5.1.3.13: dTDP-4-dehydrorhamnose 3,5-epimerase

This is an abbreviated version!
For detailed information about dTDP-4-dehydrorhamnose 3,5-epimerase, go to the full flat file.

Word Map on EC 5.1.3.13

5.1.3.13

4,6-dehydratase

o-antigen

deoxysugars

glucose-1-phosphate

dtdp-d-glucose

dtmp

medicine

dtdp-rhamnose

synthesis

Reaction

Synonyms

3,5-epimerase, Agl13, bifunctional UDP-4-keto-6-deoxy-D-glucose epimerase/reductase, C14F11.6, deoxythymidine diphosphate-4-dehydrorhamnose 3,5-epimerase, deoxythymidine diphospho-4-keto-6-deoxyglucose 3,5-epimerase, DnmU, dTDP-4-dehydro-6-deoxy-glucose-3,5-epimerase, dTDP-4-dehydrorhamnose 3,5-epimerase, dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase, dTDP-4-keto-6-deoxyglucose 3,5-epimerase, dTDP-4-keto-L-rhamnose 3,5-epimerase, dTDP-6-deoxy-D-xylo-4-hexulose 3',5'-epimerase, dTDP-L-rhamnose synthetase, Epimerase, thymidine diphospho-4-ketorhamnose 3,5-, NovW gene product, RfbC, RmbC, rml-3, RmlC, TDP-4-keto-6-deoxy-D-glucose 3,5-epimerase, TDP-4-keto-L-rhamnose-3,5-epimerase, TDP-4-ketorhamnose 3,5-epimerase, TDP-6-deoxy-D-xylo-4-hexopyranosid-4-ulose 3,5-epimerase, Thymidine diphospho-4-ketorhamnose 3,5-epimerase, UGER

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.3 Acting on carbohydrates and derivatives

5.1.3.13 dTDP-4-dehydrorhamnose 3,5-epimerase

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Results	in table
29027	AA Sequence
6	Application
1	CAS Registry Number
12	Cloned(Commentary)
5	Cofactor
6	Crystallization (Commentary)
27	General Information
9	IC50 Value
10	Inhibitors
7	KM Value [mM]
1	Localization
2	Metals/Ions
8	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
221	Organism
11	Pathway
90	PDB ID
5	pH Optimum
6	Protein Variants
8	Purification (Commentary)
3	Reaction
5	Reaction Type
29	Reference
6	Source Tissue
32	Substrates and Products (Substrate)
6	Subunits
55	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
6	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 5.1.3.13 - dTDP-4-dehydrorhamnose 3,5-epimerase

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dTDP-4-dehydro-6-deoxy-alpha-D-glucose

dTDP-4-dehydro-beta-L-rhamnose

8 entries

dTDP-4-dehydro-6-deoxy-D-glucose

Streptomyces griseus

enzyme in biosynthesis of dTDP-L-dihydrostreptose from dTDP-6-deoxy-D-xylo-4-hexosulose

2253

dTDP-4-dehydro-6-deoxy-D-glucose

dTDP-4-dehydro-L-rhamnose

Komagataeibacter xylinus

the enzyme is involved in the dTDP-rhamnose synthesis pathway which consists of three steps: (i) the synthesis of dTDP-4-keto-6-deoxy-D-glucose from glucose 1-phosphate and dTDP, (ii) the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-L-rhamnose by dTDP-4-dehydrorhamnose 3,5-epimerase and (iii) the reduction of dTDP-4-keto-L-rhamnose to dTDP-L-rhamnose. The mutant K3 strain, with a spontaneous mutation that results in lower cellulose production, shows deoxythymidine diphosphate-4-dehydrorhamnose 3,5-epimerase activity, while the wild-type does not, determined by 2D-gel electrophoresis. It is possible that in the wild-type, transcription of the gene responsible for the expression of dTDP-4-dehydrorhamnose 3,5-epimerase is repressed by a transcription factor, and that a mutation in the gene encoding the transcription factor has rendered it non-functional

703046

dTDP-6-deoxy-D-xylo-4-hexulose

dTDP-6-deoxy-L-lyxo-4-hexulose

4 entries

TDP-6-deoxy-D-xylo-4-hexosulose

4 entries

TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose

TDP-L-rhamnose

Mycobacterium tuberculosis

P9WH11

conversion of TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose to TDP-L-rhamnose, catalyzed by the two enzymes TDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase, RmlC, and TDP-deoxy-L-lyxo-4-hexulose reductase, RmlD, overview

702695

additional information

2 entries