4.3.1.17: L-serine ammonia-lyase

This is an abbreviated version!
For detailed information about L-serine ammonia-lyase, go to the full flat file.

Reaction

Synonyms

bsLSD type 1, cSDH, Dehydratase, L-serine, EC 4.2.1.13, GSU0486, HSDH, L-Hydroxy amino acid dehydratase, L-SD, L-SD1, L-SD2, L-serine ammonia-lyase, L-Serine deaminase, L-serine deaminase 2, L-serine dehydratase, L-serine dehydratase 1, L-serine dehydratase 2, L-threonine deaminase, L-threonine dehydratase, lpLSD, lpLSD type 2, More, MSMEG_3532, PH0054, SD, SdaA, SdaB, SDH, SDH-like-1, SDH1, SDH2, SdhA, SerDH, Serine deaminase, Serine dehydratase, serine dehydratase like-1, tdcB, TdcG

ECTree

     4 Lyases

         4.3 Carbon-nitrogen lyases

             4.3.1 Ammonia-lyases

                4.3.1.17 L-serine ammonia-lyase

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Results	in table
4	Activating Compound
35908	AA Sequence
3	Application
1	CAS Registry Number
14	Cloned(Commentary)
33	Cofactor
8	Crystallization (Commentary)
89	Disease/ Diagnostics
2	General Information
5	General Stability
1	IC50 Value
72	Inhibitors
24	kcat/KM [mM/s]
7	Ki Value [mM]
83	KM Value [mM]
3	Localization
32	Metals/Ions
66	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
90	Organism
6	Oxidation Stability
8	Pathway
49	PDB ID
24	pH Optimum
5	pH Range
6	pH Stability
1	pI Value
43	Protein Variants
37	Purification (Commentary)
7	Reaction
5	Reaction Type
84	Reference
27	Source Tissue
32	Specific Activity [micromol/min/mg]
10	Storage Stability
139	Substrates and Products (Substrate)
30	Subunits
90	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
1	Temperature Range [°C]
13	Temperature Stability [°C]
42	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 4.3.1.17 - L-serine ammonia-lyase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

ATP

Mus musculus

-

-

662359

leucine

Rattus norvegicus

P09367

excess leucine intake strongly induces SDH activity in the liver but not in the kidney

678810

sulfhydryl reagents

Clostridium acidi-urici

-

required

210786

additional information

Escherichia coli

-

the enzyme is inactive in crude extract and can be activated with iron and dithiothreitol. The activation requires oxygen, and is inhibited by free radical scavengers and by diethylenentriamine pentaacetic acid, which prevents Fe cycling

210796

-