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4.2.3.17: taxadiene synthase

This is an abbreviated version!
For detailed information about taxadiene synthase, go to the full flat file.

Word Map on EC 4.2.3.17

Reaction

geranylgeranyl diphosphate
=
taxa-4,11-diene
 +
diphosphate

Synonyms

geranylgeranyl pyrophosphate cyclase, taxa-4(5),11(12)-diene synthase, taxadiene synthase, taxadiene synthase 5, TXS

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.17 taxadiene synthase

Activating Compound

Activating Compound on EC 4.2.3.17 - taxadiene synthase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-hydroxyethyl jasmonate
the transcription level of the TS gene is up-regulated in response to exogenous 2-hydroxyethyl jasmonate, HEJ
methyl jasmonate
the transcription level of the TS gene is up-regulated in response to exogenous methyl jasmonate, MJ
taxol
-
exogenous Taxol (paclitaxel) causes an considerable increase in taxadiene synthase activity, the expression level peaks at day 4 with a rapid decrease at day 8, reaching a second, lower, peak at day 12. By day 16, ts mRNA is only detectable in the untreated control at a very low level. The concentration of taxol that most effectively induces ts mRNA expression is 50 mg/l compared to the control, the transcript levels are 2.5-, 3.1- and 3.3fold higher at 4, 8 and 12 days of culture.
additional information
-
coexpression of geranylgeranyl diphosphate synthase gene from Sulfolobus acidocaldarius and codon optimzing of the Taxus chinensis taxadiene synthase gene increases the production of taxadiene in Saccharomyces cerevisiae
-