase
Cd2+
10 mM, 96% inhibition, D-fructose 6-phosphate as substrate
Cu2+
10 mM, 96% inhibition, D-fructose 6-phosphate as substrate
D-fructose 1,6-bisphosphate
10 mM, residual activities are 41% and 53% in the direction of fructose 6-phosphate and glucose 6-phosphate formation, respectively
D-Fructose 1-phosphate
2 mM, residual activities are 50% and 69% in the direction of fructose 6-phosphate and glucose 6-phosphate formation, respectively
D-mannose 6-phosphate
1.25 mM, residual activities are 18% and 38% in the direction of fructose 6-phosphate and glucose 6-phosphate formation, respectively
EDTA
100fold excess, complete loss of activity within 10 min. 93% of activity may be recovered by additon of 1000fold excess of Zn2+
EDTA
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the enzyme activity is completely diminished when the enzyme is heated at 70°C in the presence of 10 mM EDTA. Complete restoration of the enzyme activity is observed when the enzyme is incubated at room temperature in the presence of Zn2+
EDTA
10 mM, 78% inhibition, D-fructose 6-phosphate as substrate
erythrose 4-phosphate
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activates enzyme form B with ribose 5-phosphate as substrate, inhibits activity of enzyme form A and B with glucose 6-phosphate as substrate, inhibits activity of enzyme form A with glucose 6-phosphate as substrate
Mn2+
10 mM, 18% inhibition, D-fructose 6-phosphate as substrate
Ni2+
10 mM, 84% inhibition, D-fructose 6-phosphate as substrate
Zn2+
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plastid enzyme is completely inhibited by 5 mM, activity of cytosolic isoenzyme is reduced to 49% of untreated control
Zn2+
10 mM, 89% inhibition, D-fructose 6-phosphate as substrate
additional information
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screening for thiazolide inhibitors, diverse compounds, mode of action of thiazolides and structure-activity relationship, overview
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additional information
activity is not affected by addition of 10 mM EDTA. The addition of fructose, glucose, mannose, galactose (10 mM), pyruvate, phosphoenolpyruvate (10 mM), AMP, ADP, or ATP (3.5 mM), does not show any effect on the activity neither in the fructose 6-phosphate formation, nor in the glucose 6-phosphate formation
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additional information
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activity is not affected by addition of 10 mM EDTA. The addition of fructose, glucose, mannose, galactose (10 mM), pyruvate, phosphoenolpyruvate (10 mM), AMP, ADP, or ATP (3.5 mM), does not show any effect on the activity neither in the fructose 6-phosphate formation, nor in the glucose 6-phosphate formation
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additional information
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no inhibition by suramin, an anti-trypanosomal drug, and agaricic acid
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