4.3.1.17: L-serine ammonia-lyase
This is an abbreviated version!
For detailed information about L-serine ammonia-lyase, go to the full flat file.
Word Map on EC 4.3.1.17
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4.3.1.17
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aminotransferase
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pyridoxal
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deamination
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glucagon
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gluconeogenesis
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gluconeogenic
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hydroxymethyltransferase
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l-isoleucine
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d-serine
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plp-dependent
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peptostreptococcus
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deaminases
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2-oxobutyrate
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asaccharolyticus
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analysis
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medicine
- 4.3.1.17
- aminotransferase
- pyridoxal
-
deamination
- glucagon
-
gluconeogenesis
-
gluconeogenic
- hydroxymethyltransferase
- l-isoleucine
- d-serine
-
plp-dependent
-
peptostreptococcus
- deaminases
- 2-oxobutyrate
- asaccharolyticus
- analysis
- medicine
Reaction
Synonyms
bsLSD type 1, cSDH, Dehydratase, L-serine, EC 4.2.1.13, GSU0486, HSDH, L-Hydroxy amino acid dehydratase, L-SD, L-SD1, L-SD2, L-serine ammonia-lyase, L-Serine deaminase, L-serine deaminase 2, L-serine dehydratase, L-serine dehydratase 1, L-serine dehydratase 2, L-threonine deaminase, L-threonine dehydratase, lpLSD, lpLSD type 2, More, MSMEG_3532, PH0054, SD, SdaA, SdaB, SDH, SDH-like-1, SDH1, SDH2, SdhA, SerDH, Serine deaminase, Serine dehydratase, serine dehydratase like-1, tdcB, TdcG
ECTree
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Systematic Name
Systematic Name on EC 4.3.1.17 - L-serine ammonia-lyase
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L-serine ammonia-lyase (pyruvate-forming)
Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead [6]. The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.13, L-serine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond. The latter reaction, which can occur spontaneously, is also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. This reaction is also carried out by EC 4.3.1.19, threonine ammonia-lyase, from a number of sources.