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5.1.3.13: dTDP-4-dehydrorhamnose 3,5-epimerase

This is an abbreviated version!
For detailed information about dTDP-4-dehydrorhamnose 3,5-epimerase, go to the full flat file.

Word Map on EC 5.1.3.13

Reaction

dTDP-4-dehydro-6-deoxy-alpha-D-glucose
=
dTDP-4-dehydro-beta-L-rhamnose

Synonyms

3,5-epimerase, Agl13, bifunctional UDP-4-keto-6-deoxy-D-glucose epimerase/reductase, C14F11.6, deoxythymidine diphosphate-4-dehydrorhamnose 3,5-epimerase, deoxythymidine diphospho-4-keto-6-deoxyglucose 3,5-epimerase, DnmU, dTDP-4-dehydro-6-deoxy-glucose-3,5-epimerase, dTDP-4-dehydrorhamnose 3,5-epimerase, dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase, dTDP-4-keto-6-deoxyglucose 3,5-epimerase, dTDP-4-keto-L-rhamnose 3,5-epimerase, dTDP-6-deoxy-D-xylo-4-hexulose 3',5'-epimerase, dTDP-L-rhamnose synthetase, Epimerase, thymidine diphospho-4-ketorhamnose 3,5-, NovW gene product, RfbC, RmbC, rml-3, RmlC, TDP-4-keto-6-deoxy-D-glucose 3,5-epimerase, TDP-4-keto-L-rhamnose-3,5-epimerase, TDP-4-ketorhamnose 3,5-epimerase, TDP-6-deoxy-D-xylo-4-hexopyranosid-4-ulose 3,5-epimerase, Thymidine diphospho-4-ketorhamnose 3,5-epimerase, UGER

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.3 Acting on carbohydrates and derivatives
                5.1.3.13 dTDP-4-dehydrorhamnose 3,5-epimerase

Inhibitors

Inhibitors on EC 5.1.3.13 - dTDP-4-dehydrorhamnose 3,5-epimerase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(3-(5-allyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfonyl)-propyl)-1H-benzo[d]imidazol-2(3H)-one
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1-(3-(5-allyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one
i.e. 77074, a SID 7975595 analogue
1-(3-(5-allyl-8-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one
-
1-(3-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfonyl)-propyl)-1H-benzo[d]imidazol-2(3H)-one
-
1-(3-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one
i.e. SID 7975595, a competitive, fast-on rate, fully reversible inhibitor of RmlC. Increases the Km for TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose. Cytotoxic SID 7975595 has an IC50 of approximately 0.075 mM in HAE cells
1-(3-(5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one
i.e. 77072, a SID 7975595 analogue
1-(3-(5-methylphenyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one
i.e. 77070, a SID 7975595 analogue
1-(3-(5-propyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one
i.e. 77071, a SID 7975595 analogue
1-(3-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one
i.e. 77073, a SID 7975595 analogue
additional information
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