4.3.1.B2: imidazole glycerol phosphate synthase

This is an abbreviated version!
For detailed information about imidazole glycerol phosphate synthase, go to the full flat file.

Word Map on EC 4.3.1.B2

4.3.1.B2

glutaminase

ammonia

amidotransferase

maritima

thermotoga

allostery

cyclase

prfar

ribonucleotide

heterodimeric

bienzyme

aicar

millisecond

5-aminoimidazole-4-carboxamide

betaalpha8-barrels

v-type

half-barrels

timescale

ribotide

Reaction

Synonyms

HIS7, IGP synthase, IGPS, ImGP synthase

ECTree

4 Lyases

4.3 Carbon-nitrogen lyases

4.3.1 Ammonia-lyases

4.3.1.B2 imidazole glycerol phosphate synthase

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Results	in table
1	AA Sequence
5	Cloned(Commentary)
4	Crystallization (Commentary)
7	General Information
8	Inhibitors
64	kcat/KM [mM/s]
7	Ki Value [mM]
68	KM Value [mM]
8	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
104	Organism
9	pH Optimum
2	pH Range
31	Protein Variants
8	Purification (Commentary)
6	Reaction
15	Reference
1	Source Tissue
1	Storage Stability
34	Substrates and Products (Substrate)
5	Subunits
9	Synonyms
7	Temperature Optimum [°C]
1	Temperature Stability [°C]
65	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 4.3.1.B2 - imidazole glycerol phosphate synthase

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L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate

L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

5 entries

N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine

L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Escherichia coli

P60595; P60664

for the IGP synthase holoenzyme L-glutamine is a more efficient substrate relative to ammonium ion by a factor of 1000. The HisF subunit alone does not ulilize L-glutamine. It supports an ammonia-dependent reaction with a turnover number similar to that of the holoenzyme with glutamine

726928

D-erythro-1-(imidazol-4-yl)glycerol phosphate i.e. (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-4-yl)propyl phosphate. 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide i.e. [(2R,3S,4R,5R)-5-(4-carbamoyl-5-aminoimidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate i.e. AICAR