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4.2.3.17: taxadiene synthase

This is an abbreviated version!
For detailed information about taxadiene synthase, go to the full flat file.

Word Map on EC 4.2.3.17

Reaction

geranylgeranyl diphosphate
=
taxa-4,11-diene
 +
diphosphate

Synonyms

geranylgeranyl pyrophosphate cyclase, taxa-4(5),11(12)-diene synthase, taxadiene synthase, taxadiene synthase 5, TXS

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.17 taxadiene synthase

Crystallization

Crystallization on EC 4.2.3.17 - taxadiene synthase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
X-ray crystal structure of a truncation variant lacking the transit sequence and an additional 27 residues at the N-terminus, complexed with 13-aza-13,14-dihydrocopalyl diphosphate, at 1.82 A resolution, and 2-fluorogeranylgeranyl diphosphate, at 2.25 A resolution. The structure reveals a modular assembly of three alpha-helical domains. The C-terminal catalytic domain is a class I terpenoid cyclase, which binds and activates substrate GGPP with a three-metal ion cluster. The N-terminal domain and a third insertion domain together adopt the fold of a vestigial class II terpenoid cyclase