4.2.1.93: ATP-dependent NAD(P)H-hydrate dehydratase

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For detailed information about ATP-dependent NAD(P)H-hydrate dehydratase, go to the full flat file.

Reaction

Synonyms

(S)-NAD(P)HX dehydratase, ADP-dependent (S)-NAD(P)H-hydrate dehydratase, ADP/ATP-dependent NAD(P)H-hydrate dehydratase, At5g19150, ATP-dependent H4NAD(P)OH dehydratase, ATP-dependent NNRD, BSU38720, Carkd, More, NAD(P)H-hydrate dehydratase, NAD(P)HX dehydratase, NAD(P)X dehydratase, NAXD, NNRD, reduced nicotinamide adenine dinucleotide hydrate dehydratase, YKL151C, YxkO

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.93 ATP-dependent NAD(P)H-hydrate dehydratase

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Results	in table
3761	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
8	Cofactor
12	Disease/ Diagnostics
1	Expression
37	General Information
4	kcat/KM [mM/s]
4	KM Value [mM]
30	Localization
6	Metals/Ions
4	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
22	Organism
2	Pathway
31	PDB ID
4	pH Optimum
1	pH Range
2	Posttranslational Modification
6	Protein Variants
4	Purification (Commentary)
2	Reaction
1	Reaction Type
16	Reference
23	Source Tissue
37	Substrates and Products (Substrate)
5	Subunits
42	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
4	Turnover Number [1/s]

Expression

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Expression on EC 4.2.1.93 - ATP-dependent NAD(P)H-hydrate dehydratase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

construction of cells deficient in the NAD(P)HX repair enzymes using HAP1 haploid cell lines and genetical modification by the CRISPR/Cas9 technology to disrupt the human homologue of the Saccharomyces cerevisiae YKL151C gene, NAXD. In the NAXD KO cell line, the mutated NAXD gene encodes a truncated protein containing the first 126 amino acids (out of the 329 amino acids of the native mitochondrial isoform) followed by nine non-native amino acids. Phenotype, detailed overview

Homo sapiens

Q8IW45

747751