4.2.3.17: taxadiene synthase
This is an abbreviated version!
For detailed information about taxadiene synthase, go to the full flat file.
Word Map on EC 4.2.3.17
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4.2.3.17
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taxus
-
paclitaxel
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taxane
-
brevifolia
-
tx
-
diterpene
-
diterpenoids
-
taxoids
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carbocation
-
medicine
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10-deacetylbaccatin
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baccata
-
taxol-producing
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cuspidata
-
mairei
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ggpps
-
synthesis
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drug development
- 4.2.3.17
- taxus
- paclitaxel
-
taxane
- brevifolia
- tx
-
diterpene
-
diterpenoids
-
taxoids
-
carbocation
- medicine
-
10-deacetylbaccatin
- baccata
-
taxol-producing
- cuspidata
- mairei
- ggpps
- synthesis
- drug development
Reaction
Synonyms
geranylgeranyl pyrophosphate cyclase, taxa-4(5),11(12)-diene synthase, taxadiene synthase, taxadiene synthase 5, TXS
ECTree
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Reference on EC 4.2.3.17 - taxadiene synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hezari, M.; Ketchum, R.E.B.; Gibson, D.M.; Croteau, R.
Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures
Arch. Biochem. Biophys.
337
185-190
1997
Taxus brevifolia, Taxus canadensis
Wildung, M.R.; Croteau, R.
A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis
J. Biol. Chem.
271
9201-9204
1996
Taxus brevifolia (Q41594), Taxus brevifolia
Koepp, A.E.; Hezari, M.; Zajicek, J.; Stofer Vogel, B.; LaFever, R.; Lewis, N.G.; Croteau, R.
Cyclization of geranylgeranyl diphosphateto taxa-4(5),-11(12)-diene is the comitted step of taxol biosynthesis in pacific yew
J. Biol. Chem.
270
8686-8690
1995
Taxus brevifolia
Lin, X.; Hezari, M.; Koepp, A.E.; Floss, H.G.; Croteau, R.
Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in pacific yew
Biochemistry
35
2968-2977
1996
Taxus brevifolia
Williams, D.C.; Carroll, B.J.; Jin, Q.; Rithner, C.D.; Lenger, S.R.; Floss, H.G.; Coates, R.M.; Williams, R.M.; Croteau, R.
Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase
Chem. Biol.
7
969-977
2000
Taxus brevifolia
Williams, D.C.; Wildung, M.R.; Jin, A.Q.; Dalal, D.; Oliver, J.S.; Coates, R.M.; Croteau, R.
Heterologous xpression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction
Arch. Biochem. Biophys.
379
137-146
2000
Taxus brevifolia
Huang, Q.; Roessner, C.A.; Croteau, R.; Scott, A.I.
Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol
Bioorg. Med. Chem.
9
2237-2242
2001
Taxus brevifolia
Huang, Q.; Williams, H.J.; Roessner, C.A.; Scott, A.I.
Sesquiterpenes produced by truncated taxadiene synthase
Tetrahedron Lett.
41
9701-9704
2000
Taxus brevifolia
-
Jin, Y.; Williams, D.C.; Croteau, R.; Coates, R.M.
Taxadiene synthase-catalyzed cyclization of 6-fluorogeranylgeranyl diphosphate to 7-fluoroverticillenes
J. Am. Chem. Soc.
127
7834-7842
2005
Taxus brevifolia
Jin, Q.; Williams, D.C.; Hezari, M.; Croteau, R.; Coates, R.M.
Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling
J. Org. Chem.
70
4667-4675
2005
Taxus brevifolia
Chow, S.Y.; Williams, H.J.; Huang, Q.; Nanda, S.; Scott, A.I.
Studies on taxadiene synthase: interception of the cyclization cascade at the isocembrene stage with GGPP analogues
J. Org. Chem.
70
9997-10003
2005
Taxus brevifolia
Zhou, X.; Wang, Z.; Jiang, K.; Wei, Y.; Lin, J.; Sun, X.; Tang, K.
Screening of taxol-producing endophytic fungi from Taxus chinensis var. mairei
Appl. Biochem. Microbiol.
43
439-443
2007
Alternaria sp., Mucor sp., Ozonium
-
Hu, F.; Huang, J.; Xu, Y.; Qian, X.; Zhong, J.J.
Responses of defense signals, biosynthetic gene transcription and taxoid biosynthesis to elicitation by a novel synthetic jasmonate in cell cultures of Taxus chinensis
Biotechnol. Bioeng.
94
1064-1071
2006
Taxus chinensis (Q9FT37), Taxus chinensis
Chow, S.Y.; Williams, H.J.; Pennington, J.D.; Nanda, S.; Reibenspies, J.H.; Scott, A.I.
