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4.3.1.17: L-serine ammonia-lyase

This is an abbreviated version!
For detailed information about L-serine ammonia-lyase, go to the full flat file.

Word Map on EC 4.3.1.17

Reaction

2-aminoprop-2-enoate
=
2-iminopropanoate

Synonyms

bsLSD type 1, cSDH, Dehydratase, L-serine, EC 4.2.1.13, GSU0486, HSDH, L-Hydroxy amino acid dehydratase, L-SD, L-SD1, L-SD2, L-serine ammonia-lyase, L-Serine deaminase, L-serine deaminase 2, L-serine dehydratase, L-serine dehydratase 1, L-serine dehydratase 2, L-threonine deaminase, L-threonine dehydratase, lpLSD, lpLSD type 2, More, MSMEG_3532, PH0054, SD, SdaA, SdaB, SDH, SDH-like-1, SDH1, SDH2, SdhA, SerDH, Serine deaminase, Serine dehydratase, serine dehydratase like-1, tdcB, TdcG

ECTree

     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.17 L-serine ammonia-lyase

Inhibitors

Inhibitors on EC 4.3.1.17 - L-serine ammonia-lyase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
2-oxobutyrate
20 mM: 49.3% inhibition, not reversed by 5 mM AMP
AlK(SO4)2
-
-
ammonia
product inhibition, noncompetitive
Cu2+
inhibition of both activities
CuCl2
-
0.7 mM, 50% inhibition
D-Ser
D-serine
ethanolamine
Fe2+
slight inhibition of both activities
glyoxylate
20 mM: 54.1% inhibition, not reversed by 5 mM AMP
homocysteine
-
noncompetitive with respect to substrate, competitive with regard to pyridoxal 5'-phosphate
hydroxylamine
-
-
imidazole
-
-
L-Ala
L-alanine
-
-
L-Cys
L-cysteine
L-Thr
-
competitive
L-threonine
-
100 mM, 56% inhibition
L-Trp
NH4Cl
-
significant fall in the serine-dehydratase expression during experimental chronic acidosis, acidosis is induced by ingestion of 0.28 M ammonium chloride solution
oxygen
pyruvate
Zn2+
inhibition of both activities
additional information
-