4.2.1.93: ATP-dependent NAD(P)H-hydrate dehydratase
This is an abbreviated version!
For detailed information about ATP-dependent NAD(P)H-hydrate dehydratase, go to the full flat file.
Word Map on EC 4.2.1.93
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4.2.1.93
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nadphx
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epimerase
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dehydrogenases
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febrile
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salvage
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neurometabolic
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epimer
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neurodevelopmental
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neurodegeneration
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protein-truncating
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reconvert
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apolipoprotein
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5'-phosphate
- 4.2.1.93
-
nadphx
-
epimerase
- dehydrogenases
-
febrile
-
salvage
-
neurometabolic
-
epimer
-
neurodevelopmental
-
neurodegeneration
-
protein-truncating
-
reconvert
-
apolipoprotein
- 5'-phosphate
Reaction
Synonyms
(S)-NAD(P)HX dehydratase, ADP-dependent (S)-NAD(P)H-hydrate dehydratase, ADP/ATP-dependent NAD(P)H-hydrate dehydratase, At5g19150, ATP-dependent H4NAD(P)OH dehydratase, ATP-dependent NNRD, BSU38720, Carkd, More, NAD(P)H-hydrate dehydratase, NAD(P)HX dehydratase, NAD(P)X dehydratase, NAXD, NNRD, reduced nicotinamide adenine dinucleotide hydrate dehydratase, YKL151C, YxkO
ECTree
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Systematic Name
Systematic Name on EC 4.2.1.93 - ATP-dependent NAD(P)H-hydrate dehydratase
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(6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing; NADH-forming)
Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers, and these are interconverted by EC 5.1.99.6, NAD(P)H-hydrate epimerase, to a 60:40 ratio [4]. Hence EC 4.2.1.93 together with EC 5.1.99.6 can restore the mixture of hydrates into NAD(P)H [3,4]. The enzyme from eukaryotes has no activity with ADP, contrary to the enzyme from bacteria (cf. EC 4.2.1.136, ADP-dependent NAD(P)H-hydrate dehydratase) [4].