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4.3.1.B2: imidazole glycerol phosphate synthase

This is an abbreviated version!
For detailed information about imidazole glycerol phosphate synthase, go to the full flat file.

Word Map on EC 4.3.1.B2

Reaction

L-glutamine
+
H2O
=
L-glutamate
+
NH3

Synonyms

HIS7, IGP synthase, IGPS, ImGP synthase

ECTree

     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.B2 imidazole glycerol phosphate synthase

Inhibitors

Inhibitors on EC 4.3.1.B2 - imidazole glycerol phosphate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-diazo-5-oxo-L-norleucine
-
acivicin
albizziin
mixed type inhibition versus N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate, competitive inhibition versus L-glutamine
MgCl2
10 mM, activity is reduced by 22%
MnCl2
10 mM, activity is reduced by 58%
N1-[(5'-phosphoarabinitolyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
competitive versus N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate, mixed type inhibition versus L-glutamine
N1-[(5'-phosphoribitolyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
competitive versus N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate