4.3.1.B2: imidazole glycerol phosphate synthase
This is an abbreviated version!
For detailed information about imidazole glycerol phosphate synthase, go to the full flat file.
Word Map on EC 4.3.1.B2
-
4.3.1.B2
-
glutaminase
-
ammonia
-
amidotransferase
-
maritima
-
thermotoga
-
allostery
-
cyclase
-
prfar
-
ribonucleotide
-
heterodimeric
-
bienzyme
-
aicar
-
millisecond
-
5-aminoimidazole-4-carboxamide
-
betaalpha8-barrels
-
v-type
-
half-barrels
-
timescale
-
ribotide
- 4.3.1.B2
- glutaminase
- ammonia
-
amidotransferase
- maritima
-
thermotoga
-
allostery
- cyclase
-
prfar
- ribonucleotide
-
heterodimeric
-
bienzyme
- aicar
-
millisecond
- 5-aminoimidazole-4-carboxamide
-
betaalpha8-barrels
-
v-type
-
half-barrels
-
timescale
- ribotide
Reaction
Synonyms
HIS7, IGP synthase, IGPS, ImGP synthase
ECTree
4.3.1.B2 imidazole glycerol phosphate synthaseAdvanced search results
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results (KM Value
KM Value on EC 4.3.1.B2 - imidazole glycerol phosphate synthase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0015
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-monophosphate
pH 8.5, 25°C
0.00027 - 0.24
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
1 - 4.5
L-glutamine
pH 8.0, 30°C, IGP synthase enzyme with a E46G mutant subunit HisF
1.3
L-glutamine
pH 7.0, 30°C, cosubstrate: N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate, mutant enzyme R239K
1.8
L-glutamine
pH 7.0, 30°C, cosubstrate: N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate, wild-type enzyme
1.9
L-glutamine
pH 7.0, 30°C, cosubstrate: N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate, mutant enzyme K258R
1.9
L-glutamine
pH 7.0, 30°C, cosubstrate: N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate, mutant enzyme K360R
1.96
L-glutamine
pH 7.0, 30°C, cosubstrate: N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate, mutant enzyme K360A
2.1
L-glutamine
pH 7.0, 30°C, cosubstrate: N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate, mutant enzyme R239H
5.4
L-glutamine
pH 8.0, 30°C, IGP synthase enzyme with a R5H mutant subunit HisF
6.5
L-glutamine
pH 7.0, 30°C, cosubstrate: N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate, mutant enzyme K258A
6.5
L-glutamine
pH 7.0, 30°C, cosubstrate: N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate, mutant enzyme R239A
0.00027
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: L-glutamine, mutant enzyme K196A
0.0013
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: L-glutamine, mutant enzyme N13A
0.0016
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: L-glutamine, mutant enzyme R239K
0.0018
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: L-glutamine, mutant enzyme K360A
0.002
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: L-glutamine, mutant enzyme K258R
0.002
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
-
pH 8.0, 25°C, cosubstrate: L-glutamine, wild-type enzyme
0.0023
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: L-glutamine, mutant enzyme K360R
0.0028
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
-
pH 8.0, 25°C, cosubstrate: L-glutamine, HisH/HisF holoenzyme with a T78M mutant subunit HisF
0.003
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: L-glutamine, mutant enzyme R239A
0.0036
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
-
pH 8.0, 25°C, cosubstrate: NH4+, wild-type enzyme
0.0036
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: L-glutamine, mutant enzyme Q397A
0.004
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C
0.005
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: L-glutamine, wild-type enzyme
0.005
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: L-glutamine, wild-type enzyme
0.0055
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: L-glutamine, mutant enzyme D359A
0.0059
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
-
pH 8.0, 25°C, cosubstrate: NH4+, HisH/HisF holoenzyme with a T78M mutant subunit HisF
0.008
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: L-glutamine, mutant enzyme R239H
0.0125
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, IGP synthase enzyme with a E46G mutant subunit HisF
0.0141
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: L-glutamine, mutant enzyme K196A/D359A
0.0175
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, IGP synthase enzyme with a Q123R mutant subunit HisF
0.021
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, HisF subunit, saturating concentrations of ammonium chloride can not be achieved due to inhibition of the enzyme activity at chloride ion concentrations
0.0218
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, IGP synthase enzyme with a C124R mutant subunit HisF
0.026
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: NH4+, mutant enzyme K196A/D359A
0.03
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: NH4+, mutant enzyme Q397A
0.034
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: NH4+, mutant enzyme K196A
0.0426
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, IGP synthase enzyme with a R5H mutant subunit HisF
0.046
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: NH4+, mutant enzyme K258R
0.053
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: NH4+, mutant enzyme R239A
0.055
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: NH4+, wild-type enzyme
0.055
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: NH4+, wild-type enzyme
0.065
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: NH4+, mutant enzyme K360A
0.071
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: NH4+, mutant enzyme N13A
0.072
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: NH4+, mutant enzyme K360R
0.075
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: NH4+, mutant enzyme R239H
0.08
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: NH4+, mutant enzyme R239K
0.098
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: L-glutamine, mutant enzyme K258A
0.109
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, cosubstrate: NH4+, mutant enzyme D359A
0.139
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 7.0, 30°C, cosubstrate: NH4+, mutant enzyme K258A
0.24
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
pH 8.0, 30°C, IGP synthase holoenzyme
1 - 1.2
NH4+
pH 8.0, 30°C, IGP synthase enzyme with a E46G mutant subunit HisF
7.4
NH4+
pH 8.0, 30°C, IGP synthase enzyme with a C124R mutant subunit HisF
13.4
NH4+
pH 8.0, 30°C, IGP synthase enzyme with a Q123R mutant subunit HisF
14.3
NH4+
pH 8.0, 30°C, IGP synthase enzyme with a R5H mutant subunit HisF
