4.2.3.17: taxadiene synthase
This is an abbreviated version!
For detailed information about taxadiene synthase, go to the full flat file.
Word Map on EC 4.2.3.17
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4.2.3.17
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taxus
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paclitaxel
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taxane
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brevifolia
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tx
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diterpene
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diterpenoids
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taxoids
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carbocation
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medicine
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10-deacetylbaccatin
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baccata
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taxol-producing
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cuspidata
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mairei
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ggpps
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synthesis
-
drug development
- 4.2.3.17
- taxus
- paclitaxel
-
taxane
- brevifolia
- tx
-
diterpene
-
diterpenoids
-
taxoids
-
carbocation
- medicine
-
10-deacetylbaccatin
- baccata
-
taxol-producing
- cuspidata
- mairei
- ggpps
- synthesis
- drug development
Reaction
Synonyms
geranylgeranyl pyrophosphate cyclase, taxa-4(5),11(12)-diene synthase, taxadiene synthase, taxadiene synthase 5, TXS
ECTree
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Crystallization
Crystallization on EC 4.2.3.17 - taxadiene synthase
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X-ray crystal structure of a truncation variant lacking the transit sequence and an additional 27 residues at the N-terminus, complexed with 13-aza-13,14-dihydrocopalyl diphosphate, at 1.82 A resolution, and 2-fluorogeranylgeranyl diphosphate, at 2.25 A resolution. The structure reveals a modular assembly of three alpha-helical domains. The C-terminal catalytic domain is a class I terpenoid cyclase, which binds and activates substrate GGPP with a three-metal ion cluster. The N-terminal domain and a third insertion domain together adopt the fold of a vestigial class II terpenoid cyclase