Studies on taxadiene synthase: interception of the cyclization cascade at the verticillene stage and rearrangement to phomactatriene
Tetrahedron
63
6204-6209
2007
Phoma sp.
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Kovacs, K.; Zhang, L.; Linforth, R.S.; Whittaker, B.; Hayes, C.J.; Fray, R.G.
Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit
Transgenic Res.
16
121-126
2007
Taxus baccata (Q93YA3)
Rontein, D.; Onillon, S.; Herbette, G.; Lesot, A.; Werck-Reichhart, D.; Sallaud, C.; Tissier, A.
CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the yclic ether 5(12)-oxa-3(11)-cyclotaxane
J. Biol. Chem.
283
6067-6075
2008
Taxus cuspidata
Engels, B.; Dahm, P.; Jennewein, S.
Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production
Metab. Eng.
10
201-206
2008
Taxus chinensis
Exposito, O.; Bonfill, M.; Onrubia, M.; Jane, A.; Moyano, E.; Cusido, R.M.; Palazon, J.; Pinol, M.T.
Effect of taxol feeding on taxol and related taxane production in Taxus baccata suspension cultures
N. Biotechnol.
25
252-259
2008
Taxus baccata
Staniek, A.; Woerdenbag, H.J.; Kayser, O.
Taxomyces andreanae: a presumed paclitaxel producer demystified?
Planta Med.
75
1561-1566
2009
Taxomyces andreanae, Taxomyces andreanae CBS 27992
Anterola, A.; Shanle, E.; Perroud, P.F.; Quatrano, R.
Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens
Transgenic Res.
18
655-660
2009
Taxus brevifolia
Koeksal, M.; Jin, Y.; Coates, R.M.; Croteau, R.; Christianson, D.W.
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis
Nature
469
116-120
2011
Taxus brevifolia (Q41594), Taxus brevifolia
Cha, M.; Shim, S.H.; Kim, S.H.; Kim, O.T.; Lee, S.W.; Kwon, S.Y.; Baek, K.H.
Production of taxadiene from cultured ginseng roots transformed with taxadiene synthase gene
BMB Rep.
45
589-594
2012
Taxus brevifolia (Q41594), Taxus brevifolia
Hasan, M.M.; Kim, H.S.; Jeon, J.H.; Kim, S.H.; Moon, B.; Song, J.Y.; Shim, S.H.; Baek, K.H.
Metabolic engineering of Nicotiana benthamiana for the increased production of taxadiene
Plant Cell Rep.
33
895-904
2014
Taxus brevifolia (Q41594), Taxus brevifolia
Edgar, S.; Li, F.S.; Qiao, K.; Weng, J.K.; Stephanopoulos, G.
Engineering of taxadiene synthase for improved selectivity and yield of a key taxol biosynthetic intermediate
ACS Synth. Biol.
6
201-205
2017
Taxus brevifolia (Q41594)
Freud, Y.; Ansbacher, T.; Major, D.
Catalytic control in the facile proton transfer in taxadiene synthase
ACS Catal.
7
7653-7657
2017
Taxus brevifolia (Q41594)
-
Pemberton, T.A.; Chen, M.; Harris, G.G.; Chou, W.K.; Duan, L.; Koeksal, M.; Genshaft, A.S.; Cane, D.E.; Christianson, D.W.
Exploring the influence of domain architecture on the catalytic function of diterpene synthases
Biochemistry
56
2010-2023
2017
Taxus brevifolia
Ansbacher, T.; Freud, Y.; Major, D.
Slow-starter enzymes role of active-site architecture in the catalytic control of the biosynthesis of taxadiene by taxadiene synthase
Biochemistry
57
3773-3779
2018
Taxus brevifolia, Taxus brevifolia (Q41594)
Li, M.; Jiang, F.; Yu, X.; Miao, Z.
Engineering isoprenoid biosynthesis in Artemisia annua L. for the production of taxadiene a key intermediate of taxol
BioMed Res. Int.
2015
504932
2015
Taxus brevifolia (Q41594)
Soliman, S.; Tang, Y.
Natural and engineered production of taxadiene with taxadiene synthase
Biotechnol. Bioeng.
112
229-235
2015
Taxus brevifolia
Escorcia, A.M.; van Rijn, J.P.M.; Cheng, G.J.; Schrepfer, P.; Brueck, T.B.; Thiel, W.
Molecular dynamics study of taxadiene synthase catalysis
J. Comput. Chem.
39
1215-1225
2018
Taxus brevifolia (Q41594)
Syklowska-Baranek, K.; Pilarek, M.; Bonfill, M.; Kafel, K.; Pietrosiuk, A.
Perfluorodecalin-supported system enhances taxane production in hairy root cultures of Taxus xxa0media var. Hicksii carrying a taxadiene synthase transgene
Plant Cell Tissue Organ Cult.
120
1051-1059
2015
Taxus baccata (Q6TBY0)
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